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公开(公告)号：US11701419B2
公开(公告)日：2023-07-18
申请号：US16841485
申请日：2020-04-06
发明人： Arun Iyer , Luis Alejandro Hernandez , Abby Patterson , Bailey Arruda , Luis Gabriel Gimenez-Lirola , Dave Michael Anstrom , Eric M. Vaughn , Pablo E. Pineyro Pineiro , Troy James Kaiser , Joseph Ralph Hermann
CPC分类号： A61K39/12 , A61K39/23 , A61P31/20 , A61P37/04 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C12N2750/10034 , C12N2750/10071 , C12N2750/14034
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.
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公开(公告)号：US11896659B2
公开(公告)日：2024-02-13
申请号：US18058657
申请日：2022-11-23
发明人： Arun Iyer , Luis Alejandro Hernandez , Abby Patterson , Bailey Arruda , Luis Gabriel Gimenez-Lirola , Dave Michael Anstrom , Eric M. Vaughn , Pablo E Pineyro Pineiro , Troy James Kaiser , Joseph Ralph Hermann
CPC分类号： A61K39/12 , A61K39/23 , A61P31/20 , A61P37/04 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C12N2750/10034 , C12N2750/10071 , C12N2750/14034
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.
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公开(公告)号：US10555994B2
公开(公告)日：2020-02-11
申请号：US15562167
申请日：2016-03-29
IPC分类号： A61K39/12 , C07K14/005 , C12N15/62 , C07K1/14 , G01N33/53 , G01N33/566 , A61P31/20 , A61K39/00
摘要： The present invention relates to an immunogen-carrier, wherein the immunogen-carrier is preferably a virus-like particle (VLP) composed of a plurality of a modified PCV2 ORF2 protein. In particular, the present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a compliance marker for vaccines including a subunit antigen, and a DIVA (Differentiating Infected from Vaccinated Animals) system which makes it possible to differentiate between animals infected with a pathogen and animals treated with a subunit antigen derived from said pathogen.
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公开(公告)号：US11858963B2
公开(公告)日：2024-01-02
申请号：US17215636
申请日：2021-03-29
发明人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
IPC分类号： C07K14/005 , C12N7/00 , A61K39/12 , C12P21/02 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , C12P21/02 , A61K39/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N2710/14043 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2799/026
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
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公开(公告)号：US20210128712A1
公开(公告)日：2021-05-06
申请号：US16841485
申请日：2020-04-06
发明人： Arun IYER , Luis Alejandro Hernandez , Abby Patterson , Bailey Arruda , Luis Gabriel Gimenez-Lirola , Dave Michael Anstrom , Eric M. Vaughn
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.
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公开(公告)号：US10702601B2
公开(公告)日：2020-07-07
申请号：US15920565
申请日：2018-03-14
发明人： Luis Alejandro Hernandez , Arun V. Iyer , Dianna M. Murphy Jordan , Abby Rae Patterson , Michael B. Roof , Eric Martin Vaughn , Joseph Gilbert Victoria
IPC分类号： A61K39/215 , C07K14/165 , C07K14/005 , C07K16/10 , A61K45/06 , C12N7/00 , A61K39/00
摘要： The present invention relates to immunogenic compositions, wherein the immunogenic compositions include a recombinant spike antigen porcine epidemic diarrhea virus (PEDV). The immunogenic compositions commonly include an oil-in-water emulsion as an adjuvant. Methods for producing the immunogenic compositions and the recombinant PEDV spike antigen are also provided.
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公开(公告)号：US11179457B2
公开(公告)日：2021-11-23
申请号：US16629525
申请日：2018-07-09
发明人： Arun V. Iyer , Abby Rae Patterson , Joseph Gilbert Victoria , Eric Martin Vaughn , Luis Alejandro Hernandez , Jennifer L. English
IPC分类号： A61K39/125 , A61P31/14 , C07K14/005 , C12N7/00 , C07K16/10 , G01N33/569 , A61K39/00
摘要： The present invention relates to killed/inactivated and/or recombinant Senecavirus A immunogenic compositions and vaccines, and methods of preventing or treating animals in need of with such an immunogenic compositions and vaccines.
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公开(公告)号：US20230302113A1
公开(公告)日：2023-09-28
申请号：US18058657
申请日：2022-11-23
发明人： Arun IYER , Luis Alejandro Hernandez , Abby Patterson , Bailey Arruda , Luis Gabriel Gimenez-Lirola , Dave Michael Anstrom , Eric M. Vaughn , Pablo E Pineyro Pineiro , Troy James Kaiser , Joseph Ralph Hermann
CPC分类号： A61K39/12 , A61P37/04 , A61P31/20 , A61K39/23 , A61K2039/545
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 3 (PCV3) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV3 infection.
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公开(公告)号：US10961281B2
公开(公告)日：2021-03-30
申请号：US16154294
申请日：2018-10-08
发明人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
IPC分类号： C07K14/005 , A61K39/12 , C12P21/02 , C12N7/00 , A61K39/00
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
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