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    Certain thiazole-5-carboxamide compounds
    1.
    发明授权
    Certain thiazole-5-carboxamide compounds 失效
    某些噻唑-5-甲酰胺化合物

    公开(公告)号：US4064135A

    公开(公告)日：1977-12-20

    申请号：US706412

    申请日：1976-07-19

    申请人： Belig M. Berkoz ,  Brian Lewis ,  Joseph M. Muchowski

    发明人： Belig M. Berkoz ,  Brian Lewis ,  Joseph M. Muchowski

    IPC分类号： C07D277/36 ,  C07D277/56

    CPC分类号： C07D277/56 ,  C07D277/36

    摘要： Processes and intermediates for preparing 1-alkylamino-3-(5-substitutedaminocarbonylthiazol-2-yloxy)-2-propanols and 5-(5-substitutedaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine and 2-substituted oxazolidine derivatives thereof and intermediates therefore. The present processes, and intermediates, reduce the number of transformations necessary to produce these products as compared with the prior processes. The products are useful to treat abnormal heart conditions and/or hypertension in mammals. The intermediates are 2-alkylsulfinyl-5-substitutedaminocarbonylthiazoles and 2-alkylsulfonyl-5-substitutedaminocarbonylthiazoles.

    摘要翻译： 因此，制备1-烷基氨基-3-（5-取代氨基羰基噻唑-2-基氧基）-2-丙醇和5-（5-取代氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷及其2-取代的恶唑烷衍生物及其中间体的方法和中间体 。 本方法和中间体与以前的方法相比，减少了生产这些产品所需的转化次数。 该产品可用于治疗哺乳动物的异常心脏病和/或高血压。 中间体是2-烷基亚磺酰基-5-取代的氨基羰基噻唑和2-烷基磺酰基-5-取代的氨基羰基噻唑。

    Thiazole cardiovascular agents
    2.
    发明授权
    Thiazole cardiovascular agents 失效
    噻唑心血管药

    公开(公告)号：US4064259A

    公开(公告)日：1977-12-20

    申请号：US706413

    申请日：1976-07-19

    申请人： Belig M. Berkoz ,  Brian Lewis ,  Stefan H. Unger

    发明人： Belig M. Berkoz ,  Brian Lewis ,  Stefan H. Unger

    IPC分类号： C07D277/56 ,  A61K31/425

    CPC分类号： C07D277/56

    摘要： 1-Alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanol; 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidines and derivatives are also intermediates for the 1-alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanols. The 1-alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative; or by treatment of the corresponding 3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine. Similarly the 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative can be prepared from the corresponding 1-alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanols via treatment with an aldehyde or ketone.

    摘要翻译： 1-烷基氨基-3-（5-链烯基氨基羰基噻唑-2-基氧基）-2-丙醇; 5-（5-链烯基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷和/或其2-取代的恶唑烷衍生物及其制备方法。 该化合物显示出心血管活性，并且可用于治疗哺乳动物的异常心脏病。 该化合物也可用于治疗哺乳动物的高血压。 5-（5-链烯基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷及其衍生物也是1-烷基氨基-3-（5-链烯基氨基羰基噻唑-2-基氧基）-2-丙醇的中间体。 1-烷基氨基-3-（5-链烯基氨基羰基噻唑-2-基氧基）-2-丙醇可以通过相应的5-（5-链烯基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷或其衍生物的碱或酸水解来制备。 或通过用所需的烷基胺处理相应的3-（5-链烯基氨基羰基噻唑-2-基氧基）-2,3-环氧丙烷。 类似地，5-（5-链烯基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷或衍生物可以由相应的1-烷基氨基-3-（5-链烯基氨基羰基噻唑-2-基氧基）-2-丙醇通过用醛或 酮。

    Thiazole cardiovascular agents
    3.
    发明授权
    Thiazole cardiovascular agents 失效
    噻唑心血管药

    公开(公告)号：US4064257A

    公开(公告)日：1977-12-20

    申请号：US706341

    申请日：1976-07-19

    申请人： Belig M. Berkoz ,  Brian Lewis ,  Stefan H. Unger

    发明人： Belig M. Berkoz ,  Brian Lewis ,  Stefan H. Unger

    IPC分类号： C07D277/36 ,  C07D277/56 ,  A61K31/425

    CPC分类号： C07D277/36 ,  C07D277/56

    摘要： 1-Alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanol; 5-(5-alkynylaminocarbonyl-thiazol-2-yloxymethylene)-N-alkyloxazolidine and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-alkynyl-aminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidines and derivatives are also intermediates for the 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols. The 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-alkynylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative; or by treatment of the corresponding 3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine. Similarly the 5-(5-alkynylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative can be prepared from the corresponding 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols via treatment with an aldehyde or ketone.

    摘要翻译： 1-烷基氨基-3-（5-炔基氨基羰基噻唑-2-基氧基）-2-丙醇; 5-（5-炔基氨基羰基 - 噻唑-2-基氧基亚甲基）-N-烷基恶唑烷和/或其2-取代的恶唑烷衍生物及其制备方法。 该化合物显示出心血管活性，并且可用于治疗哺乳动物的异常心脏病。 该化合物也可用于治疗哺乳动物的高血压。 5-（5-炔基 - 氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷及其衍生物也是1-烷基氨基-3-（5-炔基氨基羰基噻唑-2-基氧基）-2-丙醇的中间体。 1-烷基氨基-3-（5-炔基氨基羰基噻唑-2-基氧基）-2-丙醇可以通过相应的5-（5-炔基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷或其衍生物的碱或酸水解制备。 或通过用所需的烷基胺处理相应的3-（5-炔基氨基羰基噻唑-2-基氧基）-2,3-环氧丙烷。 类似地，5-（5-炔基氨基羰基噻唑-2-基氧基亚甲基）-N-烷基恶唑烷或衍生物可以由相应的1-烷基氨基-3-（5-炔基氨基羰基噻唑-2-基氧基）-2-丙醇通过用醛或 酮。

    Toilet Paper Holster Charging Station
    5.
    发明申请
    Toilet Paper Holster Charging Station 审中-公开

    公开(公告)号：US20200138249A1

    公开(公告)日：2020-05-07

    申请号：US16374908

    申请日：2019-04-04

    申请人： Brian Lewis

    发明人： Brian Lewis

    IPC分类号： A47K10/22

    摘要： A toilet paper holster charging station. The toilet paper holster charging station includes a housing having a top portion with opposing arms extending from a bottom thereof. A support shaft spans between the opposing arms and is rotatably attached thereto. The support shaft is removably affixed to the opposing arms and can hold a roll of toilet paper thereon. An electrical outlet is disposed in an arm of the housing and includes standard sockets as well as Universal Serial Bus (USB) outlets for plugging in and charging devices. The electrical outlet is configured to be connected to the electrical grid of a house through wired connection running through the walls. A shelving portion is included on the top surface of the housing to allow a user to rest an electrical device thereon while charging.

    Pressure balancing water heater dip tube turbulator attachment
    7.
    发明授权
    Pressure balancing water heater dip tube turbulator attachment 失效
    压力平衡热水器汲取管湍流器附件

    公开(公告)号：US4898150A

    公开(公告)日：1990-02-06

    申请号：US321876

    申请日：1989-03-10

    申请人： Brian Lewis

    发明人： Brian Lewis

    IPC分类号： F24H9/12

    CPC分类号： F24H9/124

    摘要： The present invention relates to an end piece for a water heater dip tube which converts the dip tube from primarily a water feed only, to a combination water feed and turbulator. The end piece comprises an end face at right angles to the water flow through the dip tube with openings radially around the end face and the openings being symmetrically positioned for balanced pressure water flow to all sides of the end piece thereby eliminating directional torque on the dip tube itself.

    摘要翻译： 本发明涉及一种用于将浸渍管从主要仅从水进料转换成组合进水和湍流器的热水器浸管的端件。 端件包括与通过浸入管的水流成直角的端面，开口径向地围绕端面，并且开口对称地定位，用于平衡的压力水流到端部件的所有侧面，从而消除了倾斜的方向扭矩 管本身。

    Surface acoustic wave filters
    8.
    发明授权
    Surface acoustic wave filters 失效
    表面声波滤波器

    公开(公告)号：US4144508A

    公开(公告)日：1979-03-13

    申请号：US820625

    申请日：1977-07-28

    申请人： Brian Lewis ,  John M. Deacon

    发明人： Brian Lewis ,  John M. Deacon

    IPC分类号： H03H3/08 ,  H03H9/145 ,  H03H9/64 ,  H03H9/04 ,  H01L41/10 ,  H03H9/26 ,  H03H9/32

    CPC分类号： H03H9/1452 ,  H03H9/6489

    摘要： A surface acoustic wave filter for television or other video apparatus comprising a plurality of transducers, wherein at least one weighted transducer includes a pattern of interleaved metal fingers formed on a surface of a piezo-electric substrate, the filter including means for reducing spurious peak signals originating from within the transducer.

    摘要翻译： 一种用于电视或其他视频设备的表面声波滤波器，包括多个换能器，其中至少一个加权换能器包括形成在压电基板的表面上的交错金属指状图案，该滤波器包括用于减少杂散峰值信号 源自传感器内。