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公开(公告)号：US20240293667A1
公开(公告)日：2024-09-05
申请号：US18656175
申请日：2024-05-06
CPC分类号： A61N1/0551 , A61N1/3604 , A61N1/36062 , A61N1/36071 , A61N1/36125 , A61N1/36178 , A61N1/37217 , A61N1/36153 , A61N1/36157
摘要： An implantable pulse generator (IPG) is disclosed having a plurality of electrode nodes, each electrode node configured to be coupled to an electrode to provide stimulation pulses to a patient's tissue. The IPG includes a digital-to-analog converter configured to amplify a reference current to a first current specified by first control signals; a first resistance configured to receive the first current, wherein a voltage across the first resistance is held to a reference voltage at a first node; a plurality of branches each comprising a second resistance and configured to produce a branch current, wherein a voltage across each second resistance is held to the reference voltage at second nodes; and a switch matrix configurable to selectively couple any branch current to any of the electrode nodes via the second nodes.
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公开(公告)号：US11724114B2
公开(公告)日：2023-08-15
申请号：US17020369
申请日：2020-09-14
发明人： Pujitha Weerakoon , David M. Wagenbach , Philip L. Weiss , Goran N. Marnfeldt , Kiran K. Gururaj
CPC分类号： A61N1/3758 , A61N1/36062 , A61N1/025 , A61N1/0534 , A61N1/378
摘要： An implantable pulse generator (IPG) is disclosed having an improved ability to steer anodic and cathodic currents between the IPG's electrodes. Each electrode node has at least one PDAC/NDAC pair to source/sink or sink/source a stimulation current to an associated electrode node. Each PDAC and NDAC receives a current with a magnitude indicative of a total anodic and cathodic current, and data indicative of a percentage of that total that each PDAC and NDAC will produce in the patient's tissue at any given time, which activates a number of branches in each PDAC or NDAC. Each PDAC and NDAC may also receive one or more resolution control signals specifying an increment by which the stimulation current may be adjusted at each electrode. The current received by each PDAC and NDAC is generated by a master DAC, and is preferably distributed to the PDACs and NDACs by distribution circuitry.
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公开(公告)号：US20230201576A1
公开(公告)日：2023-06-29
申请号：US18171594
申请日：2023-02-20
CPC分类号： A61N1/0551 , A61N1/36125 , A61N1/36062 , A61N1/3604 , A61N1/36071 , A61N1/36178 , A61N1/37217 , A61N1/36153 , A61N1/36157
摘要： An implantable pulse generator (IPG) is disclosed having a plurality of electrode nodes, each electrode node configured to be coupled to an electrode to provide stimulation pulses to a patient's tissue. The IPG includes a digital-to-analog converter configured to amplify a reference current to a first current specified by first control signals; a first resistance configured to receive the first current, wherein a voltage across the first resistance is held to a reference voltage at a first node; a plurality of branches each comprising a second resistance and configured to produce a branch current, wherein a voltage across each second resistance is held to the reference voltage at second nodes; and a switch matrix configurable to selectively couple any branch current to any of the electrode nodes via the second nodes.
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4.发明授权公开(公告)号：US11565117B2
公开(公告)日：2023-01-31
申请号：US16864308
申请日：2020-05-01
IPC分类号： A61N1/36
摘要： Improved stimulation circuitry for controlling the stimulation delivered by an implantable stimulator is disclosed. The stimulation circuitry includes memory circuitry that stores pulse programs that define pulse shapes, steering programs that define electrode configurations, and aggregate programs that link a selected pulse program with a selected steering program. The aggregate programs also include an amplitude modulation factor that modulates the amplitude defined by the pulse program. The inclusion of an amplitude modulation factor in the aggregate program allows complex amplitude-modulated waveforms to be produced. Pulse definition circuits in the stimulation circuitry execute aggregate programs to generate stimulation waveforms, which stimulation waveforms can be generated simultaneously by the different pulse definition circuits.
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5.发明申请公开(公告)号：US20200346019A1
公开(公告)日：2020-11-05
申请号：US16864308
申请日：2020-05-01
IPC分类号： A61N1/36
摘要： Improved stimulation circuitry for controlling the stimulation delivered by an implantable stimulator is disclosed. The stimulation circuitry includes memory circuitry that stores pulse programs that define pulse shapes, steering programs that define electrode configurations, and aggregate programs that link a selected pulse program with a selected steering program. The aggregate programs also include an amplitude modulation factor that modulates the amplitude defined by the pulse program. The inclusion of an amplitude modulation factor in the aggregate program allows complex amplitude-modulated waveforms to be produced. Pulse definition circuits in the stimulation circuitry execute aggregate programs to generate stimulation waveforms, which stimulation waveforms can be generated simultaneously by the different pulse definition circuits.
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公开(公告)号：US10786665B2
公开(公告)日：2020-09-29
申请号：US15695984
申请日：2017-09-05
发明人： Goran N. Marnfeldt , Philip L. Weiss , Pujitha Weerakoon , David M. Wagenbach , Emanuel Feldman , Kiran K. Gururaj
摘要： Digital-to-analog converter (DAC) circuitry for providing currents at electrodes of an Implantable Pulse Generator (IPG) is disclosed. The DAC circuitry includes at least one PDAC for sourcing current to the electrodes, and at least one NDAC for sinking current from the electrodes. The PDACs are powered with power supplies VH (the compliance voltage) and Vssh in a high power domain, and the NDACs are powered with power supplies Vcc and ground in a low power domain. VH may change during IPG operation, and Vssh preferably also changes with a fixed difference with respect to VH. Digital control signals to the PDACs are formed (and possibly converted into) the high power domain, and transistors used to build the PDACs are biased in the high power domain, and thus may also change with VH. This permits transistors in the PDACs and NDACs to be made from normal low-voltage logic transistors.
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7.发明公开公开(公告)号：US20240359016A1
公开(公告)日：2024-10-31
申请号：US18663527
申请日：2024-05-14
发明人： Rosana Esteller , Goran N. Marnfeldt , Natalie A. Brill , David M. Wagenbach , Pujitha Weerakoon , Jordi Parramon
CPC分类号： A61N1/36139 , A61N1/0553 , A61N1/36062 , A61N1/36171 , A61N1/36175 , A61N1/36185 , A61N1/37241
摘要： An Implantable Pulse Generator (IPG) or External Trial Stimulator (ETS) system is disclosed that is capable of sensing an Evoked Compound Action Potential (ECAP), and (perhaps in conjunction with an external device) is capable of adjusting a stimulation program while keeping a location of a Central Point of Stimulation (CPS) constant. Specifically, one or more features of measured ECAP(s) indicative of its shape and size are determined, and compared to thresholds or ranges to modify the electrode configuration of the stimulation program.
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8.发明公开公开(公告)号：US20230218217A1
公开(公告)日：2023-07-13
申请号：US18185222
申请日：2023-03-16
CPC分类号： A61N1/36125 , A61N1/05 , A61N1/08
摘要： Sense amplifier circuits particularly useful in sensing neural responses in an Implantable Pulse Generator (IPG) are disclosed. The IPG includes a plurality of electrodes, with one selected as a sensing electrode and another selected as a reference to differentially sense the neural response in a manner that subtracts a common mode voltage (e.g., stimulation artifact) from the measurement. The circuits include a differential amplifier which receives the selected electrodes at its inputs, and comparator circuitries to assess each differential amplifier input to determine whether it is of a magnitude that is consistent with the differential amplifier's input requirements. Based on these determinations, an enable signal is generated which informs whether the output of the differential amplifier validly provides the neural response at any point in time. Further, clamping circuits are connected to the differential amplifier inputs to clamp these inputs in magnitude to prevent the differential amplifier from damage.
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公开(公告)号：US20230102847A1
公开(公告)日：2023-03-30
申请号：US17932764
申请日：2022-09-16
IPC分类号： A61N1/36
摘要： Methods and circuitry for calibrating stimulation circuitry in an implantable stimulator device (ISD) is disclosed. The ISD can sense neural response to the stimulation, and use an algorithm to assess those responses and determine a therapeutic window for a particular stimulation parameter, such as amplitude. Stimulation circuitry in the ISD is programmed with information indicative of the determined therapeutic window, such as by programming a minimum and/or maximum current amplitude. As well as restricting operation of the stimulation circuitry to within the therapeutic amplitude window, such programming calibrates the stimulation circuitry and allows an expanded range of, or all of, amplitude values supported by the stimulation circuitry to be used, which allows the amplitude to be incremented in smaller current increments.
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10.发明授权公开(公告)号：US11129987B2
公开(公告)日：2021-09-28
申请号：US16135961
申请日：2018-09-19
发明人： Rosana Esteller , Goran N. Marnfeldt , Natalie A. Brill , David M. Wagenbach , Pujitha Weerakoon , Jordi Parramon
摘要： An Implantable Pulse Generator (IPG) or External Trial Stimulator (ETS) system is disclosed that is capable of sensing an Evoked Compound Action Potential (ECAP), and (perhaps in conjunction with an external device) is capable of adjusting a stimulation program while keeping a location of a Central Point of Stimulation (CPS) constant. Specifically, one or more features of measured ECAP(s) indicative of its shape and size are determined, and compared to thresholds or ranges to modify the electrode configuration of the stimulation program.
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