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公开(公告)号：US06545055B1
公开(公告)日：2003-04-08
申请号：US09576638
申请日：2000-05-24
IPC分类号： A61K3118
CPC分类号： C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：US06534535B1
公开(公告)日：2003-03-18
申请号：US09636804
申请日：2000-08-10
申请人： Bing-Yan Zhu , Robert M. Scarborough , Lane Clizbe , Brandon Doughan , Zhaozhong Jon Jia , Kim Kane-Maguire , Charles Marlowe , Yonghong Song , Ting Su , Willy Teng , Penglie Zhang
发明人： Bing-Yan Zhu , Robert M. Scarborough , Lane Clizbe , Brandon Doughan , Zhaozhong Jon Jia , Kim Kane-Maguire , Charles Marlowe , Yonghong Song , Ting Su , Willy Teng , Penglie Zhang
IPC分类号： A61K3140
CPC分类号： C07D215/227 , C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) below: are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 以下式（I）的化合物：在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US06399627B1
公开(公告)日：2002-06-04
申请号：US09501371
申请日：2000-02-11
申请人： Yonghong Song , Bing-Yan Zhu , Robert M. Scarborough , Lane Clizbe , Zhaozhong Jon Jia , Ting Su , Willy Teng
发明人： Yonghong Song , Bing-Yan Zhu , Robert M. Scarborough , Lane Clizbe , Zhaozhong Jon Jia , Ting Su , Willy Teng
IPC分类号： A61K3147
CPC分类号： C07D231/12 , C07C311/46 , C07C311/51 , C07C2601/10 , C07D217/22 , C07D233/56 , C07D239/94 , C07D249/08 , C07D307/54 , C07D401/12
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US06720317B1
公开(公告)日：2004-04-13
申请号：US09662807
申请日：2000-09-15
申请人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
发明人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
IPC分类号： C07D23114
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US06686368B1
公开(公告)日：2004-02-03
申请号：US10387927
申请日：2003-03-12
申请人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
发明人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
IPC分类号： C07D40112
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：US06632815B2
公开(公告)日：2003-10-14
申请号：US09794214
申请日：2001-02-28
申请人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
发明人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
IPC分类号： C07D23112
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D231/14 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 这些化合物在体外或体内可用于预防或治疗凝血障碍
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公开(公告)号：US07312235B2
公开(公告)日：2007-12-25
申请号：US10115135
申请日：2002-04-01
申请人： Bing-Yan Zhu , Penglie Zhang , Erick A. Goldman , Zhaozhong Jon Jia , Shawn Bauer , Wenrong Huang , John Woolfrey , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Erick A. Goldman , Zhaozhong Jon Jia , Shawn Bauer , Wenrong Huang , John Woolfrey , Robert M. Scarborough
IPC分类号： A61K31/497 , A61K31/445 , A61K31/44 , A61K31/00
CPC分类号： C07D213/75 , C07C237/42 , C07C255/57 , C07C257/18 , C07D205/04 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/62 , C07D233/22 , C07D233/64 , C07D295/13 , C07D295/195 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , G02B6/2746
摘要： Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型苯甲酰胺化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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