公开(公告)号：US07945330B2

公开(公告)日：2011-05-17

申请号：US12244610

申请日：2008-10-02

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/36

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到 治疗电极。

公开(公告)号：US20120022611A1

公开(公告)日：2012-01-26

申请号：US13240053

申请日：2011-09-22

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/36

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

摘要翻译： 以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。 根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑部疾病（例如阿尔茨海默氏症，皮克病，帕金森氏病等）和/或脑部疾病（例如癫痫， 抑郁症等）。 根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。

公开(公告)号：US08065012B2

公开(公告)日：2011-11-22

申请号：US11834650

申请日：2007-08-06

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/05

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： Disclosed are several apparatuses and methods for applying intracranial electrical stimulation to treat or enhance the neural function of the patient. In accordance with the invention, intracranial electrical stimulation can be administered to treat brain damage, brain disease, and/or brain disorders. Additionally the intracranial electrical stimulation can be applied to a normal healthy brain to enhance neural-function or control sensory functions. The electrical stimulation site(s) of the brain are located where neuroplasticity is occurring, expected to occur, or in a region where neuroplasticity is not occurring. The intracranial stimulation is expected to produce a lasting effect on the intended neural activity by applying subthreshold stimulation to the increasing the resting membrane potential of the neurons at the stimulation site.

摘要翻译： 公开了几种用于施加颅内电刺激以治疗或增强患者的神经功能的装置和方法。 根据本发明，可以施用颅内电刺激来治疗脑损伤，脑疾病和/或脑疾病。 此外，颅内电刺激可以应用于正常的健康大脑，以增强神经功能或控制感觉功能。 大脑的电刺激部位位于发生神经可塑性，预期发生或未出现神经可塑性的区域。 预期颅内刺激通过应用亚阈值刺激来增加刺激部位神经元的静息膜电位，对预期的神经活动产生持久的作用。

公开(公告)号：US20100274305A1

公开(公告)日：2010-10-28

申请号：US12771198

申请日：2010-04-30

申请人： Bradford Evan Gliner ,  Alan J. Levy ,  Jeffrey Balzer ,  Andrew D. Firlik ,  W. Doughlas Sheffield

发明人： Bradford Evan Gliner ,  Alan J. Levy ,  Jeffrey Balzer ,  Andrew D. Firlik ,  W. Doughlas Sheffield

IPC分类号： A61N1/00

CPC分类号： A61N1/36103 ,  A61N1/36017 ,  A61N1/3756 ,  C12N13/00

摘要： The following disclosure describes several methods and apparatus for stimulating cells implanted in the regions of nervous system, such as the brain, spinal cord or peripheral nerves. Accordingly, the functionality of the cells can be improved, for example, by differentiating undifferentiated or partially undifferentiated cells into neurons or other cells having action potentials. The method can also include promoting directional growth and connectivity of fully differentiated neural cells implanted in a patient's nervous system through electrical enhancement, for example, electrical stimulation via an anode and cathode. Methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

摘要翻译： 以下公开内容描述了用于刺激植入神经系统诸如脑，脊髓或周围神经的区域中的细胞的几种方法和装置。 因此，可以通过例如将未分化或部分未分化的细胞分化成具有动作电位的神经元或其他细胞来改善细胞的功能。 该方法还可以包括通过电增强（例如经由阳极和阴极的电刺激）促进植入患者神经系统中的完全分化的神经细胞的定向生长和连通性。 根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑疾病（例如，阿尔茨海默氏症，皮克病，帕金森病等）和/或脑部疾病（例如，癫痫，抑郁症 等）。 根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。

公开(公告)号：US07305268B2

公开(公告)日：2007-12-04

申请号：US09978134

申请日：2001-10-15

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/18

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到 治疗电极。

公开(公告)号：US07236831B2

公开(公告)日：2007-06-26

申请号：US10410526

申请日：2003-04-08

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner

IPC分类号： A61N1/00

CPC分类号： A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/375 ,  A61N1/3756

摘要： The present disclosure suggests methods of selecting a stimulation site for stimulating a patient's brain or methods of effectuating a neural-function of a patient associated with an impaired body function. In one exemplary implementation, such a neural function may be effectuated by selecting a stimulation site, positioning at least a first electrode at the stimulation site, and applying an electrical potential to pass a current through the first electrode. If one aspect, this stimulation site may be selected by a) identifying a second body function that is a corollary to the impaired body function, and b) determining a corollary location of the patient's brain that is associated with the second body function and is ipsilateral to the impaired body function.

摘要翻译： 本公开内容提出了选择用于刺激患者的大脑的刺激部位的方法或者与受损的身体功能相关联的患者的神经功能的方法。 在一个示例性实施方案中，可以通过选择刺激部位，在刺激部位定位至少第一电极，以及施加电势以使电流通过第一电极来实现这样的神经功能。 在一个方面，该刺激部位可以通过以下方式来选择：a）识别作为受损身体功能的必然结果的第二身体功能，以及b）确定与第二身体功能相关并且是同侧的患者的大脑的推论位置 对身体功能受损。

公开(公告)号：US20120316630A1

公开(公告)日：2012-12-13

申请号：US13587607

申请日：2012-08-16

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/05

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

公开(公告)号：US07577481B2

公开(公告)日：2009-08-18

申请号：US11355038

申请日：2006-02-15

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/18

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes a method for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

摘要翻译： 以下公开描述了一种用于颅内电刺激治疗或以其他方式实现患者神经功能变化的方法。 几个实施例旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。 这种神经活动的持续变化被定义为“神经可塑性”。 这些方法可用于治疗脑损伤（例如卒中，创伤等），脑部疾病（如阿尔茨海默病，皮克病，帕金森病等）和/或脑部疾病（例如癫痫，抑郁症等） 。 该方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或控制感觉功能（例如疼痛）。

公开(公告)号：US20090093862A1

公开(公告)日：2009-04-09

申请号：US12244610

申请日：2008-10-02

申请人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

发明人： Bradford Evan Gliner ,  Jeffrey Balzer ,  Andrew D. Firlik

IPC分类号： A61N1/00

CPC分类号： A61N1/36021 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/375 ,  A61N1/3756 ,  G06F19/00

摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.

摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或要传送到 治疗电极。

公开(公告)号：US20080161882A1

公开(公告)日：2008-07-03

申请号：US11834660

申请日：2007-08-06

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Katrina S. Firlik

IPC分类号： A61N1/05

CPC分类号： A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.

摘要翻译： 用于治疗患者脑部受损的神经功能的方法和装置。 在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。 该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。 然后通过向刺激部位提供电刺激治疗来治疗患者。 治疗可以包括在治疗期间向电极传送电刺激信号。 在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。