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公开(公告)号：US11472803B2
公开(公告)日：2022-10-18
申请号：US17161201
申请日：2021-01-28
发明人： Henrik Teller , Alexandros Vakalopoulos , Melissa Boultadakis Arapinis , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximillian Andreas Kullmann , Till Freudenberger , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US10927109B2
公开(公告)日：2021-02-23
申请号：US16333079
申请日：2017-09-06
发明人： Henrik Teller , Alexandros Vakalopoulos , Melissa Boultadakis Arapinis , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximilian Andreas Kullmann , Till Freudenberger , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/06 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US10519154B2
公开(公告)日：2019-12-31
申请号：US16317322
申请日：2017-07-04
发明人： Henrik Teller , Melissa Boultadakis Arapinis , Alexandros Vakalopoulos , Anne-Sophie Rebstock , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximillian Andreas Kullmann , Klaus Münter , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61P9/06 , A61P13/12 , A61P9/04
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US10435403B2
公开(公告)日：2019-10-08
申请号：US15735138
申请日：2016-06-06
发明人： Henrik Teller , Alexander Straub , Markus Brechmann , Thomas Müller , Mark Meininghaus , Katrin Nowak-Reppel , Hanna Tinel , Klaus Münter , Daniela Fliegner , Thomas Mondritzki , Melissa Boultadakis Arapinis , Tobias Marquardt , Alexandros Vakalopoulos , Anne-Sophie Rebstock , Matthias Beat Wittwer
IPC分类号： C07D471/04 , A61P9/04 , A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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![N-substituted 8-[(2,6-difluorobenzyl)oxy]-2,6- dimethylimidazo[1,2-a]pyrazin-3-carboxamide derivatives as stimulators of soluble guanylate cyclase (SGC) for the treatment of cardiovascular diseases](/abs-image/US/2018/12/11/US10150773B2/abs.jpg.150x150.jpg)
公开(公告)号：US10150773B2
公开(公告)日：2018-12-11
申请号：US15548310
申请日：2016-02-02
发明人： Alexandros Vakalopoulos , Damian Brockschnieder , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Lisa Dietz , Min Jian Volkhart Li
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07B59/00 , C07F7/08
摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides of general formula (I) to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![Substituted pyrazolo[1,5-a]-pyridine-3-carboxamides and use thereof](/abs-image/US/2019/02/26/US10214526B2/abs.jpg.150x150.jpg)
公开(公告)号：US10214526B2
公开(公告)日：2019-02-26
申请号：US15548158
申请日：2016-02-02
发明人： Alexandros Vakalopoulos , Damian Brockschnieder , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Lisa Dietz , Min Jian Volkhart Li
IPC分类号： C07D471/04
摘要： The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US09714266B2
公开(公告)日：2017-07-25
申请号：US14770444
申请日：2014-02-18
发明人： Ulrich Bothe , Matthias Busemann , Naomi Barak , Andrea Rotgeri , Oliver Martin Fischer , Tobias Marquardt
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
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![3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines](/abs-image/US/2017/06/27/US09688699B2/abs.jpg.150x150.jpg)
公开(公告)号：US09688699B2
公开(公告)日：2017-06-27
申请号：US15116366
申请日：2015-02-17
发明人： Alexandros Vakalopoulos , Alexey Gromov , Markus Follmann , Damian Brockschnieder , Johannes-Peter Stasch , Tobias Marquardt , Adrian Tersteegen , Frank Wunder , Gorden Redlich , Dieter Lang , Volkhart Min-Jian Li
IPC分类号： C07D519/00 , A61K45/06 , A61K31/53 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
摘要： The present application relates to novel 3-(pyrimidin-2-yl)imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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![Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof](/abs-image/US/2017/03/28/US09605008B2/abs.jpg.150x150.jpg)
公开(公告)号：US09605008B2
公开(公告)日：2017-03-28
申请号：US14903347
申请日：2014-07-08
发明人： Alexandros Vakalopoulos , Alexey Gromov , Markus Follmann , Damian Brockschnieder , Johannes-Peter Stasch , Tobias Marquardt , Adrian Tersteegen , Frank Wunder , Gorden Redlich , Dieter Lang , Volkhart Min-Jian Li
IPC分类号： A61K31/53 , C07D519/00 , C07D519/04 , A61K45/06
CPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , C07D519/04
摘要： The present application relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![Cyano-substituted imidazo[1,2-A]pyridinecarboxamides and their use](/abs-image/US/2017/09/26/US09771360B2/abs.jpg.150x150.jpg)
公开(公告)号：US09771360B2
公开(公告)日：2017-09-26
申请号：US15120377
申请日：2015-03-18
发明人： Alexandros Vakalopoulos , Philipp Buchgraber , Niels Lindner , Markus Follmann , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Gorden Redlich , Lisa Dietz , Volkhart Min-Jian Li
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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