-
公开(公告)号：US20250017956A1
公开(公告)日：2025-01-16
申请号：US18762216
申请日：2024-07-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR. , Rick Dorn , Cristian Parisi , Niraj Gurung , Claire Hobbs
IPC: A61K31/765 , A61K45/06 , C08J3/075 , C08K3/011
Abstract: Disclosed herein are radiopaque, reactive multi-arm polymers that comprise an iodine-containing core region, a plurality of polymer arms comprising a plurality of polymer segments linked to the iodine-containing core region, and a plurality of reactive moieties linked to the plurality of polymer segments. Also disclosed are methods of forming such radiopaque, reactive multi-arm polymers, systems for forming hydrogel compositions that comprise (a) such radiopaque, reactive multi-arm polymers and (b) multifunctional crosslinking compounds comprising a plurality of complementary reactive moieties that are reactive with the reactive moieties of the radiopaque, reactive multi-arm polymers, as well as reaction products of such systems and methods of treatment using such systems.
-
公开(公告)号：US20250000954A1
公开(公告)日：2025-01-02
申请号：US18754776
申请日：2024-06-26
Applicant: Boston Scientific Scimed, Inc.
Inventor： Heather Cirka , Yen-Hao Hsu , Marc Plourde , Joseph Thomas Delaney, JR. , Cristian Parisi
Abstract: Systems for hydrogel hydrolysis as well as methods for hydrogel hydrolysis are disclosed. An example system may include a syringe barrel having a needle connector disposed thereon. A hydrogel hydrolysis material may be disposed in the syringe barrel. The hydrogel hydrolysis material may be configured to be injected into a hydrogel formed in the body of a patient in order to accelerate the hydrolysis of the hydrogel.
-
公开(公告)号：US20240293572A1
公开(公告)日：2024-09-05
申请号：US18590582
申请日：2024-02-28
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Cristian Parisi , Joseph Thomas Delaney, JR.
CPC classification number: A61K47/6903 , A61K47/61 , A61K47/64
Abstract: In some aspects, the present disclosure provides therapeutic-agent-releasing polyamino compounds that comprise a polyamino moiety that is covalently linked to a residue of a hydroxyl-substituted therapeutic agent by an ester bond. In various embodiments, such therapeutic-agent-releasing polyamino compounds are used to form therapeutic-agent-releasing hydrogels. In other aspects, the present disclosure provides therapeutic-agent-releasing polysaccharides that comprise a plurality of hydroxyl-substituted therapeutic agent residues that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide.
-
公开(公告)号：US20250128220A1
公开(公告)日：2025-04-24
申请号：US18918996
申请日：2024-10-17
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Heather Cirka , Marc Plourde , Alexis Compton , Anthony Hannan
IPC: B01F35/71 , A61K9/00 , A61K47/10 , A61K47/18 , A61L27/02 , A61L27/18 , A61L27/52 , B01F21/00 , B01F21/20 , B01F23/40 , B01F23/451 , B01F31/65 , B01F101/00
Abstract: In some aspects, the present disclosure pertains to systems for forming hydrogel compositions, the systems comprising a first reservoir containing an iodinated polymer composition that comprise an iodinated polymer having multiple cyclic imide ester groups, a second reservoir containing a buffered diluent solution having a first pH that comprises water, a first buffering agent and a polyamine compound, and a third reservoir containing a buffered accelerant solution having a second pH that is higher than the first pH and comprises water and a second buffering agent. Other aspects of the present disclosure pertain to methods of using such systems for forming hydrogel compositions.
-
公开(公告)号：US20250049964A1
公开(公告)日：2025-02-13
申请号：US18796777
申请日：2024-08-07
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Nicolas Ball-Jones , Sasha Viola Rios , Joseph Thomas Delaney, JR. , Cristian Parisi
IPC: A61K49/04
Abstract: In some aspects, the present disclosure pertains to an injectable hydrogel that comprises (a) one or more types of polymeric hydrogen bond donors, (b) one or more types of polymeric hydrogen bond acceptors and (c) water. Other aspects of the present disclosure pertain to kits that comprise a delivery device and one or more containers that contain an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water. Further aspects of the present disclosure pertain to medical procedures that comprise administering to a subject an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water.
-
Patent Agency Ranking
公开(公告)号：US20240390527A1
公开(公告)日：2024-11-28
申请号：US18670474
申请日：2024-05-21
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Sasha Viola Rios , Nicolas Ball-Jones , Joseph Thomas Delaney, JR. , Cristian Parisi
IPC: A61K49/04
Abstract: In some aspects the present disclosure provides a radiopaque, reactive copolymer comprising at least one hydrophilic polymer segment having a plurality of hydrophilic polymer segment ends, a plurality of iodinated polymer segments covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated polymer segments. In other aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, as well as to a crosslinked reaction product of the same. In further aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, under conditions such that the nucleophilic compound and the radiopaque, reactive copolymer crosslink after administration.
-
公开(公告)号：US20240301179A1
公开(公告)日：2024-09-12
申请号：US18591870
申请日：2024-02-29
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Cristian Parisi , Joseph Thomas Delaney, JR.
IPC: C08L5/08 , A61K9/06 , A61K47/36 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/58 , C08J3/075
CPC classification number: C08L5/08 , A61K9/06 , A61K47/36 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/58 , C08J3/075 , C08J2305/08 , C08L2201/06 , C08L2203/02 , C08L2312/00
Abstract: In some aspects, the present disclosure pertains to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In other aspects, the present disclosure pertains to systems for forming a hydrogel composition that comprise (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In further aspects, the present disclosure pertains to methods of treatment using such systems.
-
公开(公告)号：US20240123095A1
公开(公告)日：2024-04-18
申请号：US18469762
申请日：2023-09-19
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR.
IPC: A61K51/04 , C07D491/18
CPC classification number: A61K51/0446 , C07D491/18
Abstract: In some aspects, the present disclosure pertains to a system for forming a radiopaque product that comprises an iodinated compound comprising one or more diene containing moieties and a multi-arm polymer comprising a plurality of dienophile containing moieties, wherein the diene containing moieties of the iodinated compound couple with the dienophile containing moieties of the multi-arm polymer through a Diels-Alder reaction. Other aspects of the disclosure pertain to crosslinked networks that are formed by combining such an iodinated compound with such a multi-arm polymer, whereupon the diene containing moieties couple with the dienophile containing moieties through a Diels-Alder reaction. Still other aspects of the disclosure pertain to methods of treatment comprising administering to a subject a mixture that comprises such an iodinated compound and such a multi-arm polymer, whereupon the diene containing moieties couple with the dienophile containing moieties by undergoing a Diels-Alder reaction after administration.
-
公开(公告)号：US20230127824A1
公开(公告)日：2023-04-27
申请号：US17972007
申请日：2022-10-24
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, JR. , Kolbein Kolste , Tatyana Dyndikova , Yen-Hao Hsu
Abstract: In some embodiments, the present disclosure pertains to systems for forming a hydrogel that comprise (a) a first composition that comprises a polyiodinated polyamino compound and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to medical hydrogels that are formed by reacting a polyiodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to methods of making polyiodinated polyamino compounds.
-
10.发明申请公开(公告)号：US20250136760A1
公开(公告)日：2025-05-01
申请号：US18934579
申请日：2024-11-01
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Rick Dorn , Cristian Parisi , Yen-Hao Hsu , Joseph Thomas Delaney, Jr. , Sasha Viola Rios , Kyle A. Kalstabakken
IPC: C08G73/02 , A61K9/06 , A61K31/785
Abstract: In some aspects, the present disclosure pertains to amino-acid-based polyamine compounds that are formed by a ring-opening reaction of two or more amino acid N-carboxyanhydride molecules with a polyol having two or more hydroxyl groups under acid catalyzed conditions. In some aspects, the present disclosure pertains to amino-acid-based polyamine compounds that are formed by ester coupling reaction of two or more amine-protected amino acid molecules with a polyol having two or more hydroxyl groups in the presence of an ester coupling agent. In some aspects, the present disclosure pertains to amino-alcohol-based polyamine compounds that are formed by an ester coupling reaction of two or more amine-protected amino alcohol molecules having one or more amino groups and a single hydroxyl group with a polycarboxylic acid compound having two or more carboxyl groups in the presence of an ester coupling agent.
-
-
-
-
-
-
-
-
-
Search Results
32
records
(took 0.019 seconds)
