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公开(公告)号：US11298367B2
公开(公告)日：2022-04-12
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Hana Cernecka , Karoline Droebner , Hanna Tinel , Anja Buchmueller , Thomas Mondritzki , Axel Kretschmer , Klemens Lustig , Robert Fricke , Guillaume Levilain , Ursula Krenz , Norbert Witowski
IPC分类号： A61K31/675 , A61P13/12 , A61K45/06 , C07F9/6558
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10927109B2
公开(公告)日：2021-02-23
申请号：US16333079
申请日：2017-09-06
发明人： Henrik Teller , Alexandros Vakalopoulos , Melissa Boultadakis Arapinis , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximilian Andreas Kullmann , Till Freudenberger , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/06 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US11472803B2
公开(公告)日：2022-10-18
申请号：US17161201
申请日：2021-01-28
发明人： Henrik Teller , Alexandros Vakalopoulos , Melissa Boultadakis Arapinis , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximillian Andreas Kullmann , Till Freudenberger , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US10519154B2
公开(公告)日：2019-12-31
申请号：US16317322
申请日：2017-07-04
发明人： Henrik Teller , Melissa Boultadakis Arapinis , Alexandros Vakalopoulos , Anne-Sophie Rebstock , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximillian Andreas Kullmann , Klaus Münter , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61P9/06 , A61P13/12 , A61P9/04
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US09988367B2
公开(公告)日：2018-06-05
申请号：US15581064
申请日：2017-04-28
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06
CPC分类号： C07D401/14 , A61K31/4439 , A61K45/06
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10472348B2
公开(公告)日：2019-11-12
申请号：US15969222
申请日：2018-05-02
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10435403B2
公开(公告)日：2019-10-08
申请号：US15735138
申请日：2016-06-06
发明人： Henrik Teller , Alexander Straub , Markus Brechmann , Thomas Müller , Mark Meininghaus , Katrin Nowak-Reppel , Hanna Tinel , Klaus Münter , Daniela Fliegner , Thomas Mondritzki , Melissa Boultadakis Arapinis , Tobias Marquardt , Alexandros Vakalopoulos , Anne-Sophie Rebstock , Matthias Beat Wittwer
IPC分类号： C07D471/04 , A61P9/04 , A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US09771352B2
公开(公告)日：2017-09-26
申请号：US14930157
申请日：2015-11-02
发明人： Carsten Schmeck , Michael Gerisch , Nils Griebenow , Peter Kolkhof , Florian Kölling , Anna Engelen , Axel Kretschmer , Dieter Lang , Klemens Lustig , Thomas Mondritzki , Elisabeth Pook , Hartmut Beck , Frank Süβmeier , Sonja Vollmer , Pierre Wasnaire
IPC分类号： C07D403/06 , A61K31/4196 , A61K45/06
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
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公开(公告)号：US11091463B2
公开(公告)日：2021-08-17
申请号：US16579341
申请日：2019-09-23
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmueller , Hanna Tinel , Karoline Droebner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10815205B2
公开(公告)日：2020-10-27
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： C07D249/14 , C07D403/06 , A61P9/00 , A61P13/12 , A61K31/4196 , A61K45/06 , C07D249/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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