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公开(公告)号:US20220257547A1
公开(公告)日:2022-08-18
申请号:US17732761
申请日:2022-04-29
发明人: Anke Stroyer , Carmen Lobback , Peter Serno , Philipp Rubenbauer , Kai Lovis , Heiko Schirmer , Danja Grossbach , Donald Bierer , Britta Olenik , Tia Jacobs , Julia Küsel
摘要: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
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公开(公告)号:US20210113504A1
公开(公告)日:2021-04-22
申请号:US17132765
申请日:2020-12-23
发明人: Anke Stroyer , Carmen Lobback , Peter Serno , Philipp Rubenbauer , Kai Lovis , Heiko Schirmer , Danja Grossbach , Donald Bierer , Britta Olenik , Tia Jacobs , Julia Küsel
摘要: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
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公开(公告)号:US11298367B2
公开(公告)日:2022-04-12
申请号:US16758742
申请日:2018-10-17
发明人: Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Hana Cernecka , Karoline Droebner , Hanna Tinel , Anja Buchmueller , Thomas Mondritzki , Axel Kretschmer , Klemens Lustig , Robert Fricke , Guillaume Levilain , Ursula Krenz , Norbert Witowski
IPC分类号: A61K31/675 , A61P13/12 , A61K45/06 , C07F9/6558
摘要: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号:US11173151B2
公开(公告)日:2021-11-16
申请号:US16756623
申请日:2018-10-17
发明人: Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Hanna Tinel , Niels Lindner , Heiko Schirmer
IPC分类号: A61K31/4439 , A61K31/4188 , A61K31/4196 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/10
摘要: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号:US20200030270A1
公开(公告)日:2020-01-30
申请号:US16043567
申请日:2018-07-24
发明人: Anke Stroyer , Carmen Lobback , Peter Serno , Philipp Rubenbauer , Kai Lovis , Heiko Schirmer , Danja Grossbach , Donald Bierer , Britta Olenik , Tia Jacobs , Julia Kusel
摘要: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
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公开(公告)号:US11344519B2
公开(公告)日:2022-05-31
申请号:US17132765
申请日:2020-12-23
发明人: Anke Stroyer , Carmen Lobback , Peter Serno , Philipp Rubenbauer , Kai Lovis , Heiko Schirmer , Danja Grossbach , Donald Bierer , Britta Olenik , Tia Jacobs , Julia Küsel
IPC分类号: A61K31/00 , A61K9/00 , A61K31/192 , A61K9/20 , A61K47/10 , A61K47/38 , A61K45/06 , A61P25/28 , A61P13/00 , A61P9/10
摘要: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
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公开(公告)号:US10526314B2
公开(公告)日:2020-01-07
申请号:US16098202
申请日:2017-05-02
发明人: Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Hanna Tinel , Heiko Schirmer
IPC分类号: C07D401/14 , C07D403/14 , C07D417/14 , A61P9/10 , A61P9/12 , A61P13/12 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06
摘要: The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号:US10905667B2
公开(公告)日:2021-02-02
申请号:US16043567
申请日:2018-07-24
发明人: Anke Stroyer , Carmen Lobback , Peter Serno , Philipp Rubenbauer , Kai Lovis , Heiko Schirmer , Danja Grossbach , Donald Bierer , Britta Olenik , Tia Jacobs , Julia Küsel
IPC分类号: A61K31/00 , A61K9/00 , A61K47/00 , A61P9/10 , A61P25/28 , A61K31/192 , A61K9/20 , A61K47/10 , A61K47/38 , A61K45/06 , A61P13/00
摘要: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
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公开(公告)号:US11331314B2
公开(公告)日:2022-05-17
申请号:US16758802
申请日:2018-10-17
发明人: Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Hanna Tinel , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Klemens Lustig
IPC分类号: A61K31/496 , A61P9/12 , A61K31/4196 , A61K31/422 , A61K31/454 , A61K31/541 , A61K31/55 , A61K45/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/10
摘要: The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号:US11091463B2
公开(公告)日:2021-08-17
申请号:US16579341
申请日:2019-09-23
发明人: Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmueller , Hanna Tinel , Karoline Droebner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号: A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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