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    SYSTEMS AND METHODS FOR APPLYING SIGNALS, INCLUDING CONTRALESIONAL SIGNALS, TO NEURAL POPULATIONS
    1.
    发明申请
    SYSTEMS AND METHODS FOR APPLYING SIGNALS, INCLUDING CONTRALESIONAL SIGNALS, TO NEURAL POPULATIONS 有权
    适用信号的系统和方法，包括对比信号，神经人口

    公开(公告)号：US20070288072A1

    公开(公告)日：2007-12-13

    申请号：US11697696

    申请日：2007-04-06

    申请人： Alvaro Pascual-Leone ,  Bradford Gliner ,  David Himes ,  Leif Sloan

    发明人： Alvaro Pascual-Leone ,  Bradford Gliner ,  David Himes ,  Leif Sloan

    IPC分类号： A61N5/00

    CPC分类号： A61N1/36171 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3615

    摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.

    摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。

    Systems and methods for varying electromagnetic and adjunctive neural therapies
    2.
    发明申请
    Systems and methods for varying electromagnetic and adjunctive neural therapies 审中-公开
    用于改变电磁和辅助神经疗法的系统和方法

    公开(公告)号：US20070179558A1

    公开(公告)日：2007-08-02

    申请号：US11344453

    申请日：2006-01-30

    申请人： Bradford Gliner ,  Jeffrey Balzer ,  Brad Fowler ,  Leif Sloan

    发明人： Bradford Gliner ,  Jeffrey Balzer ,  Brad Fowler ,  Leif Sloan

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36082 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/37247

    摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.

    摘要翻译： 公开了用于改变电磁和辅助神经疗法的系统和方法。 根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号 非植入设备）。 该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。 改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。 根据其他实施例的系统可以支持多个信号传递装置。

    METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS
    5.
    发明申请
    METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
    治疗神经病变的方法，包括神经病学和神经病学疾病及相关系统

    公开(公告)号：US20080103548A1

    公开(公告)日：2008-05-01

    申请号：US11833217

    申请日：2007-08-02

    申请人： Brad Fowler ,  Bradford Gliner ,  W. Sheffield ,  Leif Sloan

    发明人： Brad Fowler ,  Bradford Gliner ,  W. Sheffield ,  Leif Sloan

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36082

    摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.

    摘要翻译： 公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。 一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。 该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。 如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者 目标措施。 该方法可以进一步包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

    Methods and systems for establishing parameters for neural stimulation
    6.
    发明申请
    Methods and systems for establishing parameters for neural stimulation 审中-公开
    建立神经刺激参数的方法和系统

    公开(公告)号：US20070088403A1

    公开(公告)日：2007-04-19

    申请号：US11254240

    申请日：2005-10-19

    申请人： Allen Wyler ,  Bradford Gliner ,  Leif Sloan

    发明人： Allen Wyler ,  Bradford Gliner ,  Leif Sloan

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36082 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539

    摘要： Methods and systems for establishing parameters for neural stimulation are disclosed. A method in accordance with one embodiment includes applying a first stimulus to a first neural population associated with a first neural function, using a first set of stimulation parameters. The method can further include detecting a response to the first stimulus at least proximate to the patient's central nervous system and, based at least in part on the response to the first stimulus and on the first set of stimulation parameters, applying a second stimulus to a second neural population. The second neural population can be associated with a second neural function different than the first neural function and can be stimulated using a second set of stimulation parameters. In a further embodiment, evidence of a neural activity can be detected at the patient's central nervous system, and electromagnetic stimulation of a target neural population at the patient's central nervous system can be automatically triggered, based at least in part on the detected evidence.

    摘要翻译： 公开了建立神经刺激参数的方法和系统。 根据一个实施例的方法包括使用第一组刺激参数将第一刺激应用于与第一神经功能相关联的第一神经群体。 该方法还可以包括至少接近患者的中枢神经系统检测对第一刺激的响应，并且至少部分地基于对第一刺激的响应和第一组刺激参数，将第二刺激应用于 第二神经人群。 第二神经群体可以与不同于第一神经功能的第二神经功能相关联，并且可以使用第二组刺激参数来刺激。 在另一实施例中，可以在患者的中枢神经系统处检测到神经活动的证据，并且至少部分地基于检测到的证据，可以自动触发患者中枢神经系统上的目标神经群体的电磁刺激。

    ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS
    7.
    发明申请
    ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS 有权
    由神经元功能丧失，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递

    公开(公告)号：US20080039895A1

    公开(公告)日：2008-02-14

    申请号：US11697694

    申请日：2007-04-06

    申请人： Brad Fowler ,  Bradford Gliner ,  David Himes

    发明人： Brad Fowler ,  Bradford Gliner ,  David Himes

    IPC分类号： A61N1/00

    CPC分类号： A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

    摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

    摘要翻译： 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

    Methods and Systems Employing Intracranial Electrodes for Neurostimulation and/or Electroencephalography
    8.
    发明申请
    Methods and Systems Employing Intracranial Electrodes for Neurostimulation and/or Electroencephalography 审中-公开
    使用颅内电极进行神经刺激和/或脑电图的方法和系统

    公开(公告)号：US20080071323A1

    公开(公告)日：2008-03-20

    申请号：US11944259

    申请日：2007-11-21

    申请人： David Lowry ,  Bradford Gliner ,  Kent Leyde ,  Ben Clopton ,  Jay Miazga ,  Chris Genau

    发明人： David Lowry ,  Bradford Gliner ,  Kent Leyde ,  Ben Clopton ,  Jay Miazga ,  Chris Genau

    IPC分类号： A61N1/04

    CPC分类号： A61N1/0531 ,  A61N1/0534 ,  A61N1/0539

    摘要： Aspects of the invention relate to intracranial electrodes and methods for implanting and using intracranial electrodes. In one particular example, an intracranial electrode includes a shaft having a distal contact surface adapted to electrically contact a surface of a patient's brain, a head associated with the shaft, and threads adapted to fix the electrode with respect to the patient's skull. This electrode may have an adjustable length adapted to change a contact force of the distal contact surface against the surface of the brain by adjusting the length of the electrode.

    摘要翻译： 本发明的方面涉及用于植入和使用颅内电极的颅内电极和方法。 在一个具体实例中，颅内电极包括具有远端接触表面的轴，该远端接触表面适于电接触患者大脑的表面，与该轴相关联的头部以及适于将电极相对于患者头骨固定的螺纹。 该电极可以具有可调节的长度，其适于通过调节电极的长度来改变远端接触表面相对于脑的表面的接触力。

    Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
    9.
    发明申请
    Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures 有权
    用于减少在神经刺激阈值测试程序期间引起侧支神经活动的可能性的系统和方法

    公开(公告)号：US20070043392A1

    公开(公告)日：2007-02-22

    申请号：US11388190

    申请日：2006-03-23

    申请人： Bradford Gliner ,  Kent Leyde

    发明人： Bradford Gliner ,  Kent Leyde

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0534 ,  A61N1/0531 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3787

    摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.

    摘要翻译： 用于确定患者的神经刺激阈值的测试程序。 在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。 该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。 第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。 第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。