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1.发明授权公开(公告)号：US08068909B2
公开(公告)日：2011-11-29
申请号：US11769402
申请日：2007-06-27
申请人： Bin Mi , Yongxing Zhang , Yunlong Zhang , James O. Gilkerson
发明人： Bin Mi , Yongxing Zhang , Yunlong Zhang , James O. Gilkerson
IPC分类号： A61B5/02
CPC分类号： A61N1/056 , A61B5/02438 , A61B5/02444 , A61B5/6846 , A61B5/6851 , A61N1/36514 , A61N1/36578
摘要： Embodiments of the invention are related to implantable devices including movement sensors and related methods for measuring cardiac performance, amongst other things. In an embodiment, the invention includes an implantable electrical stimulation lead. The electrical stimulation lead can include a lead body having a proximal end and a distal end and a sheath defining a central lumen. The lead body can further include an electrical conductor disposed within the central lumen of the sheath. The stimulation lead can further include a stimulation electrode positioned at the distal end of the lead body, the stimulation electrode in electrical communication with the electrical conductor. The electrical stimulation lead can include an flexion sensor coupled to the lead body, the movement sensor configured to generate a signal in response to movement of the lead body. In an embodiment, the invention includes a method of monitoring the condition of a heart failure patient. In an embodiment, the invention includes a method of treating unstable arrhythmia in a patient. Other embodiments are also included herein.
摘要翻译： 本发明的实施例涉及包括运动传感器和用于测量心脏性能的相关方法的可植入装置。 在一个实施例中，本发明包括可植入电刺激引线。 电刺激引线可以包括具有近端和远端的引线主体和限定中心内腔的护套。 引线体还可以包括设置在护套的中心腔内的电导体。 刺激引线还可以包括位于引线体的远端处的刺激电极，该刺激电极与电导体电连通。 电刺激引线可以包括耦合到引线主体的屈曲传感器，所述运动传感器被配置为响应于引线主体的移动而产生信号。 在一个实施例中，本发明包括监测心力衰竭患者状况的方法。 在一个实施方案中，本发明包括治疗患者不稳定性心律失常的方法。 本文还包括其它实施例。
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2.发明申请公开(公告)号：US20090005829A1
公开(公告)日：2009-01-01
申请号：US11769402
申请日：2007-06-27
申请人： Bin Mi , Yongxing Zhang , Yunlong Zhang , James O. Gilkerson
发明人： Bin Mi , Yongxing Zhang , Yunlong Zhang , James O. Gilkerson
CPC分类号： A61N1/056 , A61B5/02438 , A61B5/02444 , A61B5/6846 , A61B5/6851 , A61N1/36514 , A61N1/36578
摘要： Embodiments of the invention are related to implantable devices including movement sensors and related methods for measuring cardiac performance, amongst other things. In an embodiment, the invention includes an implantable electrical stimulation lead. The electrical stimulation lead can include a lead body having a proximal end and a distal end and a sheath defining a central lumen. The lead body can further include an electrical conductor disposed within the central lumen of the sheath. The stimulation lead can further include a stimulation electrode positioned at the distal end of the lead body, the stimulation electrode in electrical communication with the electrical conductor. The electrical stimulation lead can include an flexion sensor coupled to the lead body, the movement sensor configured to generate a signal in response to movement of the lead body. In an embodiment, the invention includes a method of monitoring the condition of a heart failure patient. In an embodiment, the invention includes a method of treating unstable arrhythmia in a patient. Other embodiments are also included herein.
摘要翻译： 本发明的实施例涉及包括运动传感器和用于测量心脏性能的相关方法的可植入装置。 在一个实施例中，本发明包括可植入电刺激引线。 电刺激引线可以包括具有近端和远端的引线主体和限定中心内腔的护套。 引线体还可以包括设置在护套的中心腔内的电导体。 刺激引线还可以包括位于引线体的远端处的刺激电极，该刺激电极与电导体电连通。 电刺激引线可以包括耦合到引线主体的屈曲传感器，所述运动传感器被配置为响应于引线主体的移动而产生信号。 在一个实施例中，本发明包括监测心力衰竭患者状况的方法。 在一个实施方案中，本发明包括治疗患者不稳定性心律失常的方法。 本文还包括其它实施例。
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3.发明授权公开(公告)号：US07328063B2
公开(公告)日：2008-02-05
申请号：US11000133
申请日：2004-11-30
IPC分类号： A61B5/04
CPC分类号： A61N1/3622 , A61B5/0452 , A61B5/7264 , A61N1/3956
摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.
摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。
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4.发明申请METHOD AND APPARATUS FOR ARRHYTHMIA CLASSIFICATION USING ATRIAL SIGNAL MAPPING 有权方法和装置使用ATRIAL信号映射进行ARRHYTHMIA分类公开(公告)号：US20120046565A1
公开(公告)日：2012-02-23
申请号：US13286435
申请日：2011-11-01
IPC分类号： A61B5/0464 , A61B5/0468
CPC分类号： A61N1/3622 , A61B5/0452 , A61B5/7264 , A61N1/3956
摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.
摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。
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公开(公告)号：US08494618B2
公开(公告)日：2013-07-23
申请号：US11208922
申请日：2005-08-22
申请人： Yunlong Zhang , James O. Gilkerson , Yongxing Zhang , Boyce Moon
发明人： Yunlong Zhang , James O. Gilkerson , Yongxing Zhang , Boyce Moon
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/36521 , A61N1/3925
摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.
摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。
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6.发明授权公开(公告)号：US08768444B2
公开(公告)日：2014-07-01
申请号：US13286435
申请日：2011-11-01
IPC分类号： A61B5/04
CPC分类号： A61N1/3622 , A61B5/0452 , A61B5/7264 , A61N1/3956
摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.
摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。
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7.发明授权Implantable medical device for generating cardiac pressure-volume loop and optimizing therapy 有权用于产生心脏压力 - 体积循环和优化治疗的植入式医疗装置公开(公告)号：US07580746B2
公开(公告)日：2009-08-25
申请号：US11296732
申请日：2005-12-07
申请人： James O. Gilkerson , Yongxing Zhang , Yunlong Zhang , Sophia Wang
发明人： James O. Gilkerson , Yongxing Zhang , Yunlong Zhang , Sophia Wang
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/3962
摘要： An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.
摘要翻译： 一种用于产生心脏压力 - 体积回路的可植入医疗装置，所述可植入医疗装置包括脉冲发生器，所述脉冲发生器包括控制电路，包括近端和远端的第一心脏引线，并且在近端处耦合到所述脉冲发生器， 电极，位于心脏引线的远端并且可操作地耦合到控制电路，操作地耦合到控制电路的声音传感器和可操作地耦合到控制电路的压力传感器，其中可植入医疗装置适于测量心内阻抗 。 一种使用可植入医疗装置来优化递送至心脏的治疗的方法。
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8.发明申请公开(公告)号：US20090093729A1
公开(公告)日：2009-04-09
申请号：US11866523
申请日：2007-10-03
申请人： Yunlong Zhang , Bin Mi , Yongxing Zhang
发明人： Yunlong Zhang , Bin Mi , Yongxing Zhang
IPC分类号： A61B5/0215
CPC分类号： A61B5/02158 , A61B5/02007 , A61B5/02125 , A61B5/0285 , A61B5/029 , A61B5/1107 , A61B5/6876 , A61B5/6884 , A61B2562/0261 , A61B2562/0266
摘要： Embodiments of the invention are related to devices and methods for measuring arterial elasticity and/or blood pressure, amongst other things. In an embodiment, the invention includes an implantable medical device having a sensor element that is configured to engage a vessel of a patient. The sensor element is further configured to generate a signal in response to bending of the sensor element, where bending occurs as a result of changes in the pressure within the vessel. The implantable medical device further includes a controller in signal communication with the sensor element, where the controller is configured to store information regarding the signal generated by the sensor element. Other embodiments are also included herein.
摘要翻译： 本发明的实施例涉及用于测量动脉弹性和/或血压的装置和方法等。 在一个实施例中，本发明包括具有传感器元件的可植入医疗装置，该传感器元件构造成与患者的血管接合。 传感器元件还被配置为响应于传感器元件的弯曲而产生信号，其中由于容器内的压力变化而发生弯曲。 可植入医疗装置还包括与传感器元件信号通信的控制器，其中控制器被配置为存储关于由传感器元件产生的信号的信息。 本文还包括其它实施例。
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公开(公告)号：US20080262586A1
公开(公告)日：2008-10-23
申请号：US12144247
申请日：2008-06-23
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/056 , A61N2001/0585
摘要： A pacing lead having a lead body configured into a pre-formed J-shape. The lead includes a pacing electrode coupled to an intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead is adapted to be placed within a heart in a J-shaped configuration with the electrode positioned proximate a ventricular septum or a right ventricular outflow tract such that at least a portion of the distal end of the lead body is located within a pulmonary artery. In one embodiment, the distal end of the lead is configured to be passively fixated within the pulmonary artery. Another aspect includes a lead body wherein a section of the intermediate portion of the lead body is less stiff than adjacent sections of the lead body. The lead includes a pacing electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section. The lead is adapted to be placed within a heart in a J-shaped configuration with the less stiff section near a bottom of the J-shape such that the electrode is positioned proximate a ventricular septum or a right ventricular outflow tract and at least a portion of the distal end of the lead body is fixated within a pulmonary artery.
摘要翻译： 具有构造成预成形的J形的引线主体的起搏引线。 引线包括连接到引线主体的中间部分并且位于远离预成形的J形的底部的起搏电极。 引线适于放置在J形构型的心脏内，其中电极位于心室隔膜或右心室流出道附近，使得引线体的远端的至少一部分位于肺动脉内 。 在一个实施例中，引线的远端构造成被动地固定在肺动脉内。 另一方面包括引线体，其中引线主体的中间部分的部分比引线本体的相邻部分刚性差。 引线包括连接到引线主体的中间部分并位于较不硬的部分的远侧的起搏电极。 引线适于放置在心脏内的J形构型中，具有靠近J形底部的较硬的部分，使得电极位于靠近心室隔膜或右心室流出道和至少一部分 引导体的远端固定在肺动脉内。
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10.发明授权Implantable lead for septal placement of electrode with fixation mechanism in the pulmonary artery 失效在肺动脉中具有固定机制的电极间隔放置的植入性铅公开(公告)号：US07890188B2
公开(公告)日：2011-02-15
申请号：US10325658
申请日：2002-12-19
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead body includes an electrode coupled to an intermediate portion of the lead body. A distal end of the lead includes a pre-formed, biased shape adapted to passively fixate the distal end of the lead within a pulmonary artery with the electrode positioned in the right ventricle or ventricular outflow tract. The lead body can include a preformed J-shape, with the electrode coupled to the intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead body can include a section of the intermediate portion of the lead body being less stiff than adjacent sections of the lead body with the electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section.
摘要翻译： 引线体包括连接到引线主体的中间部分的电极。 引线的远端包括预先形成的偏压形状，其适于被动地固定在肺动脉内的引线的远端，其中电极定位在右心室或心室流出道中。 引线体可以包括预成型的J形，电极耦合到引线本体的中间部分并且位于远离预成形的J形的底部。 引线主体可以包括引线主体的中间部分的一部分比引线主体的相邻部分刚性差，其中电极耦合到引线主体的中间部分并且位于较硬的部分的远侧。
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