-
公开(公告)号:US07696352B2
公开(公告)日:2010-04-13
申请号:US11620615
申请日:2007-01-05
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough , Carroll Anna Crew Scarborough, legal representative
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: C07D409/14 , C07D401/14 , C07D409/12 , A61K31/4436
CPC分类号: C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,酯或前药,其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US20100234352A1
公开(公告)日:2010-09-16
申请号:US12697135
申请日:2010-01-29
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/55 , A61K31/497 , A61K31/513 , A61K31/501 , A61K31/551 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/4178 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/538 , A61K31/4709 , A61P7/02 , A61P9/00
CPC分类号: C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,酯或前药,其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US08153670B2
公开(公告)日:2012-04-10
申请号:US12348879
申请日:2009-01-05
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US20120178733A1
公开(公告)日:2012-07-12
申请号:US13213927
申请日:2011-08-19
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/422 , C07D413/14 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K31/4545 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D417/14 , A61K31/541 , A61K31/553 , A61K31/551 , C07D409/14 , C07D409/12 , A61K31/4192 , C07D417/12 , A61K31/427 , A61K31/4178 , A61K31/4709 , A61P9/00 , A61P9/10 , A01N1/02 , A61P7/02 , C07D413/12
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US07521470B2
公开(公告)日:2009-04-21
申请号:US11158274
申请日:2005-06-20
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US20090298806A1
公开(公告)日:2009-12-03
申请号:US12348879
申请日:2009-01-05
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/422 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/454 , A61K31/55 , A61K31/5377 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/553 , A61P9/00
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US08377974B2
公开(公告)日:2013-02-19
申请号:US13213927
申请日:2011-08-19
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , C07D233/64 , C07D231/12 , C07D207/34
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
-
公开(公告)号:US20070185092A1
公开(公告)日:2007-08-09
申请号:US11620615
申请日:2007-01-05
申请人: Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Yonghong Song , Gary Probst , Yanchen Zhang , Robert Scarborough
发明人: Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Yonghong Song , Gary Probst , Yanchen Zhang , Robert Scarborough
IPC分类号: A61K31/551 , A61K31/502 , A61K31/513 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , C07D409/14
CPC分类号: C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,酯或前药,其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
公开(公告)号:US08518977B2
公开(公告)日:2013-08-27
申请号:US13247937
申请日:2011-09-28
申请人: Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人: Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号: C07D213/75 , A61K31/44
CPC分类号: A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要: Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物,包括其药学上可接受的异构体,盐,水合物,溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
-
公开(公告)号:US07678913B2
公开(公告)日:2010-03-16
申请号:US11298317
申请日:2005-12-07
IPC分类号: A61K31/48 , C07D207/40 , C07D215/38
CPC分类号: C07D213/40 , C07C275/30 , C07D211/26 , C07D211/58 , C07D213/64 , C07D213/74 , C07D213/89 , C07D215/227 , C07D233/24 , C07D233/64 , C07D243/08 , C07D263/04 , C07D265/32 , C07D277/04 , C07D295/195 , C07D333/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
-
-
-
-
-
-
-
-