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公开(公告)号：US10563163B2
公开(公告)日：2020-02-18
申请号：US15322560
申请日：2015-07-02
Applicant: Biogen MA Inc.
Inventor： Brandon Berry , Justin Moretto
Abstract: Aspect of the disclosure relate to methods of assessing a bioreactor culture that involve determining a culture parameter of the manufacturing-scale bioreactor culture using a model that relates a Raman spectrum to the culture parameter. Related bioreactor system are also provided.
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公开(公告)号：US20210324321A9
公开(公告)日：2021-10-21
申请号：US16741044
申请日：2020-01-13
Applicant: Biogen MA Inc.
Inventor： Brandon Berry , Justin Moretto
Abstract: Aspect of the disclosure relate to methods of assessing a bioreactor culture that involve determining a culture parameter of the manufacturing-scale bioreactor culture using a model that relates a Raman spectrum to the culture parameter. Related bioreactor system are also provided.
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公开(公告)号：US20180291329A1
公开(公告)日：2018-10-11
申请号：US15577991
申请日：2016-05-27
Applicant: Biogen MA Inc.
Inventor： Justin Moretto , Thomas Matthews , Brandon Moore , Terrence Dobrowsky , An Zhang , John Smelko , Brandon Berry , Kelly Wiltberger
Abstract: The present disclosure relates, in some aspects, to the field of process analytical technology with respect to biotherapeutic protein production processes and products.
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Patent Agency Ranking
公开(公告)号：US20170130186A1
公开(公告)日：2017-05-11
申请号：US15322560
申请日：2015-07-02
Applicant: Biogen MA Inc.
Inventor： Brandon Berry , Justin Moretto
CPC classification number: C12M41/32 , C12M41/48 , G01N21/65 , G01N2201/12
Abstract: Aspect of the disclosure relate to methods of assessing a bioreactor culture that involve determining a culture parameter of the manufacturing-scale bioreactor culture using a model that relates a Raman spectrum to the culture parameter. Related bioreactor system are also provided.
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公开(公告)号：US11249026B2
公开(公告)日：2022-02-15
申请号：US14775255
申请日：2014-03-14
Applicant: Biogen MA Inc.
Inventor： Justin Moretto , Brandon Berry , Alex Doane
Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.
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公开(公告)号：US20170355947A9
公开(公告)日：2017-12-14
申请号：US15322560
申请日：2015-07-02
Applicant: Biogen MA Inc.
Inventor： Brandon Berry , Justin Moretto
CPC classification number: C12M41/32 , C12M41/48 , G01N21/65 , G01N2201/12
Abstract: Aspect of the disclosure relate to methods of assessing a bioreactor culture that involve determining a culture parameter of the manufacturing-scale bioreactor culture using a model that relates a Raman spectrum to the culture parameter. Related bioreactor system are also provided.
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7.发明授权Spectroscopic analysis of nutrient materials for use in a cell culture process 有权用于细胞培养过程的营养物质的光谱分析公开(公告)号：US09506867B2
公开(公告)日：2016-11-29
申请号：US14103801
申请日：2013-12-11
Applicant: Biogen MA Inc.
Inventor： Justin Moretto , Kelly Wiltberger
Abstract: In some embodiments, aspects of the disclosure relate to methods of evaluating cell culture materials, for example, nutrient materials, or other materials that can be used in cell culture media.
Abstract translation: 在一些实施方案中，本公开的方面涉及评估细胞培养物质，例如营养物质或可用于细胞培养基的其它材料的方法。
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公开(公告)号：US20160025633A1
公开(公告)日：2016-01-28
申请号：US14775255
申请日：2014-03-14
Applicant: BIOGEN MA INC.
Inventor： Justin Moretto , Brandon Berry , Alex Doane
IPC: G01N21/65
CPC classification number: G01N21/65 , G01J3/44 , G01N2201/0446 , G01N2201/06113
Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.
Abstract translation: 一方面，本公开提供了一种限定培养组分的拉曼特征的方法，所述方法包括：获得非干扰或最小干扰溶液中培养组分的拉曼光谱，鉴定拉曼光谱中的峰，其为 与培养组分相关，获得包含培养组分的培养基的拉曼光谱，并且除去与在培养物的拉曼光谱中鉴定的峰相比变形的培养基的拉曼光谱中的培养成分的峰 在非干扰或最小干扰的解决方案中的组件。
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