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公开(公告)号：US20190154688A1
公开(公告)日：2019-05-23
申请号：US16184018
申请日：2018-11-08
发明人： Arun V. Iyer , Joseph Ralph Hermann , Michael B. Roof , Eric Martin Vaughn , Merrill Lynn Schaeffer
IPC分类号： G01N33/569 , G01N33/68 , G01N33/50 , A61K39/12 , C12Q1/70 , C12P21/00 , A61K39/145 , C12N7/00 , C07K14/005
CPC分类号： G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C07K2319/21 , C07K2319/50 , C12N7/00 , C12N2710/14021 , C12N2710/14022 , C12N2710/14043 , C12N2710/14051 , C12N2710/14143 , C12N2750/10034 , C12N2750/10051 , C12N2760/16134 , C12N2760/16151 , C12N2760/20022 , C12N2760/20034 , C12N2760/20051 , C12P21/00 , C12Q1/701 , G01N33/5091 , G01N33/6854 , G01N2333/01
摘要： The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.
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公开(公告)号：US09879280B2
公开(公告)日：2018-01-30
申请号：US14649500
申请日：2013-12-06
IPC分类号： C07H21/04 , C12N5/00 , C12N7/00 , C12N15/00 , C12P21/06 , C12N15/86 , C07K14/005 , C12N15/85
CPC分类号： C12N15/86 , C07H21/04 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2502/00 , C12N2510/00 , C12N2710/14022 , C12N2710/14023 , C12N2710/14034 , C12N2710/14041 , C12N2710/14122 , C12N2710/14131 , C12N2710/14143 , C12N2710/20022 , C12N2710/20034 , C12N2710/20051 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2770/16022 , C12N2770/16034 , C12N2770/16051
摘要： The present invention may be included in the field of biotechnology and it covers the improved production of recombinant proteins in insect cells or insect larvae as biofactories by a novel expression cassette. This expression cassette comprises nucleic acid sequences such as promoters, homologous regions (hr) as enhancers, and sequences encoding transcriptional regulators, for example, the baculovirus Ac-ie-01 cDNA, or any combination thereof, which are able to increase the quality and production efficiency of the recombinant proteins. Moreover, the present invention is also directed to the vectors themselves comprising the above mentioned nucleic acid sequences of the invention, cells or insects infected, transformed or transfected with those sequences or vectors, and methods for producing the recombinant proteins by using the aforesaid sequences, vectors, cells or insects.
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公开(公告)号：US09669087B2
公开(公告)日：2017-06-06
申请号：US14661969
申请日：2015-03-18
发明人： Michael B Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel , Merrill Lynn Schaeffer
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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公开(公告)号：US20110280905A1
公开(公告)日：2011-11-17
申请号：US13049364
申请日：2011-03-16
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/552 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10062
摘要： The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).
摘要翻译： 本发明提供了一种新型嵌合猪圆环病毒感染性DNA克隆和活体减毒嵌合病毒，其中PCV2优选亚型PCV2b，衣壳基因整合到非致病性PCV1病毒基因组中。 在一个具体实施方案中，PCV2 capids基因是亚型PCV2b，其是在全世界猪中循环的主要亚型。 称为PCV1-2b的减毒嵌合病毒有效保护猪免受PCV2b挑战，可用作活疫苗以及灭活（灭杀）疫苗，可为PCV2b和PCV2a亚型感染提供保护和交叉保护。 本发明的活减毒疫苗也可有效地保护猪免于猪圆环病毒相关疾病（PCVAD）。
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5.发明授权Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 有权使用PCV2免疫原性组合物来减轻猪的临床症状公开(公告)号：US07968285B2
公开(公告)日：2011-06-28
申请号：US12136923
申请日：2008-06-11
申请人： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
发明人： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
IPC分类号： C12Q1/70
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。
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公开(公告)号：US20100221283A1
公开(公告)日：2010-09-02
申请号：US12618485
申请日：2009-11-13
申请人： ANDRÉ JESTIN , EMMANUEL ALBINA , PIERRE LE CANN , PHILIPPE BLANCHARD , EVELYNE HUTET , CLAIRE ARNAULD , CATHERINE TRUONG , DOMINIQUE MAHE , ROLAND CARIOLET , FRANCOIS MADEC
发明人： ANDRÉ JESTIN , EMMANUEL ALBINA , PIERRE LE CANN , PHILIPPE BLANCHARD , EVELYNE HUTET , CLAIRE ARNAULD , CATHERINE TRUONG , DOMINIQUE MAHE , ROLAND CARIOLET , FRANCOIS MADEC
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection is further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
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公开(公告)号：US20100215690A1
公开(公告)日：2010-08-26
申请号：US12636180
申请日：2009-12-11
申请人： André Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
发明人： André Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
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公开(公告)号：US20100189743A1
公开(公告)日：2010-07-29
申请号：US12718214
申请日：2010-03-05
申请人： André JESTIN , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
发明人： André JESTIN , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
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公开(公告)号：US20100189736A1
公开(公告)日：2010-07-29
申请号：US12718197
申请日：2010-03-05
申请人： André Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
发明人： André Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
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公开(公告)号：US20100189735A1
公开(公告)日：2010-07-29
申请号：US12718183
申请日：2010-03-05
申请人： André Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
发明人： André Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , François Madec
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
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