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公开(公告)号：US20190330287A1
公开(公告)日：2019-10-31
申请号：US16477133
申请日：2018-01-16
申请人： Bolt Threads, Inc.
IPC分类号： C07K14/435 , C12P21/02
摘要： This invention relates to elastomeric protein and elastomeric protein production. In particular, the invention is directed to elastomeric protein sequences, including methods and compositions for production of elastomeric protein sequences, such as expression constructs, and host cells, and including compositions generated from the elastomeric protein sequences.
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公开(公告)号：US20180273693A1
公开(公告)日：2018-09-27
申请号：US15945673
申请日：2018-04-04
申请人： Bolt Threads, Inc.
CPC分类号： C08H1/00 , B29C48/022 , B29C48/919 , B29K2089/00 , B29K2995/0077 , B29L2031/731 , C07K14/43518 , C07K14/43586 , C07K2319/02 , C07K2319/43 , C12P21/00 , C12P21/02 , D01D1/02 , D01D5/00 , D01F4/00 , D01F4/02 , D01F6/68 , D01F11/02
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US09963554B2
公开(公告)日：2018-05-08
申请号：US15073514
申请日：2016-03-17
申请人： Bolt Threads, Inc.
CPC分类号： C08H1/00 , B29C47/0004 , B29C47/8895 , B29K2089/00 , B29K2995/0077 , B29L2031/731 , C07K14/43518 , C07K14/43586 , C07K2319/02 , C07K2319/43 , C12P21/00 , C12P21/02 , D01D1/02 , D01D5/00 , D01F4/00 , D01F4/02 , D01F6/68 , D01F11/02
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US11725030B2
公开(公告)日：2023-08-15
申请号：US17695219
申请日：2022-03-15
申请人： Bolt Threads, Inc.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C07K14/435 , C07K14/395 , C12P21/02
CPC分类号： C07K14/43586 , C07K14/395 , C12P21/02 , C07K2319/02
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the α-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US11306127B2
公开(公告)日：2022-04-19
申请号：US15920291
申请日：2018-03-13
申请人： Bolt Threads, Inc.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C12P21/02 , C07K14/395 , C07K14/435
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the α-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US10988515B2
公开(公告)日：2021-04-27
申请号：US16477133
申请日：2018-01-16
申请人： Bolt Threads, Inc.
IPC分类号： C07K14/435 , C12P21/02
摘要： This invention relates to elastomeric protein and elastomeric protein production. In particular, the invention is directed to elastomeric protein sequences, including methods and compositions for production of elastomeric protein sequences, such as expression constructs, and host cells, and including compositions generated from the elastomeric protein sequences.
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公开(公告)号：US20180298151A1
公开(公告)日：2018-10-18
申请号：US16016483
申请日：2018-06-22
申请人： Bolt Threads, Inc.
IPC分类号： C08H1/00 , D01F11/02 , B29C47/00 , D01F4/02 , D01F4/00 , D01D5/00 , D01D1/02 , C12P21/02 , C12P21/00 , D01F6/68 , B29C47/88 , C07K14/435 , B29L31/00
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US20230192965A1
公开(公告)日：2023-06-22
申请号：US18045214
申请日：2022-10-10
申请人： BOLT THREADS, INC.
IPC分类号： C08H1/00 , B29C48/00 , B29C48/88 , C12P21/02 , D01F4/00 , D01F4/02 , D01F6/68 , C07K14/435 , C12P21/00 , D01D1/02 , D01D5/00 , D01F11/02
CPC分类号： C08H1/00 , B29C48/022 , B29C48/919 , C07K14/43518 , C07K14/43586 , C12P21/00 , C12P21/02 , D01D1/02 , D01D5/00 , D01F4/00 , D01F4/02 , D01F6/68 , D01F11/02 , B29K2089/00 , B29K2995/0077 , B29L2031/731 , C07K2319/02
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US20220315630A1
公开(公告)日：2022-10-06
申请号：US17695219
申请日：2022-03-15
申请人： Bolt Threads, Inc.
发明人： Joshua Kittleson , Thomas Stevens , Rena Hill , Carlos Gustavo Pesce , David N. Breslauer , Daniel M. Widmaier
IPC分类号： C07K14/435 , C07K14/395 , C12P21/02
摘要： The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the a-mating factor (αMF) of Saccharomyces cerevisiae and a non-αMF signal peptide.
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公开(公告)号：US10435516B2
公开(公告)日：2019-10-08
申请号：US15945673
申请日：2018-04-04
申请人： Bolt Threads, Inc.
IPC分类号： C08H1/00 , C12N15/80 , C12N15/74 , B29C48/00 , B29C48/88 , C12P21/02 , D01F4/00 , D01F4/02 , D01F6/68 , C07K14/435 , C12P21/00 , D01D1/02 , D01D5/00 , D01F11/02 , B29L31/00
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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