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公开(公告)号：US06589271B1
公开(公告)日：2003-07-08
申请号：US10015505
申请日：2001-12-13
申请人： Elbert Tzeng , Vaso Adzich , Hortensia Pompa , Scott M. Evans , Peter Barker , William J. Worthen , Suzanne C. Winter , David P. Balding , Kenneth A. Collins
发明人： Elbert Tzeng , Vaso Adzich , Hortensia Pompa , Scott M. Evans , Peter Barker , William J. Worthen , Suzanne C. Winter , David P. Balding , Kenneth A. Collins
IPC分类号： A61F700
CPC分类号： A61N1/39 , A61B2018/00011 , A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/126 , A61M1/369 , A61M5/44 , A61M25/1011 , A61N1/36017
摘要： Catheters adapted to exchange heat with a body fluid flowing through a body conduit employ helical elongate lumens for heat transfer with the body fluid. The helical elongate lumen of a catheter forms multiple turns extending longitudinally of a portion of the catheter with the turns each being bonded to the catheter along a fraction of the length of the turn. The length of the lumen and its orientation in each turn has the lumen otherwise displaced over a major portion of its length from the elongate body. The turns of the helical lumen can be arranged in sets having different lengths to encounter all areas of the flow. One or more infusion lumens may also extend to an infusion port or ports. The helical elongate lumen is defined by an elongate, thin-walled element. This lumen is in fluid communication with a heater/chiller supplying a working fluid for heat transfer through the wall of the elongate element defining the helical elongate lumen. A proximal hub may be associated with the catheter to establish at least one suture anchor and to receive the heater/chiller flow through input and output lumens associated with the catheter and in fluid communication with the helical elongate lumens. The elongated lumens may also be arranged in non-helical arrangements such as in a semi-circular configuration, a figure-eight loop configuration or a random loop configuration.
摘要翻译： 适于与流过身体导管的体液交换热量的导管采用螺旋形细长腔，用于与体液的热传递。 导管的螺旋细长内腔形成多个匝，导管沿导管的一部分纵向延伸，匝各自沿转弯长度的一部分与导管接合。 内腔的长度及其在每一个回合中的取向具有内腔，其长度方向与细长主体相距很大一部分。 螺旋腔的匝数可以以具有不同长度的组合排列以遇到流动的所有区域。 一个或多个输注腔也可以延伸到输注端口。 螺旋细长的内腔由细长的薄壁元件限定。 该内腔与加热器/冷却器流体连通，加热器/冷却器供应用于通过限定螺旋细长内腔的细长元件的壁进行热传递的工作流体。 近端毂可以与导管相关联，以建立至少一个缝线锚，并且通过与导管相关联并与螺旋细长腔流体连通的输入和输出腔来接收加热器/制冷机流。 细长的腔也可以以非螺旋布置的方式布置，例如半圆形配置，图八循环配置或随机环配置。
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2.发明授权公开(公告)号：US08128595B2
公开(公告)日：2012-03-06
申请号：US09939239
申请日：2001-08-24
CPC分类号： A61F7/12 , A61B2017/00084 , A61F7/123 , A61F2007/0054 , A61F2007/126 , A61M1/369 , A61M5/44 , A61M25/00 , A61M25/002 , A61M25/003 , A61M25/0032 , A61M25/02 , A61M25/10 , A61M25/1011 , A61M2025/0036 , A61M2025/1013 , A61M2205/36 , A61M2205/366
摘要： A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.
摘要翻译： 一套零件包括使用具有热交换元件的中心静脉导管的系统和用于控制患者体温的说明书。 中心静脉导管设置有一个或多个腔，用于提供对患者的中央血液供应的通路，以及用于将热交换流体传递到热交换元件的附加腔。 热交换流体温度通过反馈回路来控制，其中感测患者温度并用于控制包括与热交换流体热交换关系的加热装置和/或冷却装置的温度控制单元。 管组在中央静脉管路和温度控制单元之间输送热交换流体，其中泵用于将流体循环在系统中的封闭流体回路中。
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3.发明授权公开(公告)号：US06572640B1
公开(公告)日：2003-06-03
申请号：US09990211
申请日：2001-11-21
IPC分类号： A61F700
CPC分类号： A61F7/123 , A61F2007/0288 , A61F2007/126
摘要： A cardiopulmonary bypass patient is precooled using an indwelling catheter. Cardiopulmonary bypass is initiated when a target temperature or range are achieved, as determined by automatic temperature feedback provided to a control module. The patient may also be rewarmed at a controlled rate during or after termination of cardiopulmonary bypass such that faster and safer termination is realized.
摘要翻译： 心肺旁路患者使用留置导管进行预冷。 当通过提供给控制模块的自动温度反馈确定达到目标温度或范围时，启动心肺分流术。 患者也可能在体外循环终止期间或之后以受控的速度重温，从而实现更快更安全的终止。
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公开(公告)号：US07278984B2
公开(公告)日：2007-10-09
申请号：US10334414
申请日：2002-12-31
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F7/0085 , A61F2007/0054 , A61F2007/126
摘要： A patient control system uses a patient-implanted catheter in thermal communication with a fluid bath via a circulating fluid circuit. A controller automatically controls the temperature of the fluid bath as required for selectively cooling or heating the patient in accordance with patient temperature measurements. The controller thermally decouples the catheter and patient from the fluid bath during changes in fluid bath temperatures in order to overcome the effects of system thermal mass.
摘要翻译： 患者控制系统使用患者植入的导管与流体浴通过循环流体回路热连通。 根据患者的温度测量，控制器根据需要自动控制流体浴的温度以选择性地冷却或加热患者。 控制器在流体浴温度的变化期间使导管和患者与流体浴热分离，以克服系统热质量的影响。
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5.发明授权Catheter with multiple heating/cooling fibers employing fiber spreading features 有权具有采用纤维扩散特征的多个加热/冷却纤维的导管公开(公告)号：US06450990B1
公开(公告)日：2002-09-17
申请号：US09294080
申请日：1999-04-19
IPC分类号： A61F712
CPC分类号： A61F7/123 , A61B2018/00011 , A61F7/12 , A61F2007/0054 , A61F2007/126 , A61M1/369 , A61M5/44 , A61M25/00 , A61M25/0009 , A61M2205/36
摘要： A catheter using multiple hollow fibers to carry a heating/cooling fluid employs fiber spreading features to improve heat transfer and help prevent clotting of body fluids within which the catheter is immersed. The catheter includes a length of outer tube surrounding an inner tube. The inner tube conveys fluids in one direction, and the passageway between inner and outer tubes conveys fluids in the opposite direction. The inner and outer tubes have proximal distal ends. The distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing and optional reservoir, which cooperatively return fluid to the passageway between inner and outer tubes. In another embodiment, each fiber includes both outflowing and return lumens, enabling the fibers' distal ends to freely move about. In another embodiment, each fiber proceeds outward from the proximal fluid transfer housing, and returns back to form a loop. In each different embodiment, the invention includes one or more actuating structures to spread the fibers. The actuating structure may include, for example, fiber shaping, a retractable spreading member, elastic bias built into the fibers, etc.
摘要翻译： 使用多个中空纤维携带加热/冷却流体的导管使用纤维铺展特征来改善热传递并有助于防止导管浸入其中的体液的凝结。 导管包括围绕内管的一段长度的外管。 内管沿一个方向输送流体，内管和外管之间的通道沿相反方向输送流体。 内管和外管具有近端远端。 远端是封闭的，但是近端是敞开的，以允许将加热或冷却流体引入内管，并且将流体从内管和外管之间的通道中取出。 在管的远端存在耦合到多个中空热交换纤维的近端流体转移壳体。 这些纤维的远端可以通常连接到远端流体传送壳体和任选的储存器，其将流体协作地返回到内管和外管之间的通道。 在另一个实施例中，每个纤维包括流出和回流腔两者，使纤维的远端能够自由移动。 在另一个实施例中，每个纤维从近端流体转移壳体向外进入，并返回以形成环。 在每个不同的实施例中，本发明包括一个或多个驱动结构以扩展纤维。 致动结构可以包括例如纤维成型，可伸缩铺展件，内置在纤维中的弹性偏置等
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公开(公告)号：US06447474B1
公开(公告)日：2002-09-10
申请号：US09396200
申请日：1999-09-15
申请人： David P. Balding
发明人： David P. Balding
IPC分类号： A61M3100
CPC分类号： A61M25/00 , A61M2205/3368 , A61M2205/3606
摘要： A machine-driven automatic fever abatement system treats or prevents fever in hospital patients by administering medication, coolant, or other antipyretic means. The system includes a path, a flow device, a source of treatment substance, fever-characteristic sensors, and a controller. The path may be an open-ended structure, such as a tube, or a closed-ended structure such as a catheter with a sealed, internal path. The path is coupled to one or more bodily sites of the patient. The path is coupled to the flow device, which is itself attached to the source. The source contains a treatment substance such as medication (in the case of an open-ended path) or a coolant (in the case of a closed-ended path). One or more fever characteristic sensors are attached to various sites on the patient, for sensing temperature, metabolic rate, and/or other fever-affected physiological properties.
摘要翻译： 机器自动灭火系统通过给予药物，冷却剂或其他解热手段治疗或预防住院患者的发烧。 该系统包括路径，流动装置，处理物质源，发热特征传感器和控制器。 该路径可以是开放式结构，例如管，或封闭式结构，例如具有密封的内部路径的导管。 该路径耦合到患者的一个或多个身体部位。 该路径耦合到流动装置，该装置本身连接到源。 源包含诸如药物（在开放式路径的情况下）或冷却剂（在封闭路径的情况下）的处理物质。 一个或多个发热特征传感器连接到患者的各个部位，用于感测温度，代谢率和/或其他受发热影响的生理特性。
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公开(公告)号：US4731260A
公开(公告)日：1988-03-15
申请号：US683252
申请日：1984-12-18
申请人： David P. Balding , Li-Chien Hsu , Sun De Tong , Steven A. Craw
发明人： David P. Balding , Li-Chien Hsu , Sun De Tong , Steven A. Craw
IPC分类号： B01D37/02 , A61K35/14 , A61M1/16 , A61M1/18 , A61M1/22 , A61M1/36 , A61M5/165 , B01D39/16 , B01D67/00 , B01D13/04
CPC分类号： B01D67/0088 , A61M1/3627 , B01D39/1623
摘要： A filter material comprising hydrophobic filter media treated with a wetting agent which consists essentially of a material selected from the group consisting of polysobate 20, polysorbate 40, polysorbate 60 and polysorbate 80. The wetting agent is applied by dissolving it in a solvent and spraying the resulting solution onto the filter media.
摘要翻译： 一种过滤材料，其包括用润湿剂处理的疏水性过滤介质，该润湿剂基本上由选自聚羟基酯20，聚山梨醇酯40，聚山梨醇酯60和聚山梨醇酯80的材料组成。润湿剂通过将其溶解在溶剂中并喷涂 产生的溶液到过滤介质上。
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公开(公告)号：US4170421A
公开(公告)日：1979-10-09
申请号：US939627
申请日：1978-09-05
CPC分类号： A61L2/07
摘要： The invention provides an agitator system primarily for use in the production of liquids and semi-liquids which may be agitated during a sterilization process. A sealed chamber may be filled with live steam or a mixture of steam and air or water. Inside the chamber is a relatively simple table mount which enables a reciprocal motion of a product continuously during the entire or a part of the process. A suitable driving power source is positioned outside of the chamber and connected through the chamber wall to give a reciprocal motion to the table. The driving power source is adapted to accommodate any of a plurality of production variables such as changes in: length of stroke or amplitude of vibration, rate of stroke or frequency of vibration, rate of acceleration or deceleration, or the like.
摘要翻译： 本发明提供了主要用于生产在灭菌过程中可被搅动的液体和半液体的搅拌器系统。 密封的室可以填充有活蒸汽或蒸汽和空气或水的混合物。 在室内是相对简单的桌面安装件，其能够在整个或部分过程中连续地产生产品的往复运动。 合适的驱动动力源位于腔室的外部并通过腔室壁连接以给桌面提供往复运动。 驱动电源适于容纳多个生产变量中的任何一个，例如：行程长度或振动幅度，行程速率或振动频率，加速或减速率等的变化。
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公开(公告)号：US5417969A
公开(公告)日：1995-05-23
申请号：US154654
申请日：1993-11-18
申请人： Li-Chien Hsu , David P. Balding , Lawrence Farhat
发明人： Li-Chien Hsu , David P. Balding , Lawrence Farhat
CPC分类号： A61L33/0017 , A61L33/0011
摘要： Processes for forming a uniform, continuous coating of heparin covalently bonded to blood-contacting polyvinylchloride surfaces of a medical device are disclosed. These processes include coating the polyvinylchloride surfaces with an organic solvent solution of heparin complexed with an organic cation, and then exposing the coated surfaces to ionizing radiation to covalently bind the heparin moiety to the polyvinylchloride. The complex of the coating is formed from a heparin moiety and at least one cationic moiety selected from the group consisting of dimethylstearylamine, polyethyleneimine, benzalkonium, stearylkonium, and tridodecylmethylammonium; the complex is soluble in organic solvents and forms continuous and uniform coatings on polyvinylchloride. Advantageously, the heparin moiety can be bonded to the polyvinylchloride surfaces simultaneously with sterilizing the medical devices using ionizing radiation.
摘要翻译： 公开了用于形成均匀连续涂覆肝素的方法，其共价键合到医疗装置的与血液接触的聚氯乙烯表面。 这些方法包括用与有机阳离子络合的肝素的有机溶剂溶液涂覆聚氯乙烯表面，然后将涂覆的表面暴露于电离辐射以将肝素部分共价结合到聚氯乙烯上。 涂层的复合物由肝素部分和至少一种选自二甲基硬脂胺，聚乙烯亚胺，苯扎氯铵，硬脂基肟和十三烷基甲基铵的阳离子部分形成; 该复合物可溶于有机溶剂，并在聚氯乙烯上形成连续且均匀的涂层。 有利地，肝素部分可以在使用电离辐射对医疗装置进行消毒的同时与聚氯乙烯表面结合。
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10.发明授权
公开(公告)号：US4734269A
公开(公告)日：1988-03-29
申请号：US743693
申请日：1985-06-11
CPC分类号： A61M1/3627 , A61M1/3673 , Y10S128/03 , Y10S261/28
摘要： A liquid-gas bubble separator comrising a container having an inlet for a fluid which includes liquid and gas bubbles, an outlet and upstream and downstream vents. A filter element is provided in the container between the inlet and the outlet. The filter element permits the passage of the liquid and inhibits the passage of the gas bubbles. The filter element is between the upstream and downstream vents so that gas bubbles which do not pass through the filter element can be vented through the upstream vent, and any gas bubbles downstream of the filter element can be vented through the downstream vent. A bypass passage is provided around the filter element. A portion of the filtered fluid is recirculated through the bypass passage to prevent forward flow through the bypass passage when the filter element is clean, and such recirculating flow is terminated when the filter is clogged to a predetermined degree to thereby open the bypass passage for forward flow.
摘要翻译： 液体气泡分离器包括具有用于流体的入口的容器，该流体包括液体和气泡，出口以及上游和下游通风口。 过滤元件设置在入口和出口之间的容器中。 过滤元件允许液体通过并阻止气泡的通过。 过滤元件位于上游和下游通气口之间，使得不通过过滤元件的气泡可以通过上游通风口排放，并且过滤元件下游的任何气泡可以通过下游通风口排出。 旁路通道设置在过滤元件周围。 过滤流体的一部分通过旁路通道再循环，以防止过滤器元件清洁时向前流过旁路通道，并且当过滤器堵塞到预定的程度时这种再循环流程终止，从而打开旁路通道以进行向前 流。
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