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公开(公告)号：US20170020875A1
公开(公告)日：2017-01-26
申请号：US15288982
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/506 , A61K45/06 , C07D405/14 , C07D413/04 , A61K31/538 , C07D401/04 , A61K31/536 , C07D409/14 , C07D417/14 , C07D403/04 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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![2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS](/abs-image/US/2019/02/28/US20190062326A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190062326A1
公开(公告)日：2019-02-28
申请号：US15756867
申请日：2016-12-07
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Heinrich MEIER , Klemens LUSTIG , Johanna MOSIG , Luisella TOSCHI , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , A61P11/16
摘要： The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.
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![SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF](/abs-image/US/2019/05/30/US20190160048A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190160048A1
公开(公告)日：2019-05-30
申请号：US16300480
申请日：2017-05-08
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Kersten Matthias GERICKE , Florian KÖLLING , Klemens LUSTIG , Jörg MEDING , Heinrich MEIER , Thomas NEUBAUER , Martina SCHÄFER , Andreas TIMMERMANN , Dmitry ZUBOV , Carsten TERJUNG , Niels LINDNER , Volker BADOCK , Dieter MOOSMAYER , Hideki MIYATAKE ONDOZABAL , Steven MOORE , Alexander SCHULZ
IPC分类号： A61K31/437 , A61P29/00 , A61P11/00 , C07D471/04 , A61K31/506
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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![SUBSTITUTED PERHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND THE USE OF SAME](/abs-image/US/2018/12/27/US20180370965A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180370965A1
公开(公告)日：2018-12-27
申请号：US15781848
申请日：2016-12-02
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Heinrich MEIER , Klemens LUSTIG , Johanna MOSIG , Luisella TOSCHI , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61P11/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61P11/00 , C07D519/00
摘要： The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.
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公开(公告)号：US20170020876A1
公开(公告)日：2017-01-26
申请号：US15288968
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , A61K31/538
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
摘要翻译： 本申请涉及新颖的双环取代的尿嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防 疾病
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公开(公告)号：US20200061063A1
公开(公告)日：2020-02-27
申请号：US16373487
申请日：2019-04-02
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/506 , A61K31/536
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20180256576A1
公开(公告)日：2018-09-13
申请号：US15912185
申请日：2018-03-05
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D403/04 , C07D417/14 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D471/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20170267648A1
公开(公告)日：2017-09-21
申请号：US15611467
申请日：2017-06-01
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Dmitry ZUBOV , Jens SCHAMBERGER
IPC分类号： C07D239/557 , C07D403/04 , C07D403/10 , C07D239/54 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , A61K31/513 , A61K9/20 , A61K9/08 , A61K9/00 , C07D417/14 , C07D403/14 , A61K45/06 , C07D403/12 , C07D413/14
CPC分类号： C07D239/557 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present application relates to novel substituted uracil derivatives, to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.
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公开(公告)号：US20160297771A1
公开(公告)日：2016-10-13
申请号：US15034499
申请日：2014-11-05
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER
IPC分类号： C07D239/557 , C07D413/14 , C07D417/10 , C07D409/06 , C07D403/10 , C07D413/10
CPC分类号： C07D239/557 , A61K31/513 , C07D403/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/10
摘要： The present application relates to novel substituted uracil derivatives of formula (I), to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.
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10.发明申请SUBSTITUTED 1,2,4-TRIAZINE-3,5-DIONES AND THE USE THEREOF AS CHYMASE INHIBITORS 审中-公开取代的1,2,4-三唑-3,5-二酮及其作为CHYMASE抑制剂的用途公开(公告)号：US20160287599A1
公开(公告)日：2016-10-06
申请号：US15035171
申请日：2014-11-05
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Dmitry ZUBOV , Jens SCHAMBERGER
IPC分类号： A61K31/53 , C07D413/10 , C07D413/04 , C07D403/10 , C07D403/04 , C07D417/04 , A61K45/06 , C07D253/075
CPC分类号： A61K31/53 , A61K45/06 , C07D253/075 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/04 , C07D413/10 , C07D417/04
摘要： Substituted 1,2,4-triazine-3,5-dione derivatives, processes for their preparation, their use alone or in combinations for the treatment and/or prophylaxis of diseases, and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
摘要翻译： 取代的1,2,4-三嗪-3,5-二酮衍生物，其制备方法，它们单独使用或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防的药物的用途 的疾病
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