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1.发明申请公开(公告)号：US20220017540A1
公开(公告)日：2022-01-20
申请号：US17305927
申请日：2021-07-16
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Klemens LUSTIG , Karl COLLINS , Niels LINDNER , Janine NICOLAI , Moritz BECK-BROICHSITTER , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D519/00 , A61P11/00
摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
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2.发明申请公开(公告)号：US20200093737A1
公开(公告)日：2020-03-26
申请号：US16472116
申请日：2017-12-13
发明人： Johanna ANLAHR , Moritz BECK-BROICHSITTER , Janine NICOLAI , Martina DELBECK , Michael HAHN , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： A61K9/00 , A61K47/10 , A61K31/496
摘要： The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.
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![2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS](/abs-image/US/2019/02/28/US20190062326A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190062326A1
公开(公告)日：2019-02-28
申请号：US15756867
申请日：2016-12-07
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Heinrich MEIER , Klemens LUSTIG , Johanna MOSIG , Luisella TOSCHI , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , A61P11/16
摘要： The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.
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公开(公告)号：US20220259228A1
公开(公告)日：2022-08-18
申请号：US17447795
申请日：2021-09-15
发明人： Martina DELBECK , Michael Hahn , Thomas Müller , Klemens Lustig , Johanna Anlahr , Udo Albus , Doris Gehring , Björn Rosenstein , Karl Collins , Niels Lindner , Janine Nicolai , Moritz Beck-Broichsitter
IPC分类号： C07D519/00 , A61P11/00 , G16C20/64 , A61K9/00 , A61K9/08 , A61K31/439 , A61K31/444 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K45/06
摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.
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公开(公告)号：US20210024545A1
公开(公告)日：2021-01-28
申请号：US16319106
申请日：2017-07-10
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Klemens LUSTIG , Johanna ANLAHR , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN , Karl COLLINS , Niels LINDNER , Janine NICOLAI , Moritz BECK-BROICHSITTER
IPC分类号： C07D519/00 , A61K45/06 , A61K9/00 , A61K31/439 , A61K31/444 , A61K31/5386 , A61K31/55 , A61P11/00 , G16C20/64 , A61K31/5377 , A61K9/08
摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1-and/or TASK-3-blocking properties.
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![SUBSTITUTED PERHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND THE USE OF SAME](/abs-image/US/2018/12/27/US20180370965A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180370965A1
公开(公告)日：2018-12-27
申请号：US15781848
申请日：2016-12-02
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Heinrich MEIER , Klemens LUSTIG , Johanna MOSIG , Luisella TOSCHI , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61P11/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61P11/00 , C07D519/00
摘要： The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.
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7.发明申请公开(公告)号：US20200085734A1
公开(公告)日：2020-03-19
申请号：US16471263
申请日：2017-12-13
发明人： Johanna ANLAHR , Moritz BECK-BROICHSITTER , Janine NICOLAI , Martina DELBECK , Michael HAHN , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： A61K9/00 , A61K47/10 , A61K31/496 , A61K47/26
摘要： The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
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公开(公告)号：US20200016159A1
公开(公告)日：2020-01-16
申请号：US16335282
申请日：2017-09-18
发明人： Michael HAERTER , Dirk KOSEMUND , Yolanda CANCHO GRANDE , Martina DELBECK , Bernd KALTHOF , Klemens LUSTIG , Frank SUESSMEIER
IPC分类号： A61K31/519 , A61K9/20 , A61K9/00 , A61K9/08 , C07D495/04
摘要： The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives having cyclic substituents in the 3 position, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.
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9.发明申请公开(公告)号：US20190002409A1
公开(公告)日：2019-01-03
申请号：US16125645
申请日：2018-09-07
发明人： Hartmut BECK , Tobias THALER , Raimund KAST , Daniel MEIBOM , Mark MEININGHAUS , Carsten TERJUNG , Martina DELBECK , Klemens LUSTIG , Uwe MUENSTER , Britta OLENIK
IPC分类号： C07D215/52 , C07D401/04 , C07D215/60 , C07D401/12
CPC分类号： C07D215/52 , C07D215/60 , C07D401/04 , C07D401/12
摘要： The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and/or inflammatory disorders.
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公开(公告)号：US20160244461A1
公开(公告)日：2016-08-25
申请号：US15027519
申请日：2014-10-02
发明人： Michael HÄRTER , Martina DELBECK , Bernd KALTHOF , Klemens LUSTIG , Niels LINDNER , Raimund KAST , Pierre WASNAIRE , Frank SÜßMEIER
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00 , A61K45/06
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.
摘要翻译： 本申请涉及新的2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-甲酰胺衍生物（“噻吩尿嘧啶” - 羧酰胺），其制备方法， 单独使用或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是用于治疗和/或预防肺和心血管疾病的药物的用途。
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