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公开(公告)号：US20050054634A1
公开(公告)日：2005-03-10
申请号：US10895431
申请日：2003-12-02
申请人： Brett Busch , Brenton Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason Wu
发明人： Brett Busch , Brenton Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason Wu
IPC分类号： A61K31/435 , A61K31/55 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D487/02
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地，提供了化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US20100173824A1
公开(公告)日：2010-07-08
申请号：US12535453
申请日：2009-08-04
申请人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
发明人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
IPC分类号： A61K31/55 , C07D487/04 , C07D223/14 , C07D491/20 , A61K31/714 , A61K38/28 , A61K31/60 , A61P9/00 , A61P9/10
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地，提供了化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US07595311B2
公开(公告)日：2009-09-29
申请号：US10895431
申请日：2003-12-02
申请人： Brett Busch , Brenton T Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H Wu
发明人： Brett Busch , Brenton T Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H Wu
IPC分类号： A61P3/00 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地，提供了化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08524704B2
公开(公告)日：2013-09-03
申请号：US12535453
申请日：2009-08-04
申请人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
发明人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
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公开(公告)号：US08569352B2
公开(公告)日：2013-10-29
申请号：US11993529
申请日：2006-06-26
申请人： Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
发明人： Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式IIa，IIb，IIc或IId的化合物及其药学上可接受的盐，异构体和前药可用作肝脏X受体活性的调节剂，其中R1，R2，R21，R3和 G在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US20110301128A1
公开(公告)日：2011-12-08
申请号：US13214665
申请日：2011-08-22
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC分类号： A61K31/635 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/433 , A61K31/4025 , A61K31/4725 , A61K31/4709 , A61K31/506 , A61K31/428 , A61K31/40 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P9/00 , A61P21/00 , A61P17/00 , A61P13/12 , A61P25/00 , A61P19/00 , A61P37/02 , A61P3/00 , A61P35/00 , A61P15/08 , A61P5/00 , A61K31/402
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08026237B2
公开(公告)日：2011-09-27
申请号：US11572962
申请日：2005-07-30
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506 , C07D207/34 , C07D403/02 , C07D413/02
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08703805B2
公开(公告)日：2014-04-22
申请号：US11993806
申请日：2006-06-26
申请人： Brett B. Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie Lin Wang , Yinong Xie
发明人： Brett B. Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie Lin Wang , Yinong Xie
IPC分类号： A61K31/4155 , C07D231/12
CPC分类号： C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式Ia，Ib，Ic或Id的化合物及其药学上可接受的盐，异构体和前药，其可用作肝脏X受体活性的调节剂，其中R1，R2，R21，R3 ，和G在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US20100069367A1
公开(公告)日：2010-03-18
申请号：US12517800
申请日：2007-12-07
申请人： Brant Clayton Boren , Brett B. Busch , Xiao-Hui Gu , Vasu Jammalamadaka , Shao Po Lu , Richard Martin , Raju Mohan , Edwin Schweiger , William C. Stevens , Tie-Lin Wang , Yinong Xie , Wei Xu
发明人： Brant Clayton Boren , Brett B. Busch , Xiao-Hui Gu , Vasu Jammalamadaka , Shao Po Lu , Richard Martin , Raju Mohan , Edwin Schweiger , William C. Stevens , Tie-Lin Wang , Yinong Xie , Wei Xu
IPC分类号： A61K31/551 , C07D231/12 , A61K31/415 , C07D233/54 , A61K31/4164 , C07D215/38 , A61K31/47 , C07D413/02 , A61K31/421 , C07D277/08 , A61K31/426 , C07D271/06 , A61K31/4245 , C07D403/02 , A61K31/505 , C07D401/02 , A61K31/4439 , A61K31/5377 , C07D401/14 , A61K31/496 , C07D243/08 , A61P9/00 , A61P25/00 , A61P35/00 , A61P29/00 , A61P3/00 , A61P37/00
CPC分类号： C07D233/90 , C07D231/10
摘要： Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 公开了本发明的化合物，例如式LX-LXIV的化合物及其药学上可接受的盐，异构体或前药，其可用作肝脏X受体（LXR）和法尼斯X受体（FXR）的活性的调节剂， 其中R00，R200，R400，R500，J11，J21，G1，G21和Q在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US08367667B2
公开(公告)日：2013-02-05
申请号：US13214665
申请日：2011-08-22
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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