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1.
公开(公告)号:US20090156577A1
公开(公告)日:2009-06-18
申请号:US12268529
申请日:2008-11-11
申请人: Benjamin Davis , Eugene B. Grant, III , Shu-Chen Lin , Mark J. Macielag , Michele Ann Weidner-Wells , Xiaoqing Xu , Xiaodong Xu , Bin Zhu
发明人: Benjamin Davis , Eugene B. Grant, III , Shu-Chen Lin , Mark J. Macielag , Michele Ann Weidner-Wells , Xiaoqing Xu , Xiaodong Xu , Bin Zhu
IPC分类号: A61K31/5365 , C07D471/04 , A61K31/4375 , C07D401/04 , A61K31/4709 , C07D498/16
CPC分类号: C07D471/04 , C07D401/04 , C07D401/14 , C07D498/04 , C07D498/14 , C07D519/00
摘要: The present invention relates to compounds having a structure according to Formula (I) wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
摘要翻译: 本发明涉及具有式(I)结构的化合物,其中n,m,z,R,R 2,R 3,R 4,R 5,R 6,A,E,X,Y,a和b如上所定义; 或其光学异构体,非对映异构体或对映异构体; 其药学上可接受的盐,水合物或前药。
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公开(公告)号:US07179805B2
公开(公告)日:2007-02-20
申请号:US10937238
申请日:2004-09-09
申请人: Eugene B. Grant, III , Mark J. Macielag , Xiaoqing Xu , Steven David Paget , Michele Ann Weidner-Wells
发明人: Eugene B. Grant, III , Mark J. Macielag , Xiaoqing Xu , Steven David Paget , Michele Ann Weidner-Wells
IPC分类号: A61K31/4353 , A61K31/5383 , C07D215/14 , C07D471/14 , C07D498/04
CPC分类号: C07D403/04 , C07D401/04 , C07D471/04
摘要: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
摘要翻译: 本发明涉及具有式I结构的化合物,其中n,m,z,R,R 2,R 3,R 4, R 5,R 6,A,E,X,Y,a和b如上所定义; 或其光学异构体,非对映异构体或对映异构体; 其药学上可接受的盐,水合物或前药。
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公开(公告)号:US07732612B2
公开(公告)日:2010-06-08
申请号:US11084987
申请日:2005-03-21
申请人: Eugene B. Grant , Mark J. Macielag , Steven David Paget , Michele Ann Weidner-Wells , Xiaoqing Xu , Xiaodong Xu
发明人: Eugene B. Grant , Mark J. Macielag , Steven David Paget , Michele Ann Weidner-Wells , Xiaoqing Xu , Xiaodong Xu
IPC分类号: C07D215/38
CPC分类号: C07D215/56 , C07D401/04 , C07D471/04
摘要: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
摘要翻译: 本发明涉及具有式I结构的化合物,其中n,m,z,R,R 2,R 3,R 4,R 5,R 6,A,E,X,Y,a和b如上所定义; 或其光学异构体,非对映异构体或对映异构体; 其药学上可接受的盐,水合物或前药。
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公开(公告)号:US08450497B2
公开(公告)日:2013-05-28
申请号:US12797712
申请日:2010-06-10
申请人: Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人: Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号: C07D413/00
CPC分类号: A61K31/5383 , A61K31/4184 , C07D233/52 , C07D235/30 , C07D498/06
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
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公开(公告)号:US20110003801A1
公开(公告)日:2011-01-06
申请号:US12797743
申请日:2010-06-10
申请人: Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人: Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号: A61K31/5383 , C07D235/30 , C07D498/06 , A61K31/4184 , A61P9/12 , A61P9/00 , A61P25/04 , A61P29/00
CPC分类号: C07D235/30 , C07D498/06
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式I表示如下:其中R 0,R 1,R 2,R 3,R 4和a在本文中定义。
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公开(公告)号:US20110003800A1
公开(公告)日:2011-01-06
申请号:US12797712
申请日:2010-06-10
申请人: Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人: Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号: A61K31/5383 , C07D235/30 , C07D498/06 , A61K31/4184 , A61P9/12 , A61P9/00 , A61P25/04 , A61P29/00
CPC分类号: A61K31/5383 , A61K31/4184 , C07D233/52 , C07D235/30 , C07D498/06
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
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公开(公告)号:US08242157B2
公开(公告)日:2012-08-14
申请号:US12797743
申请日:2010-06-10
申请人: Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人: Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号: C07D401/00 , C07D235/12 , C07D235/22 , A01N43/52 , A61K31/415
CPC分类号: C07D235/30 , C07D498/06
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式I表示如下:其中R 0,R 1,R 2,R 3,R 4和a在本文中定义。
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公开(公告)号:US20060052359A1
公开(公告)日:2006-03-09
申请号:US11084987
申请日:2005-03-21
申请人: Eugene Grant , Mark Macielag , Steven Paget , Michele Weidner-Wells , Xiaoqing Xu , Xiaodong Xu
发明人: Eugene Grant , Mark Macielag , Steven Paget , Michele Weidner-Wells , Xiaoqing Xu , Xiaodong Xu
IPC分类号: A61K31/519 , A61K31/4745 , A61K31/4709 , C07D487/02 , C07D403/02
CPC分类号: C07D215/56 , C07D401/04 , C07D471/04
摘要: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
摘要翻译: 本发明涉及具有式I结构的化合物
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公开(公告)号:US08143259B2
公开(公告)日:2012-03-27
申请号:US12539267
申请日:2009-08-11
申请人: Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Donald W. Ludovici , Jay M. Matthews , Mingde Xia , Xiaoqing Xu , Mark A. Youngman , Bin Zhu
发明人: Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Donald W. Ludovici , Jay M. Matthews , Mingde Xia , Xiaoqing Xu , Mark A. Youngman , Bin Zhu
IPC分类号: A61K31/495 , A61K31/47 , A61K31/404 , A61K31/40 , C07D241/04 , C07D215/02 , C07D209/04 , C07D207/08
CPC分类号: C07D207/08 , C07D209/08 , C07D209/44 , C07D217/06 , C07D241/04 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/06 , C07D417/06
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
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公开(公告)号:US20140128428A1
公开(公告)日:2014-05-08
申请号:US14152006
申请日:2014-01-10
申请人: Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Donald W. Ludovici , Mingde Xia , Xiaoqing Xu , Mark A. Youngman , Bin Zhu
发明人: Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Donald W. Ludovici , Mingde Xia , Xiaoqing Xu , Mark A. Youngman , Bin Zhu
IPC分类号: C07D217/04
CPC分类号: C07D217/04 , C07C237/20 , C07C2102/08 , C07C2602/08 , C07D215/38 , C07D217/02 , C07D401/12
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式(I)表示如下:其中A,L,R 1,R 2,R 4和R 5在本文中定义。
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