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    Cerium Oxide Nanoparticles for Treatment and Prevention of Alzheimer's Disease, Parkinson's Disease, and Disorders Associated with Free Radical Production and/or Mitochondrial Dysfunction
    2.
    发明申请
    Cerium Oxide Nanoparticles for Treatment and Prevention of Alzheimer's Disease, Parkinson's Disease, and Disorders Associated with Free Radical Production and/or Mitochondrial Dysfunction 审中-公开
    用于治疗和预防阿尔茨海默病，帕金森病和与自由基生成和/或线粒体功能障碍相关的疾病的氧化铈纳米颗粒

    公开(公告)号：US20090092671A1

    公开(公告)日：2009-04-09

    申请号：US12252905

    申请日：2008-10-16

    申请人： Beverly A. Rzigalinski ,  Neeraj Singh ,  Courtney A. Cohen

    发明人： Beverly A. Rzigalinski ,  Neeraj Singh ,  Courtney A. Cohen

    IPC分类号： A61K9/14 ,  A61K33/24 ,  C01F17/00 ,  A61P25/28

    CPC分类号： A61K33/24 ,  A61K9/14

    摘要： Cerium oxide nanoparticles (CeONP) can be used to treat or prevent neurodegenerative diseases, including for example Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, AIDS-related dementia, ALS, progressive supranuclear palsy, and encephalitis, as well as mitochondrial diseases and diseases associated with mitochondrial damage. In particular, CeONP having an average size of about 2 nm to about 100 nm can be administered in an amount sufficient to block production of hydroxyl or superoxide radicals, block free radical production by Aβ(1-42), block Aβ(1-42)-induced neuronal death, block Aβ(1-42)-induced [Ca2+]i dysfunction in neurons, block Aβ(1-42)-induced lipid peroxidation, decrease loss of dopaminergic neurotransmission, or reduce mitochondrial dysfunction in a cell. CeONP can also be effective in treating conditions involving toxic exposures to compounds that induce mitochondrial dysfunction, such as rotenone, cyanide, carbon monoxide, polychlorinated biphenyls (PCBs) and other mitochondrial toxins.

    摘要翻译： 氧化铈纳米粒子（CeONP）可用于治疗或预防神经变性疾病，包括阿尔茨海默氏病，帕金森病，亨廷顿病，AIDS相关性痴呆，ALS，进行性核上性麻痹和脑炎，以及线粒体疾病和相关疾病 线粒体损伤。 特别地，具有约2nm至约100nm的平均尺寸的CeONP可以以足以阻断羟基或超氧化物自由基的产生的量施用，阻断Aβ（1-42），Abeta（1-42） ）诱导的神经元死亡，阻断Abeta（1-42）诱导的神经元中的[Ca2 +] i功能障碍，阻断Abeta（1-42）诱导的脂质过氧化，减少多巴胺能神经传递的损失或减少细胞中的线粒体功能障碍。 CeONP还可以有效地治疗引起线粒体功能障碍的化合物的毒性暴露的病症，例如鱼藤酮，氰化物，一氧化碳，多氯联苯（PCBs）和其他线粒体毒素。

    System and method for immunosensor regeneration
    10.
    发明授权
    System and method for immunosensor regeneration 失效
    免疫传感器再生的系统和方法

    公开(公告)号：US07118922B1

    公开(公告)日：2006-10-10

    申请号：US10710986

    申请日：2004-08-16

    申请人： Shekhar Bhansali ,  Beverly A. Rzigalinski ,  Hyoungjin Cho

    发明人： Shekhar Bhansali ,  Beverly A. Rzigalinski ,  Hyoungjin Cho

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54373

    摘要： The present invention allows for regeneration of any chemical and biological sensor systems without totally destroying the primary antibodies in the system. The present invention provides regeneration of the sensor by debinding of the antigen/antibody complex utilizing a controlled electrical impulse. The technique is generic and can be used with most immunoassay-based detectors.

    摘要翻译： 本发明允许任何化学和生物传感器系统的再生，而不会完全破坏系统中的一抗。 本发明通过使用受控电脉冲去除抗原/抗体复合物来提供传感器的再生。 该技术是通用的，可以与大多数基于免疫分析的检测器一起使用。