摘要:
A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.
摘要:
Catheters adapted to exchange heat with a body fluid flowing through a body conduit employ helical elongate lumens for heat transfer with the body fluid. The helical elongate lumen of a catheter forms multiple turns extending longitudinally of a portion of the catheter with the turns each being bonded to the catheter along a fraction of the length of the turn. The length of the lumen and its orientation in each turn has the lumen otherwise displaced over a major portion of its length from the elongate body. The turns of the helical lumen can be arranged in sets having different lengths to encounter all areas of the flow. One or more infusion lumens may also extend to an infusion port or ports. The helical elongate lumen is defined by an elongate, thin-walled element. This lumen is in fluid communication with a heater/chiller supplying a working fluid for heat transfer through the wall of the elongate element defining the helical elongate lumen. A proximal hub may be associated with the catheter to establish at least one suture anchor and to receive the heater/chiller flow through input and output lumens associated with the catheter and in fluid communication with the helical elongate lumens. The elongated lumens may also be arranged in non-helical arrangements such as in a semi-circular configuration, a figure-eight loop configuration or a random loop configuration.
摘要:
A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop iii which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.
摘要:
A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop iii which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.
摘要:
An indwelling heat exchange catheter with integrated temperature sensor includes a catheter tube. A closed loop heat exchanger extends from the catheter tube. A temperature sensor can be integrally formed with the catheter tube such that it is insulated from the closed loop heat exchanger. The indwelling heat exchange catheter can further include a guide-wire tube that extends from the catheter tube and in such a case, the temperature sensor can be affixed to the guide-wire tube. Alternatively, a wire can extend through the catheter tube and the temperature sensor can be affixed to the wire.
摘要:
A heat exchange catheter has a catheter body with a working fluid supply lumen extending therethrough, and terminating in a helical heat exchange tube that exits the body and extends proximally back along the catheter body. Working fluid flows through the heat exchange tube to exchange heat with the central venous system of a patient when the catheter body is properly placed in the patient.
摘要:
An intravenous catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongate body, a heat exchange element through which a heat exchange fluid circulates, and an inflation element or irregular surface positioned within the heat exchange element for promoting mixing of the circulating heat exchange fluid. The heat exchange element and inflation element preferably include inflatable balloons. The catheter preferably has two to four balloons having a substantially straight configuration, each balloon containing an inner balloon inflation element having a substantially spiral configuration. The catheter also preferably has at least one infusion lumen for providing access to the patient's blood and a guidewire lumen to accommodate a guidewire. The catheter is used in conjunction with a heat/cool system to cool a hyperthermic patient as quickly as possible, to warm a hypothermic patient as quickly as possible or to maintain normothermia.
摘要:
An indwelling heat exchange catheter with integrated temperature sensor includes a catheter tube. A closed loop heat exchanger extends from the catheter tube. A temperature sensor can be integrally formed with the catheter tube such that it is insulated from the closed loop heat exchanger. The indwelling heat exchange catheter can further include a guide-wire tube that extends from the catheter tube and in such a case, the temperature sensor can be affixed to the guide-wire tube. Alternatively, a wire can extend through the catheter tube and the temperature sensor can be affixed to the wire.
摘要:
A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
摘要:
The disclosed embodiments relate to systems and methods which match/allocate an incoming order to trade with “resting,” i.e. previously received but not yet matched, orders, recognizing that the algorithm or rules by which the incoming order is matched may affect the operation of the market for the financial product being traded. In particular, the disclosed embodiments relate to an adaptive match engine which draws upon different matching algorithms, e.g. the rules which dictate how a given order should be allocated among qualifying resting orders, depending upon market conditions, to improve the operation of the market. Thereby, by conditionally switching among matching algorithms within the same financial product, as will be described, the disclosed match engine automatically adapts to the changing market conditions of a financial product, e.g. a limited life product, in a non-preferential manner, maintaining fair order allocation while improving market liquidity, e.g., over the life of the product.