公开(公告)号：US08774475B2

公开(公告)日：2014-07-08

申请号：US13257315

申请日：2010-02-19

申请人： Bernhard Brendel ,  Holger Eggers ,  Adri J. Duijndam

发明人： Bernhard Brendel ,  Holger Eggers ,  Adri J. Duijndam

IPC分类号： G06K9/00

CPC分类号： G01R33/4828 ,  G01R33/56563

摘要： When distinguishing between fat and water in acquired MR data, a modified Dixon technique includes acquiring first and second signals Ii and I2, calculating the first and second components B and S of the signals Iχ and I2, where one of the first and second components corresponds to fat and the other corresponds to water, deriving two differential phase error candidates from them, and selecting a phase error candidate based on the assumption of smoothness of the disturbing field inhomogeneity. The exact determination of the absolute values of the water and fat components is then made by solving three signal equations for two variables that respectively correspond to water and fat, and is performed using for example a least square minimization with a Newton method.

摘要翻译： 在获取的MR数据中区分脂肪和水时，修改的Dixon技术包括获取第一和第二信号Ii和I2，计算信号Iχ和I2的第一和第二分量B和S，其中第一和第二分量中的一个对应于 脂肪，另一个对应于水，从它们中导出两个差分相位误差候选，并且基于干扰场不均匀性的平滑度的假设来选择相位误差候选。 然后通过求解分别对应于水和脂肪的两个变量的三个信号方程，并且使用例如使用牛顿法的最小二乘法来进行水和脂肪成分的绝对值的确切确定。

公开(公告)号：US20120008847A1

公开(公告)日：2012-01-12

申请号：US13257315

申请日：2010-02-19

申请人： Bernhard Brendel ,  Holger Eggers ,  Adri J. Duijndam

发明人： Bernhard Brendel ,  Holger Eggers ,  Adri J. Duijndam

IPC分类号： G06K9/00

CPC分类号： G01R33/4828 ,  G01R33/56563

摘要： When distinguishing between fat and water in acquired MR data, a modified Dixon technique includes acquiring first and second signals Ii and I2, calculating the first and second components B and S of the signals Iχ and I2, where one of the first and second components corresponds to fat and the other corresponds to water, deriving two differential phase error candidates from them, and selecting a phase error candidate based on the assumption of smoothness of the disturbing field inhomogeneity. The exact determination of the absolute values of the water and fat components is then made by solving three signal equations for two variables that respectively correspond to water and fat, and is performed using for example a least square minimization with a Newton method.

摘要翻译： 在获取的MR数据中区分脂肪和水时，修改的Dixon技术包括获取第一和第二信号Ii和I2，计算信号Iχ和I2的第一和第二分量B和S，其中第一和第二分量中的一个对应于 脂肪，另一个对应于水，从它们中导出两个差分相位误差候选，并且基于干扰场不均匀性的平滑度的假设来选择相位误差候选。 然后通过求解分别对应于水和脂肪的两个变量的三个信号方程，并且使用例如使用牛顿法的最小二乘法来进行水和脂肪成分的绝对值的确切确定。

公开(公告)号：US20120089010A1

公开(公告)日：2012-04-12

申请号：US13377831

申请日：2010-06-23

申请人： Christoph Leussler ,  Peter Boernert ,  Daniel Wirtz ,  Bernd David ,  Holger Eggers ,  Jochen Keupp ,  Johannes Adrianus Overweg ,  Rainer Eckart

发明人： Christoph Leussler ,  Peter Boernert ,  Daniel Wirtz ,  Bernd David ,  Holger Eggers ,  Jochen Keupp ,  Johannes Adrianus Overweg ,  Rainer Eckart

IPC分类号： A61B5/055

CPC分类号： A61M16/10 ,  A61B5/055 ,  A61M16/14 ,  A61M2016/0015 ,  A61M2202/066

摘要： A dispenser (132), a magnetic resonance imaging system (100), and a method for using hyperpolarized contrast agent (304) during a magnetic resonance imaging examination. The dispenser comprises an attachment component (136) for a face piece (138). The face piece is adapted for receiving the surface of a subject (114) such that when the subject inhales hyperpolarized contrast agent enters the respiratory system of the subject. The dispenser further comprises a reservoir (300) adapted for receiving the hyperpolarized contrast agent. The dispenser further comprises a gas flow (406) tube connected to the attachment component and a vaporizer (406, 408, 412, 510, 602, 606) for vaporizing the hyperpolarized contrast agent in the gas flow tube into a hyperpolarized vapor. The dispenser further comprises a controller (402) for controlling when the vaporizer vaporizes the hyperpolarized contrast agent.

摘要翻译： 分配器（132），磁共振成像系统（100）以及在磁共振成像检查期间使用超极化造影剂（304）的方法。 分配器包括用于面件（138）的附接部件（136）。 面部件适于接纳被检体（114）的表面，使得当受试者吸入超极化造影剂进入受试者的呼吸系统时。 分配器还包括适于接收超极化造影剂的贮存器（300）。 分配器还包括连接到附接部件的气流（406）管和用于将气体流管中的超极化造影剂蒸发成超极化蒸气的蒸发器（406,408,412,510,602,606）。 分配器还包括控制器（402），用于控制何时蒸发器蒸发超极化造影剂。

公开(公告)号：US07440792B2

公开(公告)日：2008-10-21

申请号：US10544354

申请日：2004-01-30

申请人： Holger Eggers

发明人： Holger Eggers

IPC分类号： A61B5/05

CPC分类号： G01R33/287 ,  G01R33/4824 ,  G01R33/561

摘要： MR method for generating MR images of an object to be examined located inside an examination volume by means of an MR device and for simultaneously locating an interventional instrument inserted into the examination object, which instrument is equipped with a locating device. For the reconstruction of an MR image (20) MR signals together with device-delivered location signals from the examination volume are then recorded, after which the locating of the instrument takes place by the assessment of the image characteristics conditioned by the location signals. For making it possible to determine the position of the interventional instrument in an extremely rapid way, the invention proposes that the recording of the MR signals be effected by recording successively a plurality of MR partial data records (16, 17, 18) with respective incomplete and preferably non-cartesian sampling of the local frequency spectrum assigned to the examination volume. Two locating data records (21, 22) each are extracted from each of the MR partial data records (16, 17, 18). The actual locating of the instrument then takes place in that a difference image (33) is reconstructed from the two locating data records (21, 22).

摘要翻译： MR方法，用于通过MR装置产生位于检查体内的待检查对象的MR图像，并且用于同时定位插入到检查对象中的介入装置，该仪器配备有定位装置。 对于MR图像的重建（20），然后记录MR信号以及来自检查体积的装置传递的位置信号，之后通过评估由位置信号调节的图像特性来进行仪器的定位。 为了能够以极其快速的方式确定介入器具的位置，本发明提出通过连续记录具有各自不完全的多个MR部分数据记录（16,17,18）来实现MR信号的记录 并且优选地分配给检查体积的本地频谱的非笛卡尔采样。 从每个MR部分数据记录（16,17,18）中提取两个定位数据记录（21,22）。 然后发生仪器的实际定位，因为从两个定位数据记录（21,22）重建差分图像（33）。

公开(公告)号：US06576348B2

公开(公告)日：2003-06-10

申请号：US09826187

申请日：2001-04-04

申请人： Holger Eggers ,  Rudi Klein ,  Claudia Müller ,  Rainer Brandt

发明人： Holger Eggers ,  Rudi Klein ,  Claudia Müller ,  Rainer Brandt

IPC分类号： B32B2732

CPC分类号： B32B27/32 ,  B32B27/18 ,  B32B27/30 ,  Y10T428/1341 ,  Y10T428/1383 ,  Y10T428/2817 ,  Y10T428/31913 ,  Y10T428/31928

摘要： A multilayer film having a lamination side and a heat-sealable side is described. The multilayer film comprises, a) an inner layer (i) ethylene/vinyl alcohol copolymer; b) a coupling agent layer (ii) and a separate coupling agent layer (ii′), said inner layer (i) being interposed between and in contact with each of said coupling agent layer (ii) and said separate coupling agent layer (ii′); c) at least one further layer (iii), said separate coupling agent layer (ii′) being interposed between and in contact with each of said inner layer (i) and said layer (iii); d) at least one layer (iv), said coupling agent layer (ii) being interposed between and in contact with each of said inner layer (i) and said layer (iv); and e) a heat-sealable layer (v), said layer (iv) being interposed between and in contact with each of said coupling agent layer (ii) and said heat-sealable layer (v). Layers (i), (ii), (ii′), (iii) and (v) of the multilayer film contain 0.1 to 3 wt. % of a sorbitan monoester, based on the total weight of said multilayer film. Layer (iii) defines the lamination side of the multilayer film, and the heat-sealable layer (v) defines the heat-sealable side of the multilayer film. Packaging materials comprising the multilayer film are also described.

公开(公告)号：US09753109B2

公开(公告)日：2017-09-05

申请号：US13577266

申请日：2011-02-16

申请人： Holger Eggers

发明人： Holger Eggers

IPC分类号： G01R33/48 ,  G01R33/561 ,  G01N24/08

CPC分类号： G01R33/4828 ,  G01N24/08 ,  G01N24/088 ,  G01R33/5615

摘要： At least two chemical species are imaged using magnetic resonance imaging with signal separation for two chemical species resulting in separate signal datasets for these two chemical species. First and second echo data are acquired at different echo times resulting in a first and second acquired complex dataset. The first and second acquired datasets are modelled by employing a spectral signal model of at least one of the chemical species. The modelling results in a first and second modelled complex dataset. The first and second modelled datasets include a first and second phase error and the separate signal datasets for the two chemical species. From the first and second acquired dataset and the first and second modelled dataset the separate signal datasets for the two chemical species are determined.

公开(公告)号：US20130176027A1

公开(公告)日：2013-07-11

申请号：US13823766

申请日：2011-09-20

申请人： Holger Eggers

发明人： Holger Eggers

IPC分类号： G01R33/48

CPC分类号： G01R33/4818 ,  G01R33/4828

摘要： The invention relates to a method of imaging at least two chemical species using magnetic resonance imaging with signal separation for the two chemical species, the method comprising:—acquiring first and second echo data at different echo times resulting in a first and second acquired complex dataset,—modelling the first and second acquired dataset, said modelling comprising a spectral signal model of at least one of the chemical species,—identifying in the first and second acquired dataset the voxels for which the modelling yields a single, unambiguous mathematical solution for the signal separation, and—resolving the ambiguity for the voxels for which the modelling yields more than one mathematical solution, if any such voxels remain.

摘要翻译： 本发明涉及使用两个化学物种的信号分离的磁共振成像来成像至少两种化学物质的方法，所述方法包括： - 在不同回波时间获取第一和第二回波数据，得到第一和第二获得的复数数据集 - 建模第一和第二获取的数据集，所述建模包括至少一个化学物质的光谱信号模型， - 识别在第一和第二获取的数据集中的体素，其中模型产生单个的，明确的数学解 信号分离，并且解析模型产生多于一种数学解的体素的模糊度，如果有这样的体素保留。

公开(公告)号：US20120295070A1

公开(公告)日：2012-11-22

申请号：US13509048

申请日：2010-11-09

申请人： Holger Eggers

发明人： Holger Eggers

IPC分类号： B32B3/26 ,  B32B3/30 ,  B32B3/10

CPC分类号： B32B27/08 ,  A01F25/13 ,  B32B5/02 ,  B32B5/022 ,  B32B5/024 ,  B32B5/028 ,  B32B7/12 ,  B32B27/30 ,  B32B27/306 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B2262/02 ,  B32B2262/0253 ,  B32B2264/10 ,  B32B2264/104 ,  B32B2270/00 ,  B32B2307/712 ,  B32B2307/726 ,  B32B2307/732 ,  B32B2307/75 ,  B32B2410/00 ,  Y10T428/24612 ,  Y10T428/24802 ,  Y10T428/249981 ,  Y10T428/249993 ,  Y10T442/10 ,  Y10T442/20 ,  Y10T442/3862 ,  Y10T442/387 ,  Y10T442/3886 ,  Y10T442/3894 ,  Y10T442/674 ,  Y10T442/675 ,  Y10T442/676 ,  Y10T442/678

摘要： The present invention relates to silo covers comprising at least two layers, wherein an inner first layer facing the silo is a single- or multi-ply plastic film having oxygen permeability according to DIN 53380-3 at 23° C. and 50% relative humidity of no more than 500 cm3/(m2 d bar) and a water vapor transmission rate according to ISO 15106-3 at 23 ° C. and 85% relative humidity of at least 5 g/(m2 d), and in at least one ply in total contains at least 50% by weight of one or more materials from the group comprising polyamide, copolyamide, polyester, copolyester, polyethylene vinyl alcohol, polyvinyl alcohol and mixtures thereof, and at least one second layer, which is located on top of the inner layer and is separate from the inner layer, or easy to separate therefrom, or self-separating on the silo, composed of at least 70% by weight of materials from the group comprising polyethylene, polypropylene, copolymers of ethylene and other vinyl monomers, and copolymers made of propylene and other vinyl monomers.

摘要翻译： 本发明涉及包括至少两层的料仓盖，其中面向料仓的内部第一层是在23℃和50％相对湿度下根据DIN 53380-3具有氧气渗透性的单层或多层塑料膜 在不超过500cm 3 /（m 2 d bar）的情况下，根据ISO 15106-3在23℃和85％相对湿度下的水蒸气透过率为至少5g /（m 2 d），并且在至少一个 总共包含至少50重量％的一种或多种来自包含聚酰胺，共聚酰胺，聚酯，共聚酯，聚乙烯醇，聚乙烯醇及其混合物的材料的材料，以及至少一个第二层，其位于 所述内层与所述内层分离，或易于与其分离，或在筒仓上自分离，由至少70重量％的由聚乙烯，聚丙烯，乙烯和其它乙烯基单体的共聚物组成的材料组成 ，和由丙烯制成的共聚物 和其它乙烯基单体。

公开(公告)号：US06270882B1

公开(公告)日：2001-08-07

申请号：US09203831

申请日：1998-12-01

申请人： Holger Eggers ,  Klaus Lund ,  Rainer Brandt ,  Bernd Sperlich

发明人： Holger Eggers ,  Klaus Lund ,  Rainer Brandt ,  Bernd Sperlich

IPC分类号： B32B702

CPC分类号： B32B27/08 ,  Y10T428/2495 ,  Y10T428/31743 ,  Y10T428/31746 ,  Y10T428/3175 ,  Y10T428/31757

摘要： The present invention relates to a heat sealable, unoriented multi-layer film consisting of a sequence of layers (I) comprising one or more plies on the outer side of the film, a sequence of layers (II) also comprising at least one ply, denoted the heat sealable layer, on the other outer side of the film, optionally together with a coupling sequence of layers (III), also of one or more plies, between the sequences of layers (I) and (II), wherein the multi-layer film is characterized in that the sequence of layers (I) contains at least one layer (i) of a linear alternating copolymer (1) of carbon monoxide and at least one ethylenically unsaturated olefin, optionally together with one or more layers (ii) containing polyamide, characterised in that the ratio between the thicknesses of the sequence of layers (I) and the total multi-layer film is no greater than 0.6 and no less than 0.15, that the total thickness of the multi-layer film is no less than 50 and no more than 300 &mgr;m, and that at least one melting point, determined using the DSC method to ASTM 3418, of one of the polymeric components present in the sequence of layers (II) is at least 50° C. lower than at least one melting point, determined using the DSC method to ASTM 3418, of one of the polymers present in the sequence of layers (I).

摘要翻译： 本发明涉及一种可热封的，未取向的多层膜，其由在膜的外侧上包括一个或多个层的层序列（I）组成，层序列（II）还包括至少一层， 表示可热封层，在膜的另一个外侧，任选地与层（I）和（II）的序列之间的层（III）的层叠（III）也是一层或多层，其中多层 其特征在于，层（I）的顺序包含至少一层线性交替共聚物（1）的一氧化碳和至少一种烯键式不饱和烯烃的层（i），任选地与一个或多个层（ii ），其特征在于，层（I）和多层膜的层序的厚度之比不大于0.6且不小于0.15，多层膜的总厚度不为 小于50，不超过300个妈妈 使用层析（II）序列中存在的聚合物组分之一的ASTM 3418的DSC法测定的至少一个熔点比使用DSC法测定的至少一个熔点低至少50℃ 按照ASTM 3418，存在于层（I）序列中的聚合物之一。

公开(公告)号：US07309985B2

公开(公告)日：2007-12-18

申请号：US10554121

申请日：2004-04-14

申请人： Holger Eggers ,  Peter Boernert

发明人： Holger Eggers ,  Peter Boernert

IPC分类号： G01V3/00

CPC分类号： G01R33/5611

摘要： An MR image (14) is reconstructed from MR signals (1, 2, 3, 4) that are acquired in parallel by a plurality of receiving coils (5, 6, 7, 8) with incomplete sampling of the spatial frequency space. The reconstructed MR image (14) is calculated iteratively as the solution of a system of linear equations. To provide a more highly developed method for parallel SENSE imaging, an iteration process (15) begins with a starting image (9) which approximates to the MR image to be reconstructed (14), in such a way that undersampling artifacts are suppressed in the intermediate solutions of the system of equations that are obtained during the course of the iteration process.

摘要翻译： 由MR空间频率空间的不完全采样的多个接收线圈（5,6,7,8）并行获取的MR信号（1,2,3,4）重构MR图像（14）。 重建的MR图像（14）被迭代地计算为线性方程组的解。 为了提供一种用于并行SENSE成像的更高度发展的方法，迭代过程（15）从逼近要重建的MR图像（14）的开始图像（9）开始，以使得在 在迭代过程中获得的方程组的中间解。