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公开(公告)号：US20190134183A1
公开(公告)日：2019-05-09
申请号：US16250654
申请日：2019-01-17
申请人： Boehringer Ingelheim Animal Health USA Inc. , GENVEC INC. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of Homela
发明人： Justin WIDENER , Leszlie Woodyard , Leonardo Siger , Douglas Brough , Damodar Ettyreddy , Jason Gall , Duncan McVey , Tom Burrage , Lauri Motes-Kreimeyer , Marc Fiorucci
摘要： The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
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公开(公告)号：US09833502B2
公开(公告)日：2017-12-05
申请号：US14441988
申请日：2013-11-12
申请人： GenVec, Inc.
发明人： Ping Chen , Duncan McVey , Douglas Brough , Joseph Bruder
IPC分类号： A61K39/015 , A61K39/00
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/53 , Y02A50/412
摘要： The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.
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公开(公告)号：US20150329834A1
公开(公告)日：2015-11-19
申请号：US14817910
申请日：2015-08-04
申请人： GenVec, Inc.
发明人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods.
摘要翻译： 本发明提供了在细胞中繁殖猴腺病毒的方法，包括人细胞，其包含从人腺病毒分离的一种或多种基因产物。 还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。 本发明还提供了通过这种繁殖方法获得的猴腺病毒，其包括复制缺陷型猴腺病毒。
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公开(公告)号：US10188721B2
公开(公告)日：2019-01-29
申请号：US15419418
申请日：2017-01-30
申请人： MERIAL INC. , GENVEC INC. , THE UNITED STATES OF AMERICA, as represented by the Secretary of Homeland Security
发明人： Justin Widener , Leszlie Woodyard , Leonardo Siger , Douglas Brough , Damodar Ettyreddy , Jason Gall , Duncan McVey , Tom Burrage , Lauri Motes-Kreimeyer , Marc Fiorucci
IPC分类号： A61K39/135 , C07K14/005 , C12N7/00 , A61K39/12 , C12N15/86 , A61K39/00
摘要： The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
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公开(公告)号：US20170216422A1
公开(公告)日：2017-08-03
申请号：US15419418
申请日：2017-01-30
申请人： MERIAL INC. , GENVEC INC. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary of Homeland Security
发明人： Justin Widener , Leszlie Woodyward , Leonardo Siger , Douglas Brough , Damodar Ettyreddy , Jason Gall , Duncan McVey , Tom Burrage
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2710/10034 , C12N2770/32134 , C12N2800/107
摘要： The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
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公开(公告)号：US09586998B2
公开(公告)日：2017-03-07
申请号：US14817910
申请日：2015-08-04
申请人： GenVec, Inc.
发明人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
IPC分类号： C07K14/005 , C12N15/86 , C12N7/00
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods.
摘要翻译： 本发明提供了在细胞中繁殖猴腺病毒的方法，包括人细胞，其包含从人腺病毒分离的一种或多种基因产物。 还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。 本发明还提供了通过这种繁殖方法获得的猴腺病毒，其包括复制缺陷型猴腺病毒。
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公开(公告)号：US20150297699A1
公开(公告)日：2015-10-22
申请号：US14441988
申请日：2013-11-12
申请人： GENVEC, INC.
发明人： Ping Chen , Duncan McVey , Douglas Brough , Joseph Bruder
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/53 , Y02A50/412
摘要： The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.
摘要翻译： 本发明涉及包含一种或多种多肽或一种或多种可诱导针对感染人的疟原虫物种的保护性免疫应答的核酸序列的组合物。 本发明还涉及使用这样的组合物来诱导针对哺乳动物的疟原虫寄生虫的保护性免疫应答的方法。
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