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    Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses
    4.
    发明授权
    Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses 失效
    用于治疗牛皮癣和过敏反应的α-烷基聚烯烃羧酸及其衍生物

    公开(公告)号：US4694023A

    公开(公告)日：1987-09-15

    申请号：US710768

    申请日：1985-03-11

    申请人： Bernard Loev ,  Wan-kit Chan ,  Howard Jones

    发明人： Bernard Loev ,  Wan-kit Chan ,  Howard Jones

    IPC分类号： A61K31/16 ,  A61K31/20 ,  A61K31/23 ,  C07C403/00 ,  C07C57/03

    CPC分类号： A61K31/23 ,  A61K31/16 ,  A61K31/20 ,  C07C403/20 ,  C07C2101/16

    摘要： Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

    摘要翻译： 由通式“IMAGE”表示的聚烯烃化合物，其中R和R 1各自为氢或1至5个碳原子的烷基; R2是1至5个碳原子的烷基; R3是羟基，1至5个碳原子的烷氧基，NH2，NHR2或NR2R2，Z是被0-5个烷基取代的环烷基，环烯基或环二烯基，酮基或羟基或被 0至4个羟基，烷氧基，烷基或三氟甲基或卤素原子或其组合及其药学上可接受的盐。 已经发现前述化合物在治疗牛皮癣，炎性病症和过敏反应方面是有效的。

    Polyene compounds useful in the treatment of psoriasis and allergic responses
    5.
    发明授权
    Polyene compounds useful in the treatment of psoriasis and allergic responses 失效
    可用于治疗牛皮癣和过敏反应的多烯化合物

    公开(公告)号：US4534979A

    公开(公告)日：1985-08-13

    申请号：US667703

    申请日：1984-11-02

    申请人： Bernard Loev ,  Wan-Kit Chan ,  Howard Jones

    发明人： Bernard Loev ,  Wan-Kit Chan ,  Howard Jones

    IPC分类号： A61K31/16 ,  A61K31/20 ,  A61K31/23 ,  A61K31/18 ,  A61K31/19

    CPC分类号： C07C403/20 ,  A61K31/16 ,  A61K31/20 ,  A61K31/23 ,  C07C2101/16

    摘要： Polyene compounds represented by the general formulae ##STR1## in which: R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms;R.sub.2 is an alkyl group of from 1 to 5 carbon atoms;R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl, aryloxy, aralkyloxy or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

    摘要翻译： 由通式 表示的多烯化合物，其中：R 1和R 1各自为氢或1至5个碳原子的烷基; R2是1至5个碳原子的烷基; R3是羟基，1至5个碳原子的烷氧基，NH2，NHR2或NR2R2，Z是被0-5个烷基取代的环烷基，环烯基或环二烯基，酮基或羟基或被 0至4个羟基，烷氧基，烷基，芳氧基，芳烷氧基或三氟甲基或卤素原子或其组合及其药学上可接受的盐。 已经发现前述化合物在治疗牛皮癣，炎性病症和过敏反应方面是有效的。

    Polyene compounds useful in the treatment of allergic responses
    8.
    发明授权
    Polyene compounds useful in the treatment of allergic responses 失效
    可用于治疗过敏反应的多烯化合物

    公开(公告)号：US4605675A

    公开(公告)日：1986-08-12

    申请号：US787843

    申请日：1985-10-16

    申请人： Bernard Loev ,  Wan-Kit Chan

    发明人： Bernard Loev ,  Wan-Kit Chan

    IPC分类号： A61K31/05 ,  A61K31/075 ,  A61K31/085

    CPC分类号： C07C403/02 ,  C07C2101/16

    摘要： Polyene compounds represented by the formula ##STR1## in which R is H or an alkyl group of from 1 to 5 carbon atoms, R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl, and the pharmaceutically acceptable salts thereof.The foregoing compounds have been found active in regulating phospholipases and as such possess therapeutic value in the treatment of inflammatory conditions.

    摘要翻译： 其中R为H或1至5个碳原子的烷基，R 1为H，1至8个碳原子的低级烷基或芳烷基，其化学式为“IMAGE”的多烯化合物及其药学上可接受的盐。 已经发现前述化合物在调节磷脂酶中是有活性的，因此具有治疗炎性病症的治疗价值。

    Polyene compounds useful in the treatment of allergic responses
    9.
    发明授权
    Polyene compounds useful in the treatment of allergic responses 失效
    可用于治疗过敏反应的多烯化合物

    公开(公告)号：US4621099A

    公开(公告)日：1986-11-04

    申请号：US778952

    申请日：1985-09-23

    申请人： Bernard Loev ,  Wan-Kit Chan

    发明人： Bernard Loev ,  Wan-Kit Chan

    IPC分类号： A61K31/165 ,  A61K31/20 ,  A61K31/215 ,  A61K31/41 ,  A61K31/19

    CPC分类号： A61K31/165 ,  A61K31/20 ,  A61K31/215 ,  A61K31/41

    摘要： Polyene compounds represented by the formula ##STR1## in which R is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl;R.sub.1 is H or lower alkyl of from 1 to 5 carbon atoms; andY is carboxy, alkoxycarbonyl, alkenyloxycarbonyl, aralkoxycarbonyl, tetrazolyl or ##STR2## wherein R is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl; and pharmaceutically acceptable salts thereof.The foregoing compounds have been found active in regulating the formation of lipoxygenase and as such possess therapeutic value in the treatment of inflammatory conditions and allergic responses.

    摘要翻译： 式中，R为H，1〜8个碳原子的低级烷基或芳烷基; R1是H或1至5个碳原子的低级烷基; 并且Y是羧基，烷氧基羰基，烯氧基羰基，芳烷氧基羰基，四唑基或其中R是H，1至8个碳原子的低级烷基或芳烷基; 和其药学上可接受的盐。 已经发现前述化合物在调节脂氧合酶的形成中具有活性，因此具有治疗炎性病症和过敏反应的治疗价值。

    Polyene compounds useful in the treatment of allergic responses
    10.
    发明授权
    Polyene compounds useful in the treatment of allergic responses 失效
    可用于治疗过敏反应的多烯化合物

    公开(公告)号：US4619945A

    公开(公告)日：1986-10-28

    申请号：US785682

    申请日：1985-10-09

    申请人： Bernard Loev ,  Wan-Kit Chan

    发明人： Bernard Loev ,  Wan-Kit Chan

    IPC分类号： C07C43/23 ,  C07C45/00 ,  C07C45/41 ,  C07C47/277 ,  C07C59/52 ,  C07C59/68 ,  A61K31/045

    CPC分类号： C07C43/23 ,  C07C45/00 ,  C07C45/41 ,  C07C47/277 ,  C07C59/52 ,  C07C59/68

    摘要： Polyene compounds represented by the formula ##STR1## where R is H or lower alkyl of from 1 to 5 carbon atoms;R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl; andR.sub.2 is (CH.sub.2).sub.n CH.sub.2 OH, CHO or CO.sub.2 R; wherein n is 1 or 2.The foregoing compounds have been found active in regulating the formation of lipoxygenase and as such possess therapeutic value in the treatment of inflammatory conditions and allergic responses.

    摘要翻译： 由下式表示的多烯化合物，其中R是H或具有1至5个碳原子的低级烷基; R1是H，1至8个碳原子的低级烷基或芳烷基; R2为（CH2）nCH2OH，CHO或CO2R; 其中n为1或2.已发现前述化合物在调节脂氧合酶的形成中具有活性，因此具有治疗炎症和过敏反应的治疗价值。