公开(公告)号：US10752885B2

公开(公告)日：2020-08-25

申请号：US15865540

申请日：2018-01-09

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  Xiamen University

发明人： Hua Zhu ,  Yimin Li ,  Ningshao Xia ,  Tong Cheng ,  Xiangzhong Ye

IPC分类号： C12N7/00 ,  A61K39/25 ,  C07K14/005 ,  A61K39/12 ,  C12N15/86 ,  A61K39/00

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

公开(公告)号：US11220673B2

公开(公告)日：2022-01-11

申请号：US16847360

申请日：2020-04-13

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Rutgers, the State University of New Jersey ,  Xiamen University

发明人： Hua Zhu ,  Yimin Li ,  Ningshao Xia ,  Tong Cheng ,  Xiangzhong Ye

IPC分类号： C12N7/00 ,  A61K39/25 ,  C07K14/005 ,  A61K39/12 ,  C12N15/86 ,  A61K39/00

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

公开(公告)号：US11793844B2

公开(公告)日：2023-10-24

申请号：US16632741

申请日：2018-07-18

申请人： XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

发明人： Tong Cheng ,  Wei Wang ,  Junkai Wan ,  Wenkun Fu ,  Xiangzhong Ye ,  Jun Zhang ,  Ningshao Xia

IPC分类号： A61K35/768 ,  A61P35/00 ,  C12N7/00 ,  C12N15/86 ,  A61K48/00 ,  C07K14/535 ,  C07K16/28 ,  C12N15/113

CPC分类号： A61K35/768 ,  A61P35/00 ,  C12N7/00 ,  C12N15/86 ,  A61K48/00 ,  C07K14/535 ,  C07K16/2818 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/141 ,  C12N2770/32321 ,  C12N2770/32332 ,  C12N2770/32343 ,  C12N2770/32371

摘要： Provided are an enterovirus D68 (EV-D68) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the EV-D68 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, or a pharmaceutical composition comprising the EV-D68 or a modified form thereof, or the nucleic acid molecule, and use of the EV-D68 or a modified form thereof, or the nucleic acid molecule in the manufacture of a pharmaceutical composition for treating a tumor.

公开(公告)号：US11707496B2

公开(公告)日：2023-07-25

申请号：US16641117

申请日：2018-08-15

申请人： XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

发明人： Tong Cheng ,  Wei Wang ,  Junkai Wan ,  Longfa Xu ,  Xiangzhong Ye ,  Jun Zhang ,  Ningshao Xia

IPC分类号： A61K35/768 ,  A61P35/00 ,  A61K31/711 ,  A61K48/00 ,  A61K35/66 ,  C07K14/00 ,  C12N15/86 ,  C07K14/005 ,  C12N15/79 ,  A61K45/00 ,  C12N15/63 ,  C12N15/09 ,  A61K38/00 ,  A61K35/00 ,  A61K38/16 ,  A61K45/06

CPC分类号： A61K35/768 ,  A61K31/711 ,  A61K35/00 ,  A61K35/66 ,  A61K38/00 ,  A61K38/16 ,  A61K45/00 ,  A61K48/00 ,  A61K48/0008 ,  A61P35/00 ,  C07K14/00 ,  C07K14/005 ,  C12N15/09 ,  C12N15/63 ,  C12N15/79 ,  C12N15/86 ,  A61K45/06

摘要： Provided are use of an Echovirus 25 (ECHO25) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the ECHO25 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, in treatment of a tumor in a subject, and in the manufacture of a medicament for treatment a tumor in a subject.