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1.发明授权Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators 有权用于自动优化神经刺激器的刺激参数和电极配置的系统和方法公开(公告)号：US07945330B2
公开(公告)日：2011-05-17
申请号：US12244610
申请日：2008-10-02
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或期望的刺激以被传送到 治疗电极。
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2.发明授权Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures 有权用于减少在神经刺激阈值测试程序期间引起侧支神经活动的可能性的系统和方法公开(公告)号：US08121695B2
公开(公告)日：2012-02-21
申请号：US12619188
申请日：2009-11-16
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/0531 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
摘要翻译： 用于确定患者的神经刺激阈值的测试程序。 在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。 该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。 第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。 第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。
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3.发明授权Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权用于实现患者神经功能持续变化的方法和装置公开(公告)号：US08019425B2
公开(公告)日：2011-09-13
申请号：US12343454
申请日：2008-12-23
IPC分类号： A61N1/00
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译： 用于治疗患者脑部受损的神经功能的方法和装置。 在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。 该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。 然后通过向刺激部位提供电刺激治疗来治疗患者。 治疗可以包括在治疗期间向电极传送电刺激信号。 在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。
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4.发明申请公开(公告)号：US20110208264A1
公开(公告)日：2011-08-25
申请号：US13101306
申请日：2011-05-05
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入患者体内的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或要传送到 治疗电极。
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5.发明申请公开(公告)号：US20100131034A1
公开(公告)日：2010-05-27
申请号：US12619188
申请日：2009-11-16
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61N1/0531 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
摘要翻译： 用于确定患者的神经刺激阈值的测试程序。 在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。 该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。 第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。 第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。
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6.发明申请METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开影响患者神经功能变化的方法和装置公开(公告)号：US20090118788A1
公开(公告)日：2009-05-07
申请号：US12353340
申请日：2009-01-14
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/375 , A61N1/3756
摘要： The present disclosure suggests methods of selecting a stimulation site for stimulating a patient's brain or methods of effectuating a neural-function of a patient associated with an impaired body function. In one exemplary implementation, such a neural function may be effectuated by selecting a stimulation site, positioning at least a first electrode at the stimulation site, and applying an electrical potential to pass a current through the first electrode. If one aspect, this stimulation site may be selected by a) identifying a second body function that is a corollary to the impaired body function, and b) determining a corollary location of the patient's brain that is associated with the second body function and is ipsilateral to the impaired body function.
摘要翻译： 本公开内容提出了选择用于刺激患者的大脑的刺激部位的方法或者与受损的身体功能相关联的患者的神经功能的方法。 在一个示例性实施方案中，可以通过选择刺激部位，在刺激部位定位至少第一电极，以及施加电势以使电流通过第一电极来实现这样的神经功能。 如果一个方面，则可以通过以下方式来选择该刺激部位：a）识别作为受损身体功能的推论的第二身体功能，以及b）确定与第二身体功能相关并且是同侧的患者的大脑的推论位置 对身体功能受损。
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7.发明申请公开(公告)号：US20120316630A1
公开(公告)日：2012-12-13
申请号：US13587607
申请日：2012-08-16
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
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8.发明授权Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权用于实现患者神经功能持续变化的方法和装置公开(公告)号：US07577481B2
公开(公告)日：2009-08-18
申请号：US11355038
申请日：2006-02-15
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes a method for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
摘要翻译： 以下公开描述了一种用于颅内电刺激治疗或以其他方式实现患者神经功能变化的方法。 几个实施例旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。 这种神经活动的持续变化被定义为“神经可塑性”。 这些方法可用于治疗脑损伤（例如卒中，创伤等），脑部疾病（如阿尔茨海默病，皮克病，帕金森病等）和/或脑部疾病（例如癫痫，抑郁症等） 。 该方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或控制感觉功能（例如疼痛）。
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9.发明申请Systems and Methods for Automatically Optimizing Stimulus Parameters and Electrode configurations for neuro-stimulators 有权用于神经刺激器的自动优化激励参数和电极配置的系统和方法公开(公告)号：US20090093862A1
公开(公告)日：2009-04-09
申请号：US12244610
申请日：2008-10-02
IPC分类号： A61N1/00
CPC分类号： A61N1/36021 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , G06F19/00
摘要： Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into a patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively, coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
摘要翻译： 用于自动优化刺激参数和/或电极配置以向患者提供神经刺激的方法和装置。 在一个实施例中，系统包括电极阵列，其具有被配置为植入病人的可植入支撑构件和由支撑构件承载的多个治疗电极。 系统还可以具有可操作地耦合到治疗电极的脉冲系统以将刺激传递到治疗电极，以及被配置为附接到患者的感测位置的感测装置。 感测装置响应于刺激产生响应信号。 该系统还可以包括可操作地耦合到脉冲系统和感测装置的控制器。 控制器包括计算机可操作介质，其产生定义由脉冲系统传递的刺激的命令信号，评估来自感测装置的响应信号，并且确定用于治疗电极的期望配置和/或要传送到 治疗电极。
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10.发明申请METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开影响患者神经功能变化的方法和装置公开(公告)号：US20080161882A1
公开(公告)日：2008-07-03
申请号：US11834660
申请日：2007-08-06
IPC分类号： A61N1/05
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译： 用于治疗患者脑部受损的神经功能的方法和装置。 在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。 该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。 然后通过向刺激部位提供电刺激治疗来治疗患者。 治疗可以包括在治疗期间向电极传送电刺激信号。 在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。
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