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    Treatment of rumen acidosis with α-amylase inhibitors
    1.
    发明授权
    Treatment of rumen acidosis with α-amylase inhibitors 失效
    用α-淀粉酶抑制剂治疗瘤胃酸中毒

    公开(公告)号：US07271158B2

    公开(公告)日：2007-09-18

    申请号：US10774139

    申请日：2004-02-06

    申请人： Bernard Joseph Banks ,  Mark Andrew Haxell ,  Graham Lunn ,  Michael Stephen Pacey ,  Lee Richard Roberts

    发明人： Bernard Joseph Banks ,  Mark Andrew Haxell ,  Graham Lunn ,  Michael Stephen Pacey ,  Lee Richard Roberts

    IPC分类号： A01N43/04 ,  A61K31/715 ,  C07H1/00

    CPC分类号： A61K31/715 ,  A23K10/12 ,  A23K20/163 ,  A23K50/10 ,  A61K31/7016 ,  A61K31/702

    摘要： The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase to a ruminant; a formulation suitable for the treatment of acidosis in an animal which comprises an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial α-amylase and/or α-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial α-amylase and/or α-glucosidase; a compound of the formula I: or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial α-amylase and/or α-glucosidase useful for the treatment of acidosis in a ruminant.

    摘要翻译： 本文描述的发明涉及：在制备用于治疗酸中毒的组合物中使用细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂; 一种治疗瘤胃酸中毒的方法，包括向反刍动物施用有效量的有效的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂; 适用于治疗动物中的酸中毒的制剂，其包含与适当的赋形剂，稀释剂或载体混合的有效抑制细菌α-淀粉酶和/或α-葡萄糖苷酶的方法，所述适合的赋形剂，稀释剂或载体相对于预期给药途径和标准药物 /兽医/农业实践; 用于鉴定用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的合适抑制剂的筛选方法; 一种改善反刍动物奶质量和/或量的方法，其包括用有效量的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂处理反刍动物; 式I化合物或兽医学上可接受的盐，溶剂合物（包括水合物）或其前药; 并且制备用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂的方法。

    Treatment of rumen acidosis with α-amylase inhibitors
    2.
    发明授权
    Treatment of rumen acidosis with α-amylase inhibitors 失效
    用α-淀粉酶抑制剂治疗瘤胃酸中毒

    公开(公告)号：US07022684B2

    公开(公告)日：2006-04-04

    申请号：US10059667

    申请日：2002-01-29

    申请人： Bernard Joseph Banks ,  Mark Andrew Haxell ,  Graham Lunn ,  Michael Stephen Pacey ,  Lee Richard Roberts

    发明人： Bernard Joseph Banks ,  Mark Andrew Haxell ,  Graham Lunn ,  Michael Stephen Pacey ,  Lee Richard Roberts

    IPC分类号： A01N43/04 ,  A61K31/715

    CPC分类号： A61K31/715 ,  A23K10/12 ,  A23K20/163 ,  A23K50/10 ,  A61K31/7016 ,  A61K31/702

    摘要： The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase to a ruminant; a formulation suitable for the treatment of rumen acidosis in an animal which comprises an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial α-amylase and/or α-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial α-amylase and/or α-glucosidase; a compound of the formula I: or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial α-amylase and/or α-glucosidase useful for the treatment of acidosis in a ruminant.

    摘要翻译： 本文描述的发明涉及：在制备用于治疗瘤胃酸中毒的组合物中使用细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂; 一种治疗瘤胃酸中毒的方法，包括向反刍动物施用有效量的有效的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂; 适用于在动物中治疗瘤胃酸中毒的制剂，其包含与适当的赋形剂，稀释剂或载体混合的细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂，所述合适的赋形剂，稀释剂或载体根据预期给药途径和标准 制药/兽医/农业实践; 用于鉴定用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的合适抑制剂的筛选方法; 一种改善反刍动物奶质量和/或量的方法，其包括用有效量的细菌α-淀粉酶和/或α-葡糖苷酶抑制剂处理反刍动物; 式I化合物或兽医学上可接受的盐，溶剂合物（包括水合物）或其前药; 并且制备用于治疗反刍动物酸中毒的细菌α-淀粉酶和/或α-葡糖苷酶的有效抑制剂的方法。

    PROTECTIVE INSERT FOR AN ITEM OF HEADWEAR
    7.
    发明申请
    PROTECTIVE INSERT FOR AN ITEM OF HEADWEAR 审中-公开
    头盔保护插件

    公开(公告)号：US20140230133A1

    公开(公告)日：2014-08-21

    申请号：US14347589

    申请日：2012-10-09

    申请人： Lee Richard Roberts

    发明人： Lee Richard Roberts

    IPC分类号： A42B3/12

    CPC分类号： A42B3/12 ,  A42B1/08

    摘要： A protective insert for an item of golfing headwear with integral rigid peak. The protective insert is configured to protect a user's head from injury caused by a golf ball.

    摘要翻译： 高尔夫球头保护插件，具有整体刚性高度。 保护插入物被配置为保护使用者的头部不受高尔夫球引起的伤害。