公开(公告)号：US20180291329A1

公开(公告)日：2018-10-11

申请号：US15577991

申请日：2016-05-27

Applicant: Biogen MA Inc.

Inventor： Justin Moretto ,  Thomas Matthews ,  Brandon Moore ,  Terrence Dobrowsky ,  An Zhang ,  John Smelko ,  Brandon Berry ,  Kelly Wiltberger

IPC: C12M1/34 ,  C12N5/00 ,  C07K16/06 ,  C12M1/36 ,  C12N5/073 ,  C12N5/071

Abstract: The present disclosure relates, in some aspects, to the field of process analytical technology with respect to biotherapeutic protein production processes and products.

公开(公告)号：US20220098556A1

公开(公告)日：2022-03-31

申请号：US17425618

申请日：2020-01-24

Applicant: Biogen MA Inc.

Inventor： Terrence Dobrowsky ,  Jenny Wangyuanzhen Shupe

IPC: C12N7/00 ,  C12M1/00

Abstract: Provided herein are methods of producing adeno-associated virus (AAV) comprising culturing AAV producer cell lines in a seed culture followed by an AAV production culture.