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公开(公告)号：US11103868B2
公开(公告)日：2021-08-31
申请号：US16338042
申请日：2018-10-11
发明人： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Yingying Zhao , Haochen Cui , Nan Zhao , Yuelei Xiao , Hui Liao , Chuncheng Che
IPC分类号： B01L3/00
摘要： The present disclosure provides a microfluidic chip, a biological detection device and a method. The microfluidic chip includes: a first substrate and a second substrate that are oppositely disposed; a first electrode and a second electrode that are oppositely disposed between the first substrate and the second substrate, the first electrode including a plurality of spaced first electrode units, and the second electrode including a plurality of spaced second electrode units, wherein the first electrode units are disposed oppositely to the second electrode units in one-to-one correspondence; a first dielectric layer and a second dielectric layer between the first electrode and the second electrode; a first hydrophobic layer and a second hydrophobic layer between the first dielectric layer and the second dielectric layer, wherein a gap is between the first hydrophobic layer and the second hydrophobic layer.
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公开(公告)号：US11684916B2
公开(公告)日：2023-06-27
申请号：US16632934
申请日：2019-01-09
发明人： Wenliang Yao , Nan Zhao , Haochen Cui , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Chuncheng Che
CPC分类号： B01L3/502715 , C12Q1/686 , B01L2300/0645 , B01L2300/1827
摘要： A chip for polymerase chain reaction, a method of operating a chip for polymerase chain reaction, and a reaction device are provided. The chip includes: a sample adding region, a mixing region, a temperature cycling region in a sequential arrangement, and at least one driving unit group. The at least one driving unit group includes a plurality of driving units and is configured to drive a liquid drop to move and sequentially pass through the sample adding region, the mixing region, and the temperature cycling region.
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公开(公告)号：US20210331162A1
公开(公告)日：2021-10-28
申请号：US16626490
申请日：2019-07-26
发明人： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
摘要： A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US11865538B2
公开(公告)日：2024-01-09
申请号：US16757902
申请日：2019-03-27
发明人： Wenliang Yao , Nan Zhao , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Bolin Fan
IPC分类号： B01L3/00 , G01N33/487 , H01L27/12
CPC分类号： B01L3/502715 , G01N33/48707 , H01L27/1214 , B01L2300/0645 , B01L2300/0819
摘要： A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
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公开(公告)号：US11691147B2
公开(公告)日：2023-07-04
申请号：US16641126
申请日：2019-07-26
发明人： Mingyang Lv , Yue Li , Yanchen Li , Jinyu Li , Dawei Feng , Yu Zhao , Dong Wang , Wang Guo , Hailong Wang , Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu , Chuncheng Che , Haochen Cui , Yingying Zhao , Nan Zhao , Yuelei Xiao , Hui Liao
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502792 , B01L2200/10 , B01L2300/0645 , B01L2300/165 , B01L2400/0427
摘要： A digital microfluidic chip and a digital microfluidic system. The digital microfluidic chip comprises: an upper substrate and a lower substrate arranged opposite to each other; multiple driving circuits and multiple addressing circuits disposed between the lower substrate and the upper substrate; and a control circuit, electrically connected to the driving circuits and the addressing circuits. The control circuit is configured to apply, in a driving stage, a driving voltage to each driving circuit, such that a droplet is controlled to move inside a droplet accommodation space according to a set path, measure, in a detection stage, after a bias voltage is applied to each addressing circuit, a charge loss amount of each addressing circuit, and to determine the position of the droplet according to the charge loss amount. The charge loss amount of each addressing circuit is related to the intensity of received external light.
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公开(公告)号：US11498068B2
公开(公告)日：2022-11-15
申请号：US16632931
申请日：2019-01-02
发明人： Wenliang Yao , Haochen Cui , Peizhi Cai , Yuelei Xiao , Fengchun Pang , Yue Geng , Le Gu , Nan Zhao , Hui Liao , Yingying Zhao , Chuncheng Che
IPC分类号： B01L3/00
摘要： A microfluidic device, a microfluidic detection assembly and a detection method for the microfluidic device. The microfluidic device includes a first substrate and a second substrate; the first substrate and the second substrate are oppositely arranged to define a channel between the first substrate and the second substrate, the channel is configured for liquid to flow, the first substrate includes a base substrate and a plurality of control assemblies which are arranged on the base substrate along an extending direction of the channel, each of the plurality of control assemblies includes: a first electrode, a second electrode and a plurality of coils, and the first electrode is configured to input currents into the plurality of coils, and the plurality of coils are connected in parallel to the second electrode.
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公开(公告)号：US11383238B2
公开(公告)日：2022-07-12
申请号：US16626490
申请日：2019-07-26
发明人： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
摘要： A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US11344891B2
公开(公告)日：2022-05-31
申请号：US16768558
申请日：2019-11-13
发明人： Yingying Zhao , Peizhi Cai , Le Gu , Fengchun Pang , Yue Geng , Yuelei Xiao , Haochen Cui , Nan Zhao , Hui Liao , Wenliang Yao , Chuncheng Che
IPC分类号： B01L3/00
摘要： The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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公开(公告)号：US11344889B2
公开(公告)日：2022-05-31
申请号：US16603648
申请日：2019-04-26
发明人： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
摘要： The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US20210322973A1
公开(公告)日：2021-10-21
申请号：US16603648
申请日：2019-04-26
发明人： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
摘要： The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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