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公开(公告)号：US20180282381A1
公开(公告)日：2018-10-04
申请号：US15920331
申请日：2018-03-13
申请人： Bolt Threads, Inc.
IPC分类号： C07K14/435 , C07K14/395
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to at least 2 distinct secretion signals.
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公开(公告)号：US20240150416A1
公开(公告)日：2024-05-09
申请号：US18341669
申请日：2023-06-26
申请人： BOLT THREADS, INC.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C07K14/435 , C07K14/395 , C12P21/02
CPC分类号： C07K14/43586 , C07K14/395 , C12P21/02 , C07K2319/02
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the α-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US20180282380A1
公开(公告)日：2018-10-04
申请号：US15920291
申请日：2018-03-13
申请人： Bolt Threads, Inc.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C07K14/435 , C07K14/395
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the α-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US20220306706A1
公开(公告)日：2022-09-29
申请号：US17751277
申请日：2022-05-23
申请人： BOLT THREADS, INC.
IPC分类号： C07K14/435 , C07K14/395 , C12N15/81 , C12P21/02 , C12N15/62
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to at least 2 distinct secretion signals.
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公开(公告)号：US20210230235A1
公开(公告)日：2021-07-29
申请号：US17138350
申请日：2020-12-30
申请人： Bolt Threads, Inc.
IPC分类号： C07K14/435 , C07K14/395 , C12N15/81 , C12P21/02
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to at least 2 distinct secretion signals.
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公开(公告)号：US12122810B2
公开(公告)日：2024-10-22
申请号：US17751277
申请日：2022-05-23
申请人： BOLT THREADS, INC.
IPC分类号： C07K14/435 , C07K14/395 , C12N1/19 , C12N15/62 , C12N15/81 , C12P21/02
CPC分类号： C07K14/43586 , C07K14/395 , C12N15/625 , C12N15/815 , C12P21/02 , C07K2319/02 , C07K2319/036
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to at least 2 distinct secretion signals.
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公开(公告)号：US20220315630A1
公开(公告)日：2022-10-06
申请号：US17695219
申请日：2022-03-15
申请人： Bolt Threads, Inc.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C07K14/435 , C07K14/395 , C12P21/02
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the a-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US10906947B2
公开(公告)日：2021-02-02
申请号：US15920331
申请日：2018-03-13
申请人： Bolt Threads, Inc.
IPC分类号： C12N1/15 , C12N15/81 , C12P21/02 , C07K14/46 , C07K19/00 , C07K14/435 , C07K14/395
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to at least 2 distinct secretion signals.
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公开(公告)号：US11725030B2
公开(公告)日：2023-08-15
申请号：US17695219
申请日：2022-03-15
申请人： Bolt Threads, Inc.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C07K14/435 , C07K14/395 , C12P21/02
CPC分类号： C07K14/43586 , C07K14/395 , C12P21/02 , C07K2319/02
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the α-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US11370815B2
公开(公告)日：2022-06-28
申请号：US17138350
申请日：2020-12-30
申请人： Bolt Threads, Inc.
IPC分类号： C07K14/435 , C07K14/395 , C12N15/81 , C12P21/02 , C12N15/62 , C12N1/19
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to at least 2 distinct secretion signals.
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