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1.发明申请公开(公告)号：US20180208997A1
公开(公告)日：2018-07-26
申请号：US15926861
申请日：2018-03-20
申请人： Battelle Memorial Institute , Institute for Systems Biology , The Ohio State University Research Foundation
发明人： David Galas , Richard Evan Gelinas , Clay Braden Marsh , Melissa Garnet Piper , Kai Wang , Shile Zhang
IPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6883
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , C12Q2600/178
摘要： Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
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2.发明申请METHODS, COMPOSITIONS, AND DEVICES UTILIZING MicroRNA TO DETERMINE PHYSIOLOGICAL CONDITIONS 审中-公开利用微小RNA测定生理条件的方法，组合物和装置公开(公告)号：US20140287413A1
公开(公告)日：2014-09-25
申请号：US14300071
申请日：2014-06-09
申请人： Battelle Memorial Institute , Institute for Systems Biology , The Ohio State University Research Foundation
发明人： David Galas , Richard Evan Gelinas , Clay Braden Marsh , Melissa Garnet Piper , Kai Wang , Shile Zhang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , C12Q2600/178
摘要： Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
摘要翻译： 公开了使用微小RNA来检测，预测，治疗和监测诸如疾病或损伤的生理条件的方法，组合物和装置。 分离microRNA并测量其差异表达以提供诊断信息。 然后可以将该信息用于评估和/或治疗目的。
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公开(公告)号：US09856532B2
公开(公告)日：2018-01-02
申请号：US13830326
申请日：2013-03-14
发明人： Leroy Hood , Kai Wang , Inyoul Lee , Yong Zhou , Ji Hoon Cho , Dhimankrishna Ghosh
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder.
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公开(公告)号：US11964944B2
公开(公告)日：2024-04-23
申请号：US17831049
申请日：2022-06-02
申请人： The University of Chicago , University of Leeds , The J. Craig Venter Institute , Institute For Systems Biology , U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) , The University of Strathclyde
发明人： Rima McLeod , Martin McPhillie , Colin W. G. Fishwick , Hernan Alejandro Lorenzi , Kai Wang , Taek-Kyun Kim , Yong Zhou , Leroy E. Hood , Ying Zhou , Kamal El Bissati , Mark Hickman , QiGui Li , Craig Roberts
IPC分类号： C07D215/233 , A61P33/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
CPC分类号： C07D215/233 , A61P33/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
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公开(公告)号：US11414385B2
公开(公告)日：2022-08-16
申请号：US16063877
申请日：2016-12-20
申请人： The University of Chicago , University of Leeds , The J. Craig Venter Institute , Institute For Systems Biology , U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) , The University of Strathclyde
发明人： Rima McLeod , Martin McPhillie , Colin W. G. Fishwick , Hernan Alejandro Lorenzi , Kai Wang , Taek-Kyun Kim , Yong Zhou , Leroy E. Hood , Ying Zhou , Kamal El Bissati , Mark Hickman , QiGui Li , Craig Roberts
IPC分类号： C07D215/233 , A61P33/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
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公开(公告)号：US20210388443A1
公开(公告)日：2021-12-16
申请号：US17290931
申请日：2019-11-04
IPC分类号： C12Q1/6883
摘要： Methods for diagnosing and/or predicting presence of sepsis in a subject using a gene signature of three or more genes are provided. Also provided are sets containing specific binding molecules for each of the three or more genes, and kits containing such sets.
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公开(公告)号：US20140073516A1
公开(公告)日：2014-03-13
申请号：US13830326
申请日：2013-03-14
发明人： Leroy HOOD , Kai Wang , Inyoul Lee , Yong Zhou , Ji Hoon Cho , Dhimankrishna Ghosh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder.
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公开(公告)号：US20230140413A1
公开(公告)日：2023-05-04
申请号：US17831049
申请日：2022-06-02
申请人： The University of Chicago , University of Leeds , The J. Craig Venter Institute , Institute For Systems Biology , U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) , The University of Strathclyde
发明人： Rima McLeod , Martin McPhillie , Colin W.G. Fishwick , Hernan Alejandro Lorenzi , Kai Wang , Taek-Kyun Kim , Yong Zhou , Leroy E. Hood , Ying Zhou , Kamal El Bissati , Mark Hickman , QiGui Li , Craig Roberts
IPC分类号： C07D215/233 , A61P33/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
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