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公开(公告)号：US10772893B2
公开(公告)日：2020-09-15
申请号：US15974536
申请日：2018-05-08
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： C07D471/04 , C07D413/14 , A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10894784B2
公开(公告)日：2021-01-19
申请号：US16063370
申请日：2016-12-15
发明人： Volker Schulze , Tobias Heinrich , Florian Prinz , Julien Lefranc , Jens Schröder , Anne Mengel , Wilhelm Bone , Joszef Bálint , Antje Margret Wengner , Knut Eis , Horst Irlbacher , Marcus Koppitz , Ulf Bömer , Benjamin Bader , Hans Briem , Philip Lienau , Clara Christ , Detlef Stöckigt , Roman Hillig
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61P35/00
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US09549932B2
公开(公告)日：2017-01-24
申请号：US15159548
申请日：2016-05-19
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Franz Von Nussbaum , Benjamin Bader , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Dieter Moosmayer , Uwe Eberspächer , Hans Schick , Knut Eis , Marcus Koppitz , Antje Margret Wengner , Joanna Grudzinska-Goebel
IPC分类号： A61K31/5377 , A61K31/675 , A61K31/541 , A61K31/5386 , A61K45/06 , C07D471/04 , C07D491/22 , C07F9/6561 , C07D519/00 , A61K31/55
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的用途 疾病作为唯一的代理或与其他活性成分组合。
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公开(公告)号：US11524944B2
公开(公告)日：2022-12-13
申请号：US16765780
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D239/28 , A61P35/04 , C07D405/12 , A61K45/06
摘要： The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11304946B2
公开(公告)日：2022-04-19
申请号：US16765778
申请日：2018-11-16
发明人： Julien Lefranc , Norbert Schmees , Ulrike Röhn , Ludwig Zorn , Judith Günther , Ilona Gutcher , Lars Röse , Benjamin Bader , Detlef Stöckigt , Michael Platten
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , A61K31/506
摘要： The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R1, R2 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11529356B2
公开(公告)日：2022-12-20
申请号：US16999832
申请日：2020-08-21
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Marcus Koppitz , Knut Eis , Franz Von Nussbaum , Benjamin Bader , Antje Margret Wengner , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Joanna Grudzinska-Goebel , Dieter Moosmayer , Uwe Eberspächer , Hans Schick
IPC分类号： A61K31/4375 , A61K31/5377 , A61K31/4155 , C07D471/04 , C07D519/00 , C07D413/14 , A61P35/00 , A61P35/02 , A61K31/541 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D491/22 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10729680B2
公开(公告)日：2020-08-04
申请号：US16067830
申请日：2017-01-06
发明人： Ulrich Lücking , Marcus Koppitz , Julien Lefranc , Lars Wortmann , Antje Margret Wengner , Gerhard Siemeister , Ulf Bömer , Benjamin Bader , Philip Lienau , Hans Schick
IPC分类号： A61K31/4375 , A61P35/00 , A61K45/06 , C07D471/04
摘要： The present invention relates to 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20160287604A1
公开(公告)日：2016-10-06
申请号：US15159548
申请日：2016-05-19
发明人： Lars Wortmann , Ulrich Lücking , Julien Lefranc , Hans Briem , Franz Von Nussbaum , Benjamin Bader , Gerhard Siemeister , Wilhelm Bone , Philip Lienau , Dieter Moosmayer , Uwe Eberspächer , Hans Schick , Knut Eis , Marcus Koppitz , Antje Margret Wengner , Joanna Grudzinska-Goebel
IPC分类号： A61K31/5377 , C07D471/04 , C07F9/6561 , A61K31/55 , A61K31/541 , C07D519/00 , A61K31/5386 , C07D491/22 , A61K45/06 , A61K31/675
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的用途 疾病作为唯一的代理或与其他活性成分组合。
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