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    Compounds and methods for treatment of amyloid-beta-peptide related disorders
    1.
    发明申请
    Compounds and methods for treatment of amyloid-beta-peptide related disorders 审中-公开
    用于治疗淀粉样蛋白-β-肽相关病症的化合物和方法

    公开(公告)号：US20090118282A1

    公开(公告)日：2009-05-07

    申请号：US11989024

    申请日：2006-07-21

    申请人： Bertrand Leblond ,  Eric Beausoleil ,  Thierry Taverne ,  Laurent Desire ,  Fabien Schweighoffer

    发明人： Bertrand Leblond ,  Eric Beausoleil ,  Thierry Taverne ,  Laurent Desire ,  Fabien Schweighoffer

    IPC分类号： A61K31/4709 ,  C07D401/12 ,  C07D413/12 ,  C07D215/36 ,  A61P25/28 ,  A61K31/47 ,  C07D471/04 ,  A61K31/5377

    CPC分类号： C07D215/36 ,  C07D401/12

    摘要： The present invention relates to compounds, preparation and uses thereof, particularly in the pharmaceutical industry. The present invention discloses novel compounds more particularly useful for the treatment of Alzheimer's disease and other similar diseases, and more specifically the inventive compounds modulate (in particular, inhibit) the level of amyloid-β peptide (Aβ) exhibited by cells or tissues; Aβ peptide is a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. This invention also relates the use of these inhibitors to prevent, treat or ameliorate the symptoms of Alzheimer's disease or any Amyloid-β-Peptide Related Disorder.

    摘要翻译： 本发明涉及化合物，其制备和用途，特别是在制药工业中。 本发明公开了更特别可用于治疗阿尔茨海默病和其他类似疾病的新化合物，更具体地说，本发明化合物调节（特别是抑制）细胞或组织表现的淀粉样蛋白-β肽（Abeta）的水平; Abeta肽是阿尔茨海默氏症患者大脑中发现的淀粉样蛋白斑的主要成分。 本发明还涉及这些抑制剂用于预防，治疗或改善阿尔茨海默病或任何淀粉样蛋白-β-肽相关疾病症状的用途。

    Methods of treating nervous disorders
    3.
    发明申请
    Methods of treating nervous disorders 审中-公开
    治疗神经障碍的方法

    公开(公告)号：US20070027146A1

    公开(公告)日：2007-02-01

    申请号：US11190070

    申请日：2005-07-27

    申请人： Laurent Desire ,  Bertrand Leblond ,  Eric Beausoleil ,  Thierry Taverne ,  Fabien Schweighoffer

    发明人： Laurent Desire ,  Bertrand Leblond ,  Eric Beausoleil ,  Thierry Taverne ,  Fabien Schweighoffer

    IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4709

    CPC分类号： A61K31/5375 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/541

    摘要： The invention relates to compositions and methods for treating nervous disorders. More particularly, the invention relates to methods of treating amyloïd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1 inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloïd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac1.

    摘要翻译： 本发明涉及用于治疗神经障碍的组合物和方法。 更具体地，本发明涉及使用Rac1抑制剂治疗淀粉样肽相关病症，特别是阿尔茨海默氏病的方法。 本发明可用于哺乳动物受试者，特别是人类受试者，在疾病的各个阶段，包括发病。 本发明还提供了基于测定化合物抑制Rac1的能力的测定来制备，鉴定，选择或优化化合物用于治疗淀粉样肽相关病症的方法。

    Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
    5.
    发明授权
    Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis 失效
    治疗细胞增殖性疾病，视网膜病变和关节炎的化合物和方法

    公开(公告)号：US07514432B2

    公开(公告)日：2009-04-07

    申请号：US10541328

    申请日：2004-02-27

    申请人： Bertrand Leblond ,  Silvère Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    发明人： Bertrand Leblond ,  Silvère Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    IPC分类号： A61K31/5377 ,  C07D413/14

    CPC分类号： C07D405/12 ,  C07D411/12

    摘要： The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.

    摘要翻译： 本发明涉及化合物及其用途，特别是在制药工业中。 本发明公开了具有抗增殖和抗血管生成活性的化合物，以及用于治疗与异常细胞增殖相关的各种疾病（包括癌症）或与不稳定的血管生成相关的方法，包括实体瘤，眼部疾病，特别是视网膜病变或关节炎的生长和转移 ，通过施用所述化合物。 它还涉及包含所述化合物的药物组合物，更特别可用于治疗癌症（如白血病），眼部疾病和关节炎。

    Novel compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
    6.
    发明申请
    Novel compounds and methods of treating cell proliferative diseases, retinopathies and arthritis 失效
    新型化合物和治疗细胞增殖性疾病，视网膜病和关节炎的方法

    公开(公告)号：US20060183749A1

    公开(公告)日：2006-08-17

    申请号：US10541328

    申请日：2004-02-27

    申请人： Bertrand Leblond ,  Silvere Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    发明人： Bertrand Leblond ,  Silvere Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    IPC分类号： A61K31/496 ,  A61K31/4709 ,  C07D405/02

    CPC分类号： C07D405/12 ,  C07D411/12

    摘要： The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.

    摘要翻译： 本发明涉及化合物及其用途，特别是在制药工业中。 本发明公开了具有抗增殖和抗血管生成活性的化合物，以及用于治疗与异常细胞增殖相关的各种疾病（包括癌症）或与不稳定的血管生成相关的方法，包括实体瘤，眼部疾病，特别是视网膜病变或关节炎的生长和转移 ，通过施用所述化合物。 它还涉及包含所述化合物的药物组合物，更特别可用于治疗癌症（如白血病），眼部疾病和关节炎。