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8 条记录 (耗时 0.021 秒)

    Synthesis of pyrrole-2-carbonitriles
    1.
    发明申请
    Synthesis of pyrrole-2-carbonitriles 失效
    吡咯-2-碳腈的合成

    公开(公告)号：US20050222432A1

    公开(公告)日：2005-10-06

    申请号：US11086061

    申请日：2005-03-22

    申请人： Jean Helom ,  Arkadiy Rubezhov ,  Anthony Pilcher ,  Bogdan Wilk

    发明人： Jean Helom ,  Arkadiy Rubezhov ,  Anthony Pilcher ,  Bogdan Wilk

    IPC分类号： C07B43/08 ,  C07D207/34 ,  C07D207/30

    CPC分类号： C07D207/34

    摘要： The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.

    摘要翻译： 本发明涉及吡咯-2-碳腈如1-甲基吡咯-2-腈的制备方法。 这样的方法优选包括在溶剂存在下使吡咯与氯磺酰基异氰酸酯反应并使所得产物与摩尔过量的酰胺如N，N-二甲基甲酰胺接触的步骤。 然后将该接触步骤的产物与摩尔过量的有机碱接触以产生沉淀物和溶液相。 然后将沉淀物与溶液相分离，并从所得溶液相中分离相应的吡咯-2-腈。

    Process for preparation of substituted amino alcohols
    8.
    发明申请
    Process for preparation of substituted amino alcohols 失效
    取代氨基醇的制备方法

    公开(公告)号：US20050124806A1

    公开(公告)日：2005-06-09

    申请号：US11006936

    申请日：2004-12-08

    申请人： Yanzhong Wu ,  Arkadiy Rubezhov ,  Jean Schmid ,  Jay Afragola

    发明人： Yanzhong Wu ,  Arkadiy Rubezhov ,  Jean Schmid ,  Jay Afragola

    IPC分类号： C07C213/02 ,  C07C213/04 ,  C07C215/08 ,  C07D487/04 ,  C07D265/30 ,  C07D207/46 ,  C07D211/20

    CPC分类号： C07D487/04 ,  C07C213/02 ,  C07C215/08

    摘要： There is provided a process for the preparation of substituted amino alcohols HO—(CH2)n—NR1R2 from haloalcohols HO—(CH2)n—X, where X is Cl, Br or I, by reaction with an amine HNR1R2, in water as solvent at a temperature range of about 20° C. to about 90° C. optionally in the presence of a catalytic amount of an iodide source metal iodides. The haloalcohols are useful in the preparation of 6-[(substituted)phenyl]-triazolopyrimidine compounds which are useful in the treatment of cancer.

    摘要翻译： 提供了用于制备取代的氨基醇HO-（CH 2）n - NR 1 - ， - O 2的方法， 其中X是Cl，Br或I，通过与胺HNR 1反应而得到的卤代醇HO-（CH 2）n -X 在约20℃至约90℃的温度范围内的水溶液中，任选地在催化量的碘化物源金属碘化物的存在下进行。 卤代醇可用于制备可用于治疗癌症的6 - [（取代的）苯基] - 三唑并嘧啶化合物。