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1.发明授权公开(公告)号：US10385316B2
公开(公告)日：2019-08-20
申请号：US15246241
申请日：2016-08-24
IPC分类号： C12N5/00 , A61K38/00 , A61K39/00 , C12N5/02 , C12N5/0783 , A61K39/12 , A61K39/155 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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公开(公告)号：US20180187152A1
公开(公告)日：2018-07-05
申请号：US15905176
申请日：2018-02-26
IPC分类号： C12N5/0783 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： C12N5/0638 , A61K39/12 , A61K2039/5158 , A61K2039/55527 , A61K2039/57 , A61K2039/572 , A61K2039/577 , A61K2039/70 , C12N7/00 , C12N2501/2302 , C12N2501/2304 , C12N2501/2307 , C12N2501/2315 , C12N2710/16134 , C12N2710/16234 , Y02A50/394 , Y02A50/467
摘要： The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
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3.发明申请公开(公告)号：US20220282218A1
公开(公告)日：2022-09-08
申请号：US17804239
申请日：2022-05-26
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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公开(公告)号：US20210348127A1
公开(公告)日：2021-11-11
申请号：US17443261
申请日：2021-07-23
IPC分类号： C12N5/0783 , A61K39/12 , C12N7/00
摘要： The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
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5.发明申请公开(公告)号：US20190264176A1
公开(公告)日：2019-08-29
申请号：US16408093
申请日：2019-05-09
IPC分类号： C12N5/0783 , A61K39/155 , A61K39/00 , A61K39/12 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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6.发明申请GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES 审中-公开具有针对多种肿瘤抗原或多种病毒的特异性的CTL系的产生公开(公告)号：US20160362658A1
公开(公告)日：2016-12-15
申请号：US15246241
申请日：2016-08-24
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/155 , A61K39/245 , A61K39/12
CPC分类号： C12N5/0638 , A61K39/0011 , A61K39/12 , A61K39/155 , A61K39/245 , A61K2039/5158 , A61K2039/54 , A61K2039/572 , C12N5/0636 , C12N2501/23 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2502/11
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
摘要翻译： 本发明包括用于产生和使用靶向多种病毒或对多种肿瘤抗原特异的细胞毒性T淋巴细胞的方法和组合物。 在具体实施方案中，生成方法使用某些细胞因子来促进活化的T细胞群体中的增殖和减少细胞死亡，和/或使用具有透气膜的特定生物反应器。
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公开(公告)号：US20150010519A1
公开(公告)日：2015-01-08
申请号：US14377825
申请日：2013-02-08
IPC分类号： C12N5/0783 , C12N7/00 , A61K39/12
CPC分类号： C12N5/0638 , A61K39/12 , A61K2039/5158 , A61K2039/55527 , A61K2039/57 , A61K2039/572 , A61K2039/577 , A61K2039/70 , C12N7/00 , C12N2501/2302 , C12N2501/2304 , C12N2501/2307 , C12N2501/2315 , C12N2710/16134 , C12N2710/16234 , Y02A50/394 , Y02A50/467
摘要： The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
摘要翻译： 本发明涉及产生能够靶向来自两种或多种病毒的至少一种抗原的CTL的方法。 该方法包括将针对不同抗原的肽的混合物暴露于相同的多个PBMC，并且至少在某些方面，在IL4和IL7存在下扩增细胞。
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公开(公告)号：US11981923B2
公开(公告)日：2024-05-14
申请号：US17659624
申请日：2022-04-18
IPC分类号： C12N5/0783 , A61K39/12 , C07K14/025 , C07K14/03 , C07K14/11 , C07K14/135 , C12N7/00 , A61K39/00
CPC分类号： C12N5/0638 , A61K39/12 , C07K14/025 , C07K14/03 , C07K14/11 , C07K14/135 , C12N7/00 , A61K2039/5158 , A61K2039/55527 , A61K2039/57 , A61K2039/572 , A61K2039/577 , A61K2039/70 , C12N2501/2302 , C12N2501/2304 , C12N2501/2307 , C12N2501/2315 , C12N2710/16134 , C12N2710/16234 , Y02A50/30
摘要： The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.
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9.发明公开公开(公告)号：US20230357721A1
公开(公告)日：2023-11-09
申请号：US18354308
申请日：2023-07-18
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/245
CPC分类号： C12N5/0638 , C12N5/0636 , A61K39/0011 , A61K39/12 , A61K39/155 , A61K39/245 , C12N2501/23 , A61K2039/5158 , A61K2039/54 , A61K2039/572 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2502/11
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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10.发明申请公开(公告)号：US20230114971A1
公开(公告)日：2023-04-13
申请号：US18062452
申请日：2022-12-06
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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