公开(公告)号：US20220204655A1

公开(公告)日：2022-06-30

申请号：US17556408

申请日：2021-12-20

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein Kolste ,  Tatyana Dyndikova

IPC: C08B37/08 ,  A61K49/04

Abstract: The present disclosure pertains to iodinated polysaccharide compounds that comprise a polysaccharide backbone that comprises a plurality of carboxyl groups and a plurality of iodinated side groups. The present disclosure also pertains iodinated polysaccharide compounds in which at least a portion of carboxyl groups that are present in a carboxyl-containing polysaccharide chain are functionalized with a plurality of iodinated side groups. Other aspects of the present disclosure pertain to methods of forming iodinated polysaccharide compounds, medical compositions comprising iodinated polysaccharide compounds, medical procedures comprising introducing such medical compositions into or between tissue of a patient, and medical kits that comprise such medical compositions.

公开(公告)号：US20230127824A1

公开(公告)日：2023-04-27

申请号：US17972007

申请日：2022-10-24

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein Kolste ,  Tatyana Dyndikova ,  Yen-Hao Hsu

IPC: A61K49/04 ,  A61M5/19 ,  A61M5/00

Abstract: In some embodiments, the present disclosure pertains to systems for forming a hydrogel that comprise (a) a first composition that comprises a polyiodinated polyamino compound and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to medical hydrogels that are formed by reacting a polyiodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to methods of making polyiodinated polyamino compounds.