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    Mitogen-activated protein kinase kinase MEK6 and methods of use thereof
    1.
    发明申请
    Mitogen-activated protein kinase kinase MEK6 and methods of use thereof 审中-公开
    丝裂原活化蛋白激酶激酶MEK6及其使用方法

    公开(公告)号：US20060110799A1

    公开(公告)日：2006-05-25

    申请号：US11327047

    申请日：2006-01-05

    申请人： Bernd Stein ,  Maria Yang

    发明人： Bernd Stein ,  Maria Yang

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N9/12

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

    摘要翻译： 提供组合物和方法来增强丝裂原活化蛋白激酶p38的活性。 特别地提供了刺激磷酸化p38的丝裂原活化蛋白激酶激酶MEK6及其变体​​。 这样的化合物可用于例如治疗与p38级联相关的疾病，并鉴定通过p38抑制或激活信号转导的抗体和其它试剂。

    Mitogen-activated protein kinase kinase MEK6 and methods of use therefor
    2.
    发明申请
    Mitogen-activated protein kinase kinase MEK6 and methods of use therefor 审中-公开
    丝裂原活化蛋白激酶激酶MEK6及其使用方法

    公开(公告)号：US20050255094A1

    公开(公告)日：2005-11-17

    申请号：US11004789

    申请日：2004-12-03

    申请人： Bernd Stein ,  Maria Yang

    发明人： Bernd Stein ,  Maria Yang

    IPC分类号： A61K38/00 ,  A61K38/48 ,  C07H21/04 ,  C12N9/12 ,  C12N15/54 ,  C12P21/06

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

    摘要翻译： 提供组合物和方法来增强丝裂原活化蛋白激酶p38的活性。 特别地提供了刺激磷酸化p38的丝裂原活化蛋白激酶激酶MEK6及其变体​​。 这样的化合物可用于例如治疗与p38级联相关的疾病，并鉴定通过p38抑制或激活信号转导的抗体和其它试剂。

    PROCESS FOR HYDROGENATING NITRILES
    4.
    发明申请
    PROCESS FOR HYDROGENATING NITRILES 审中-公开
    加氢处理方法

    公开(公告)号：US20120245389A1

    公开(公告)日：2012-09-27

    申请号：US13427308

    申请日：2012-03-22

    申请人： Christof Wilhelm Wigbers ,  Christoph Müller ,  Wolfgang Mägerlein ,  Martin Ernst ,  Thomas Heidemann ,  Johann-Peter Melder ,  Lucia Königsmann ,  Milind Joshi ,  Oliver Bey ,  Bernd Stein

    发明人： Christof Wilhelm Wigbers ,  Christoph Müller ,  Wolfgang Mägerlein ,  Martin Ernst ,  Thomas Heidemann ,  Johann-Peter Melder ,  Lucia Königsmann ,  Milind Joshi ,  Oliver Bey ,  Bernd Stein

    IPC分类号： C07C209/48

    CPC分类号： C07C209/48 ,  C07C2601/14 ,  C07C211/36 ,  C07C211/09

    摘要： The present invention relates to a process for hydrogenating organic nitriles by means of hydrogen in the presence of a catalyst in a reactor, where the shaped body catalyst is arranged in a fixed bed, wherein the shaped body in the shape of spheres or rods has in each case a diameter 3 mm or less, in the shape of tablets a height of 4 mm or less, and in the case of all other geometries in each case has an equivalent diameter L=1/a′ of 0.70 mm or less, where a′ is the external surface area per unit volume (mms2/mmp3), where: a ′ = A p V p , where Ap is the external surface area of the catalyst particle (mms2) and Vp is the volume of the catalyst particle (mmp3). The present invention further relates to a process for preparing downstream products of isophoronediamine (IPDA) or N,N-dimethylaminopropylamine (DMAPA) from amines prepared according to the invention.

    摘要翻译： 本发明涉及一种在反应器中催化剂存在下通过氢气氢化有机腈的方法，其中成形体催化剂布置在固定床中，其中球体或棒状的成形体具有 每个壳体的直径为3mm以下，片状形状为4mm以下，在各种情况下，所有其他几何形状的等效直径L = 1 / a'为0.70mm以下，其中 a'是每单位体积的外表面积（mms2 / mmp3），其中：a'= A p V p，其中Ap是催化剂颗粒的外表面积（mms2），Vp是催化剂颗粒的体积 mmp3）。 本发明还涉及由根据本发明制备的胺制备异佛尔酮二胺（IPDA）或N，N-二甲基氨基丙胺（DMAPA）的下游产物的方法。

    METHODS OF MANUFACTURING TOOTHBRUSHES
    6.
    发明申请
    METHODS OF MANUFACTURING TOOTHBRUSHES 审中-公开
    制造牙刷的方法

    公开(公告)号：US20090241279A1

    公开(公告)日：2009-10-01

    申请号：US12481251

    申请日：2009-06-09

    申请人： Bernd Stein ,  Mark McConnell ,  Joseph DePuydt ,  Michael Vankov ,  Ahmet Cem Firatli

    发明人： Bernd Stein ,  Mark McConnell ,  Joseph DePuydt ,  Michael Vankov ,  Ahmet Cem Firatli

    IPC分类号： A46B9/04 ,  A46B9/00

    CPC分类号： A46D3/005 ,  B29C45/14385

    摘要： A method is provided for manufacturing a function element carrier with function elements, for example, individual tufts made up of bristles and/or massage elements, interproximal cleaning elements, or other elements designed to be fastened to a toothbrush and also perform special functions. The function elements are equipped at their ends intended for anchoring in a toothbrush with an anchor, retainer or axle element. The method includes: (a) inserting several function elements in corresponding recesses of an injection mold, said injection mold being connected via grid or bar shaped channels formed in a die to recesses in the areas of the anchoring ends of the function elements; (b) filling the grid or bar shaped channels with liquefied plastic material and injecting said material at the anchoring ends of the function elements or embedding them therein; and (c) allowing the plastic material to cool and removing a function element carrier made up of a grid or bar shaped plastic frame and the function elements. Function element carriers and toothbrushes are also provided.

    摘要翻译： 提供了一种用于制造功能元件载体的方法，功能元件载体具有功能元件，例如由刷毛和/或按摩元件，邻间清洁元件或设计为固定到牙刷的其它元件构成的单个簇，并且还执行特殊功能。 功能元件在其端部装备，用于锚固在具有锚定器，保持器或轴元件的牙刷中。 该方法包括：（a）将多个功能元件插入到注射模具的相应凹槽中，所述注射模具通过形成在模具中的格栅或条形通道连接到功能元件的锚定端部区域中的凹部; （b）用液化塑料材料填充格子或条形通道，并在功能元件的锚定端注入所述材料或将其嵌入其中; 和（c）允许塑料材料冷却并去除由格栅或条形塑料框架和功能元件构成的功能元件载体。 还提供功能元件载体和牙刷。

    Work-up of the mother liquor obtained in the preparation of high-purity triethylenediamine
    8.
    发明授权
    Work-up of the mother liquor obtained in the preparation of high-purity triethylenediamine 有权
    在制备高纯三乙二胺时得到的母液的处理

    公开(公告)号：US07345173B2

    公开(公告)日：2008-03-18

    申请号：US10138337

    申请日：2002-05-06

    申请人： Ortmund Lang ,  Bernd Rumpf ,  Matthias Frauenkron ,  Dirk Funhoff ,  Thomas Manderbach ,  Bernd Stein

    发明人： Ortmund Lang ,  Bernd Rumpf ,  Matthias Frauenkron ,  Dirk Funhoff ,  Thomas Manderbach ,  Bernd Stein

    IPC分类号： C07D487/00

    CPC分类号： C07D487/08

    摘要： In a process for the purification of triethylenediamine (TEDA) in which TEDA is vaporized and the gaseous TEDA is passed into a liquid solvent and is subsequently crystallized from this, the mother liquor obtained after the TEDA has been crystallized is extracted with an extractant which is immiscible or only slightly miscible with the solvent of the mother liquor and in which TEDA is readily soluble, and the TEDA-depleted mother liquor obtained after extraction and/or the TEDA-enriched extractant which has been used for the extraction are/is returned to the process.

    摘要翻译： 在其中TEDA蒸发并将气态TEDA进入液体溶剂并随后从其中结晶的三亚乙基二胺（TEDA）的纯化方法中，在TEDA结晶后获得的母液用萃取剂萃取，萃取剂为 不混溶或仅与母液的溶剂轻微混溶，其中TEDA易溶，并且在萃取后获得的TEDA贫化母液和/或用于萃取的富含TEDA的萃取剂返回至 的过程。

    Method of selectively synthesizing triethylenediamine
    9.
    发明授权
    Method of selectively synthesizing triethylenediamine 失效
    选择性合成三亚乙基二胺的方法

    公开(公告)号：US06958397B2

    公开(公告)日：2005-10-25

    申请号：US10482644

    申请日：2002-07-04

    申请人： Matthias Frauenkron ,  Bernd Stein ,  Ortmund Lang

    发明人： Matthias Frauenkron ,  Bernd Stein ,  Ortmund Lang

    IPC分类号： B01J29/40 ,  C07B61/00 ,  C07D487/08

    CPC分类号： C07D487/08 ,  B01J29/40 ,  B01J2229/42

    摘要： The present invention describes a process for the preparation of triethylenediamine by reacting piperazine over a zeolite catalyst which, in addition to SiO2, contains an oxide of at least one further divalent, trivalent or tetravalent metal M, wherein the zeolite has a molar Si/M ratio of >100. In particular, a zeolite of the ZSM-5 type is used. The use of the zeolites permits suppression of the undesired formation of the byproduct 2-ethylpiperazine and hence considerable simplification of the working-up, in combination with high piperazine conversions and a small excess of water.

    摘要翻译： 本发明描述了一种通过哌嗪在沸石催化剂上反应制备三亚乙基二胺的方法，该沸石催化剂除SiO 2外还含有至少另外一种二价，三价或四价金属M的氧化物，其中 沸石的Si / M摩尔比> 100。 特别地，使用ZSM-5型的沸石。 沸石的使用允许抑制副产物2-乙基哌嗪的不期望的形成，因此相当简化的加工，加上高哌嗪转化率和少量过量的水。