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    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS
    1.
    发明申请
    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS 审中-公开
    微生物菌株的应用及其使用方法来控制植物病虫害

    公开(公告)号：US20140105862A1

    公开(公告)日：2014-04-17

    申请号：US14052094

    申请日：2013-10-11

    Applicant: Bayer CropScience LP

    Inventor： Brian CAMPBELL ,  Damian CURTIS ,  Shaohua GUAN ,  Magalie GUILHABERT-GOYA ,  Daniel M. JOO ,  Tara LU ,  Jonathan S. MARGOLIS ,  Reed Nathan ROYALTY ,  Gerardo Bueno SALAZAR ,  David SESIN ,  Frisby Davis SMITH ,  Colleen TAYLOR ,  Hong ZHU

    IPC: A01N63/02 ,  A01N43/54

    CPC classification number: A01N63/02 ,  A01N43/54 ,  C12P19/28 ,  C12P19/385

    Abstract: The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus.

    Abstract translation: 本发明涉及新霉菌Streptomyces microflavus及其用于控制​​植物疾病或害虫的方法。 本发明还涉及通过培养产生Gougerotin的链霉菌菌株而获得的发酵液，其中发酵液含有至少约1g / L gougerotin。 本发明还涉及一种生产发酵木瓜霉菌菌株发酵液的方法，其中发酵液含有至少约1g / L gougerotin，该方法包括在含有可消化碳源的培养基中培养链霉菌属菌株， 在需氧条件下的可消化氮源，其中培养基含有浓度达到至少1g / L的gougerotin浓度的氨基酸。 本公开还涉及从Streptomyces microflavus分子克隆gougerotin生物合成基因簇，以及鉴定基因簇中的各个基因以及由此编码的蛋白质。 包含13个开放阅读框（ORF）的gougerotin基因簇位于Streptomyces microflavus的遗传基因座内。

    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS
    2.
    发明申请
    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS 审中-公开
    微生物菌株的应用及其使用方法来控制植物病虫害

    公开(公告)号：US20150299754A1

    公开(公告)日：2015-10-22

    申请号：US14688806

    申请日：2015-04-16

    Applicant: Bayer CropScience LP

    Inventor： Damian CURTIS ,  Shaohua GUAN ,  Magalie GUILHABERT-GOYA ,  Jonathan S. MARGOLIS ,  Reed Nathan ROYALTY ,  Frisby Davis SMITH ,  Colleen TAYLOR ,  Hong ZHU

    IPC: C12P19/40 ,  A01N43/54

    CPC classification number: C12P19/40 ,  A01N43/54 ,  A01N63/02

    Abstract: The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 2 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 2 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions.

    Abstract translation: 本发明涉及新霉菌Streptomyces microflavus及其用于控制​​植物疾病或害虫的方法。 本发明还涉及通过培养产生Gougerotin的链霉菌属菌株获得的发酵液，其中发酵液含有至少约2g / L gougerotin。 本发明还涉及一种生产发酵链霉菌菌株发酵液的方法，其中发酵液含有至少约2g / L gougerotin，该方法包括在含有可消化碳源的培养基中培养链霉菌属菌株， 在有氧条件下可消化氮源。

    METHOD OF INCREASING ABIOTIC STRESS RESISTANCE OF A PLANT
    4.
    发明申请
    METHOD OF INCREASING ABIOTIC STRESS RESISTANCE OF A PLANT 审中-公开
    增加植物抗生素耐力的方法

    公开(公告)号：US20140066302A1

    公开(公告)日：2014-03-06

    申请号：US14015464

    申请日：2013-08-30

    Applicant: Bayer CropScience LP

    Inventor： Magalie GUILHABERT-GOYA ,  Hong ZHU

    IPC: C05F11/08 ,  C09K17/00 ,  C05G3/00

    CPC classification number: C05F11/00 ,  A01N63/00 ,  C05F11/08 ,  C05G3/00 ,  C09K17/00

    Abstract: The invention relates to a method of increasing abiotic stress resistance enhancing soil nutrition of a plant, the method comprising applying a composition comprising Bacillus subtilis or Bacillus pumilus or a mutant thereof, to the plant, to a part of the plant and/or to an area around the plant or plant part. The invention also is directed to a method of enhancing soil nutrition comprising applying a composition comprising Bacillus subtilis or a mutant thereof to the soil.

    Abstract translation: 本发明涉及增加非植物胁迫抗性，增强植物土壤营养的方法，该方法包括将包含枯草芽孢杆菌或短小芽孢杆菌或其突变体的组合物施用于植物的一部分和/或 植物或植物部分周围的区域。 本发明还涉及一种增强土壤营养的方法，包括将包含枯草芽孢杆菌或其突变体的组合物施用于土壤中。

    COMPOSITIONS COMPRISING A STREPTOMYCES-BASED BIOLOGICAL CONTROL AGENT AND ANOTHER BIOLOGICAL CONTROL AGENT
    6.
    发明申请
    COMPOSITIONS COMPRISING A STREPTOMYCES-BASED BIOLOGICAL CONTROL AGENT AND ANOTHER BIOLOGICAL CONTROL AGENT 审中-公开
    包含基于分子生物学的生物控制剂和其他生物控制剂的组合物

    公开(公告)号：US20140302986A1

    公开(公告)日：2014-10-09

    申请号：US14176466

    申请日：2014-02-10

    Applicant: BAYER CROPSCIENCE LP

    Inventor： Wolfram ANDERSCH ,  Damian CURTIS ,  Shaohua GUAN ,  Magalie GUILHABERT-GOYA ,  Reed Nathan ROYALTY ,  Frisby Davis SMITH ,  Bernd SPRINGER ,  Wolfgang THIELERT ,  Hong ZHU

    IPC: A01N63/02 ,  A01N63/00

    CPC classification number: A01N43/54 ,  A01N63/00 ,  A01N63/02 ,  A01N63/04 ,  C12R1/07 ,  C12R1/125 ,  C12R1/465 ,  Y02A50/356

    Abstract: The present invention relates to a composition comprising a) Streptomyces microflavus strain NRRL B-50550 and/or a mutant thereof having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and/or a mutant thereof having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and b) at least one further biological control agent selected from specific microorganisms and/or a mutant of it having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

    Abstract translation: 本发明涉及一种组合物，其包含a）具有所述各菌株的所有鉴定特征的微生物链霉菌微链菌菌株NRRL B-50550和/或其突变体，和/或由相应菌株产生的至少一种对昆虫具有活性的代谢物 具有所有鉴定特征的各种菌株的螨虫，线虫和/或植物病原体和/或其突变体，和/或由相应菌株产生的至少一种代表物，其对昆虫，螨虫，线虫和/或植物病原体具有活性， b）至少一种选自特定微生物和/或具有各种菌株的所有鉴定特征的特异性微生物和/或其突变体的至少一种生物防治剂，和/或由各种菌株产生的至少一种代表物，其对昆虫，螨虫，线虫具有活性 和/或协同有效量的植物病原体。 此外，本发明涉及该组合物的用途以及减少植物和植物部分总体损伤的方法。

    NOVEL STRAINS OF STREPTOMYCES MICROFLAVUS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS
    7.
    发明申请
    NOVEL STRAINS OF STREPTOMYCES MICROFLAVUS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS 审中-公开
    新型微生物菌株及其用于控制​​植物病虫害的方法

    公开(公告)号：US20140107061A1

    公开(公告)日：2014-04-17

    申请号：US14052247

    申请日：2013-10-11

    Applicant: Bayer CropScience LP

    Inventor： Damian CURTIS ,  Shaohua GUAN ,  Magalie GUILHABERT-GOYA ,  Jonathan S. MARGOLIS ,  Reed Nathan ROYALTY ,  Gerardo Bueno SALAZAR ,  David SESIN ,  Frisby Davis SMITH ,  Colleen TAYLOR ,  Hong ZHU

    IPC: A01N43/54 ,  C12P19/38

    CPC classification number: A01N43/54 ,  C12N1/20 ,  C12N15/01 ,  C12P19/385 ,  C12R1/465

    Abstract: The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L.

    Abstract translation: 本发明涉及新霉菌Streptomyces microflavus及其用于控制​​植物疾病或害虫的方法。 本发明还涉及通过培养产生Gougerotin的链霉菌菌株而获得的发酵液，其中发酵液含有至少约1g / L gougerotin。 本发明还涉及一种生产发酵木瓜霉菌菌株发酵液的方法，其中发酵液含有至少约1g / L gougerotin，该方法包括在含有可消化碳源的培养基中培养链霉菌属菌株， 在需氧条件下的可消化氮源，其中培养基含有浓度达到至少1g / L的gougerotin浓度的氨基酸。

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