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公开(公告)号：US12227792B2
公开(公告)日：2025-02-18
申请号：US18381371
申请日：2023-10-18
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti , George Karlin-Neumann
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/682 , C12Q1/6832 , C12Q1/6853 , C12Q1/686
Abstract: Improved multiple displacement amplification (MDA) reagents and methods are provided.
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公开(公告)号：US11952610B2
公开(公告)日：2024-04-09
申请号：US17686466
申请日：2022-03-04
Applicant: BIO-RAD EUROPE GMBH , BIO-RAD LABORATORIES, INC.
Inventor： Christophe Quiring , Christine Favier , Patrice Sarfati , Jean Francois Mouscadet , Ronald Lebofsky , Rebecca Dievart
CPC classification number: C12Q1/06 , C12N9/2428 , C12N9/2445 , C12N9/2465 , C12N9/2471 , C12N9/2474 , C12N9/485 , C12Q1/04 , C12Q1/045 , C12Y302/01003 , C12Y302/01022 , C12Y302/01035 , C12Y304/11
Abstract: Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.
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公开(公告)号：US20230417765A1
公开(公告)日：2023-12-28
申请号：US18354151
申请日：2023-07-18
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jeremy Agresti , Ronald Lebofsky
IPC: G01N33/68 , C12Q1/6816 , B01J19/00 , C12Q1/6869
CPC classification number: G01N33/6878 , C12Q1/6816 , B01J19/0046 , C12Q1/6869 , C40B70/00
Abstract: Methods and compositions are described for single cell resolution, quantitative proteomic analysis using high throughput sequencing.
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公开(公告)号：US20220111380A1
公开(公告)日：2022-04-14
申请号：US17499454
申请日：2021-10-12
Applicant: Bio-Rad Europe GmbH , Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Ronald Lebofsky , Emilie Celine Claudie Macke , Rebecca Dievart , Christophe Quiring , Sophie Pierre
IPC: B01L3/00
Abstract: A system, method, and platform for target detection, the system including: a base substrate; a set of sample processing regions defined at a broad surface of the substrate, wherein each of the set of sample processing regions includes: a set of microwell subarrays arranged in a gradient between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions; and a cover substrate configured to mate with the base substrate in a coupled mode, the cover substrate comprising a network of venting channels aligned with the set of sample processing regions upon mating the base substrate with the cover substrate in the coupled mode, the network of venting channels providing gas exchange between the base substrate and an environment surrounding the microwell assembly. The invention(s) can be used for MPN assays.
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公开(公告)号：US11248227B2
公开(公告)日：2022-02-15
申请号：US16927690
申请日：2020-07-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6869 , C12Q1/6809
Abstract: Methods and compositions are provided for making and using uniquely tagged target nucleic acid molecules.
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Patent Agency Ranking
公开(公告)号：US11186862B2
公开(公告)日：2021-11-30
申请号：US16012610
申请日：2018-06-19
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti , George Karlin-Neumann
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C12Q1/6832 , C12Q1/682
Abstract: Improved multiple displacement amplification (MDA) reagents and methods are provided.
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公开(公告)号：US12162015B2
公开(公告)日：2024-12-10
申请号：US17499454
申请日：2021-10-12
Applicant: Bio-Rad Europe GmbH , Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Ronald Lebofsky , Emilie Celine Claudie Macke , Rebecca Dievart , Christophe Quiring , Sophie Pierre
IPC: B01L3/00
Abstract: A system, method, and platform for target detection, the system including: a base substrate; a set of sample processing regions defined at a broad surface of the substrate, wherein each of the set of sample processing regions includes: a set of microwell subarrays arranged in a gradient between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions; and a cover substrate configured to mate with the base substrate in a coupled mode, the cover substrate comprising a network of venting channels aligned with the set of sample processing regions upon mating the base substrate with the cover substrate in the coupled mode, the network of venting channels providing gas exchange between the base substrate and an environment surrounding the microwell assembly. The invention(s) can be used for MPN assays.
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公开(公告)号：US11725206B2
公开(公告)日：2023-08-15
申请号：US17102111
申请日：2020-11-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti
IPC: C12N15/10
CPC classification number: C12N15/1096 , C12N15/1065
Abstract: Methods and compositions are provided herein for preparing high-throughput cDNA sequencing libraries.
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公开(公告)号：US20220118442A1
公开(公告)日：2022-04-21
申请号：US17499529
申请日：2021-10-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kalyan Handique , Ronald Lebofsky
Abstract: The invention(s) cover systems and methods for target detection in a multiplexed and rapid manner. Embodiments of the system can include: a base substrate; and an array of sample processing regions defined at a broad surface of the base substrate, wherein each of the array of sample processing regions includes: a set of microwell subarrays arranged in a gradient by volumetric capacity between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions. The system can support methods, with example implementation by an automated platform, for returning preliminary results from a subset of microwells of the samples processing regions, as well as results pertaining to specific and non-specific amplification, for multiple targets of a sample.
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公开(公告)号：US20180340173A1
公开(公告)日：2018-11-29
申请号：US15984905
申请日：2018-05-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jeremy Agresti
IPC: C12N15/10 , C12Q1/6809
Abstract: Methods and compositions are provided for making and using uniquely tagged target nucleic acid molecules.
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