公开(公告)号：US20080039895A1

公开(公告)日：2008-02-14

申请号：US11697694

申请日：2007-04-06

申请人： Brad Fowler ,  Bradford Gliner ,  David Himes

发明人： Brad Fowler ,  Bradford Gliner ,  David Himes

IPC分类号： A61N1/00

CPC分类号： A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

公开(公告)号：US20070288072A1

公开(公告)日：2007-12-13

申请号：US11697696

申请日：2007-04-06

申请人： Alvaro Pascual-Leone ,  Bradford Gliner ,  David Himes ,  Leif Sloan

发明人： Alvaro Pascual-Leone ,  Bradford Gliner ,  David Himes ,  Leif Sloan

IPC分类号： A61N5/00

CPC分类号： A61N1/36171 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3615

摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.

摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。

公开(公告)号：US08504159B2

公开(公告)日：2013-08-06

申请号：US13104802

申请日：2011-05-10

申请人： Brad Fowler ,  Bradford E. Gliner ,  David Himes

发明人： Brad Fowler ,  Bradford E. Gliner ,  David Himes

IPC分类号： A61B17/52 ,  A61B5/04 ,  A61N2/00 ,  A61N1/00 ,  A61N1/39

CPC分类号： A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

公开(公告)号：US20110213440A1

公开(公告)日：2011-09-01

申请号：US13104802

申请日：2011-05-10

申请人： Brad Fowler ,  Bradford E. Gliner ,  David Himes

发明人： Brad Fowler ,  Bradford E. Gliner ,  David Himes

IPC分类号： A61N1/36

CPC分类号： A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

公开(公告)号：US07949401B2

公开(公告)日：2011-05-24

申请号：US11697694

申请日：2007-04-06

申请人： Brad Fowler ,  Bradford E. Gliner ,  David Himes

发明人： Brad Fowler ,  Bradford E. Gliner ,  David Himes

IPC分类号： A61N1/36

CPC分类号： A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

公开(公告)号：US08926676B2

公开(公告)日：2015-01-06

申请号：US11697696

申请日：2007-04-06

申请人： Alvaro Pascual-Leone ,  Bradford E. Gliner ,  David Himes ,  Leif R. Sloan

发明人： Alvaro Pascual-Leone ,  Bradford E. Gliner ,  David Himes ,  Leif R. Sloan

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3615

摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.

摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。