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公开(公告)号：US20230065629A1
公开(公告)日：2023-03-02
申请号：US17519329
申请日：2021-11-04
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230027985A1
公开(公告)日：2023-01-26
申请号：US17776961
申请日：2020-11-12
发明人： Daniel MEIBOM , Yolanda CANCHO GRANDE , Pierre WASNAIRE , Sarah Anna Liesa JOHANNES , Niels LINDNER , Kristin BEYER , Till FREUDENBERGER , Damian BROCKSCHNIEDER , Ilka MATHAR , Jürgen KLAR , Dmitry ZUBOV , Dzianis MENSHYKAU , Tanja KRAINZ , Eric STEFAN , Bryan MACDONALD , Yi XING , Nadine ELOWE , Guzman SANCHEZ
IPC分类号： C07D403/14 , C07D409/14 , C07D417/14 , C07D401/14 , C07D403/12 , A61K45/06
摘要： The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.
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3.发明申请公开(公告)号：US20220017540A1
公开(公告)日：2022-01-20
申请号：US17305927
申请日：2021-07-16
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Klemens LUSTIG , Karl COLLINS , Niels LINDNER , Janine NICOLAI , Moritz BECK-BROICHSITTER , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D519/00 , A61P11/00
摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
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公开(公告)号：US20230115270A1
公开(公告)日：2023-04-13
申请号：US17774459
申请日：2020-11-05
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Lisa DIETZ , Magdalena PLATZK , Daniel MEIBOM , Philipp BUCHGRABER , Niels LINDNER , Eva Maria BECKER-PELSTER , Carsten SCHMECK
IPC分类号： C07D417/12 , C07D413/12 , C07D277/28
摘要： The present application relates to novel substituted heterocyclic carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of breathing difficulties including sleep-induced breathing difficulties such as central and obstructive sleep apnoea, snoring (primary and obstructive snoring), dysphagia, peripheral and cardiac vascular disorders including diabetic microangiopathies and disorders of the peripheral and central nervous system including neurodegenerative and neuroinflammatory disorders.
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公开(公告)号：US20210024545A1
公开(公告)日：2021-01-28
申请号：US16319106
申请日：2017-07-10
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Klemens LUSTIG , Johanna ANLAHR , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN , Karl COLLINS , Niels LINDNER , Janine NICOLAI , Moritz BECK-BROICHSITTER
IPC分类号： C07D519/00 , A61K45/06 , A61K9/00 , A61K31/439 , A61K31/444 , A61K31/5386 , A61K31/55 , A61P11/00 , G16C20/64 , A61K31/5377 , A61K9/08
摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1-and/or TASK-3-blocking properties.
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![SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF](/abs-image/US/2019/05/30/US20190160048A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190160048A1
公开(公告)日：2019-05-30
申请号：US16300480
申请日：2017-05-08
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Kersten Matthias GERICKE , Florian KÖLLING , Klemens LUSTIG , Jörg MEDING , Heinrich MEIER , Thomas NEUBAUER , Martina SCHÄFER , Andreas TIMMERMANN , Dmitry ZUBOV , Carsten TERJUNG , Niels LINDNER , Volker BADOCK , Dieter MOOSMAYER , Hideki MIYATAKE ONDOZABAL , Steven MOORE , Alexander SCHULZ
IPC分类号： A61K31/437 , A61P29/00 , A61P11/00 , C07D471/04 , A61K31/506
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US20220324865A1
公开(公告)日：2022-10-13
申请号：US17055190
申请日：2019-05-10
发明人： Steffen MUELLER , Rudolf SCHOHE-LOOP , Nuria ORTEGA HERNANDEZ , Frank SUESSMEIER , Eloisa JIMENEZ NUNEZ , Thomas BRUMBY , Niels LINDNER , Christoph GERDES , Elisabeth POOK , Anja BUCHMUELLER , Fabienne Zdenka GAUGAZ , Dieter LANG , Stefanie ZIMMERMANN , Alexander Helmut Michael EHRMANN , Michael GERISCH , Lutz LEHMANN , Andreas TIMMERMANN , Martina SCHAEFER , Georg SCHMIDT , Karl-Heinz SCHLEMMER , Markus FOLLMANN , Elisabeth KERSTEN , Vivian WANG , Xiang GAO , Yafeng WANG
IPC分类号： C07D487/04 , A61P7/02
摘要： The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
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公开(公告)号：US20200316045A1
公开(公告)日：2020-10-08
申请号：US16756623
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Hanna TINEL , Niels LINDNER , Heiko SCHIRMER
IPC分类号： A61K31/4439 , A61K45/06 , C07D401/14 , A61K31/496 , C07D403/14 , C07D417/14 , A61K31/541 , A61K31/5377 , C07D413/14 , C07D409/14 , A61K31/4188 , C07D487/10 , A61K31/4196 , C07D403/06 , C07D405/14 , A61K31/551
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200055842A1
公开(公告)日：2020-02-20
申请号：US16341410
申请日：2017-10-09
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D487/04 , C07D405/14 , C07D413/14
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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