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公开(公告)号：US10125116B2
公开(公告)日：2018-11-13
申请号：US14571673
申请日：2014-12-16
申请人： Brandeis University , University of Georgia Research Foundation, Inc. , The Brigham and Women's Hospital, Inc.
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil K. Maurya , Boris Striepen , Suresh K. Gorla , Corey R. Johnson , Mandapati Kavitha , Jihan Khan
IPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052 , C07D249/06
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
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2.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections 审中-公开用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US20150099781A1
公开(公告)日：2015-04-09
申请号：US14571673
申请日：2014-12-16
申请人： Brandeis University , University of Georgia Research Foundation, Inc. , The Brigham and Women's Hospital, Inc.
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil K. Maurya , Boris Striepen , Suresh K. Gorla , Corey R. Johnson , Mandapati Kavitha , Jihan Khan
IPC分类号： C07D401/12 , C07C235/24 , C07D249/06
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本文描述了可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 在某些实施方案中，本发明的化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 此外，本发明提供包含一种或多种本发明化合物的药物组合物。 本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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3.发明授权Compounds and methods for treating mammalian gastrointestinal microbial infections 有权用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US09447134B2
公开(公告)日：2016-09-20
申请号：US14421818
申请日：2013-08-19
IPC分类号： A61K31/535 , C07H15/203 , A61K31/502 , C07D413/14 , C07D213/75 , C07D319/18 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , A61K31/4184 , A61K31/423 , C07C275/30 , C07C275/36 , C07C275/38 , C07C275/40 , C07C275/42 , C07C381/00 , A61K31/17 , A61K31/277 , A61K31/325 , A61K31/4192 , A61K31/427 , A61K31/44 , A61K31/4409 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/7036 , A61K45/06 , C07C271/44 , C07C271/50 , C07C271/52 , C07C275/28 , C07C275/34 , C07D215/38 , C07D237/32 , C07D249/18 , C07D263/57 , C07D295/088 , C07D295/135 , C07D401/04 , C07D401/12
CPC分类号： C07H15/203 , A61K31/17 , A61K31/277 , A61K31/325 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/427 , A61K31/44 , A61K31/4409 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/5375 , A61K31/7036 , A61K45/06 , C07C271/44 , C07C271/50 , C07C271/52 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/40 , C07C275/42 , C07C381/00 , C07C2601/02 , C07C2603/74 , C07D213/75 , C07D215/38 , C07D237/32 , C07D249/18 , C07D263/57 , C07D295/088 , C07D295/135 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , A61K2300/00
摘要： Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively inhibits a parasitic IMPDH versus a host IMPDH. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various parasitic and bacterial infections in mammals are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 公开了可用作IMPDH抑制剂的化合物及其药学上可接受的盐。 在某些实施方案中，化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 还公开了包含一种或多种本发明化合物的药物组合物。 公开了治疗哺乳动物中各种寄生虫和细菌感染的相关方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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4.发明申请COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS 有权化合物和治疗哺乳动物胃肠道微生物感染的方法公开(公告)号：US20150210727A1
公开(公告)日：2015-07-30
申请号：US14421818
申请日：2013-08-19
IPC分类号： C07H15/203 , A61K31/502 , C07D413/12 , C07D401/12 , C07D237/32 , C07D413/04 , A61K31/4439 , C07C275/40 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/28 , C07C275/42 , C07D319/18 , A61K31/277 , C07D295/135 , A61K31/496 , C07D213/75 , A61K31/44 , A61K31/7036 , C07D249/18 , A61K31/4192 , C07D295/088 , A61K31/5375 , C07C271/50 , A61K31/325 , C07C271/44 , C07C271/52 , C07D417/04 , A61K31/427 , C07D413/14 , C07D263/57 , A61K31/423 , C07D215/38 , A61K31/47 , A61K31/4709 , C07D401/04 , A61K31/4409 , A61K45/06 , C07D405/12
CPC分类号： C07H15/203 , A61K31/17 , A61K31/277 , A61K31/325 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/427 , A61K31/44 , A61K31/4409 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/5375 , A61K31/7036 , A61K45/06 , C07C271/44 , C07C271/50 , C07C271/52 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/40 , C07C275/42 , C07C381/00 , C07C2601/02 , C07C2603/74 , C07D213/75 , C07D215/38 , C07D237/32 , C07D249/18 , C07D263/57 , C07D295/088 , C07D295/135 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , A61K2300/00
摘要： Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively inhibits a parasitic IMPDH versus a host IMPDH. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various parasitic and bacterial infections in mammals are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 公开了可用作IMPDH抑制剂的化合物及其药学上可接受的盐。 在某些实施方案中，化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 还公开了包含一种或多种本发明化合物的药物组合物。 公开了治疗哺乳动物中各种寄生虫和细菌感染的相关方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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