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公开(公告)号：US11179457B2
公开(公告)日：2021-11-23
申请号：US16629525
申请日：2018-07-09
发明人： Arun V. Iyer , Abby Rae Patterson , Joseph Gilbert Victoria , Eric Martin Vaughn , Luis Alejandro Hernandez , Jennifer L. English
IPC分类号： A61K39/125 , A61P31/14 , C07K14/005 , C12N7/00 , C07K16/10 , G01N33/569 , A61K39/00
摘要： The present invention relates to killed/inactivated and/or recombinant Senecavirus A immunogenic compositions and vaccines, and methods of preventing or treating animals in need of with such an immunogenic compositions and vaccines.
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公开(公告)号：US11858963B2
公开(公告)日：2024-01-02
申请号：US17215636
申请日：2021-03-29
发明人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
IPC分类号： C07K14/005 , C12N7/00 , A61K39/12 , C12P21/02 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , C12P21/02 , A61K39/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N2710/14043 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2799/026
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
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公开(公告)号：US10767213B2
公开(公告)日：2020-09-08
申请号：US15456013
申请日：2017-03-10
发明人： Marc Allan Eichmeyer , Michael B. Roof , Merrill Lynn Schaeffer , Eric Martin Vaughn , Kun Yang , Jeremy Richard Rush , Daniel John Murfin
IPC分类号： C12Q1/37 , G01N33/569 , C07K7/06 , C07K14/00 , C07K7/08 , G01N33/68 , C07K14/005
摘要： The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled and unlabeled signature peptides, in particular wherein said viral proteins are antigens in a vaccine for porcine circovirus.
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公开(公告)号：US10702601B2
公开(公告)日：2020-07-07
申请号：US15920565
申请日：2018-03-14
发明人： Luis Alejandro Hernandez , Arun V. Iyer , Dianna M. Murphy Jordan , Abby Rae Patterson , Michael B. Roof , Eric Martin Vaughn , Joseph Gilbert Victoria
IPC分类号： A61K39/215 , C07K14/165 , C07K14/005 , C07K16/10 , A61K45/06 , C12N7/00 , A61K39/00
摘要： The present invention relates to immunogenic compositions, wherein the immunogenic compositions include a recombinant spike antigen porcine epidemic diarrhea virus (PEDV). The immunogenic compositions commonly include an oil-in-water emulsion as an adjuvant. Methods for producing the immunogenic compositions and the recombinant PEDV spike antigen are also provided.
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公开(公告)号：US10545148B2
公开(公告)日：2020-01-28
申请号：US16184018
申请日：2018-11-08
发明人： Arun V. Iyer , Joseph Ralph Hermann , Michael B. Roof , Eric Martin Vaughn , Merrill Lynn Schaeffer
IPC分类号： G01N33/569 , G01N33/68 , G01N33/50 , A61K39/12 , C12Q1/70 , C12P21/00 , A61K39/145 , C12N7/00 , C07K14/005 , A61K39/00
摘要： The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.
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公开(公告)号：US10961281B2
公开(公告)日：2021-03-30
申请号：US16154294
申请日：2018-10-08
发明人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
IPC分类号： C07K14/005 , A61K39/12 , C12P21/02 , C12N7/00 , A61K39/00
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
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公开(公告)号：US10555994B2
公开(公告)日：2020-02-11
申请号：US15562167
申请日：2016-03-29
IPC分类号： A61K39/12 , C07K14/005 , C12N15/62 , C07K1/14 , G01N33/53 , G01N33/566 , A61P31/20 , A61K39/00
摘要： The present invention relates to an immunogen-carrier, wherein the immunogen-carrier is preferably a virus-like particle (VLP) composed of a plurality of a modified PCV2 ORF2 protein. In particular, the present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a compliance marker for vaccines including a subunit antigen, and a DIVA (Differentiating Infected from Vaccinated Animals) system which makes it possible to differentiate between animals infected with a pathogen and animals treated with a subunit antigen derived from said pathogen.
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