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1.发明申请CHIMERIC OLIGOMERIC COMPOUNDS COMPRISING ALTERNATING REGIONS OF NORTHERN AND SOUTHERN CONFORMATIONAL GEOMETRY 有权包含北部和南部一致性几何的交替区域的主要低分子化合物公开(公告)号：US20090258931A1
公开(公告)日：2009-10-15
申请号：US12388856
申请日：2009-02-19
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N2310/32 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2320/51
摘要： The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3′-endo conformational geometry (3′-endo regions) or DNA like having southern or C2′-endo/O4′-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
摘要翻译： 本发明涉及具有多个交替区域的新型嵌合寡聚化合物，所述交替区域具有如具有北或3'-端构象几何（3'-末端区域）的RNA或具有南部或C2'端/ O4'端 构象几何。 本发明的寡聚化合物已显示多个体外和体内测定系统中mRNA水平的降低，并且例如用于调查和治疗目的是有用的。
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2.发明授权Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry 有权包括北部和南部构象几何的交替区域的嵌合寡聚化合物公开(公告)号：US08791083B2
公开(公告)日：2014-07-29
申请号：US12388856
申请日：2009-02-19
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N2310/32 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2320/51
摘要： The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3′-endo conformational geometry (3′-endo regions) or DNA like having southern or C2′-endo/O4′-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
摘要翻译： 本发明涉及具有多个交替区域的新型嵌合寡聚化合物，所述交替区域具有如具有北或3'-端构象几何（3'-末端区域）的RNA或具有南部或C2'端/ O4'端 构象几何。 本发明的寡聚化合物已显示多个体外和体内测定系统中mRNA水平的降低，并且例如用于调查和治疗目的是有用的。
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公开(公告)号：US06323029B1
公开(公告)日：2001-11-27
申请号：US09489765
申请日：2000-01-19
IPC分类号： A61K317115
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11026 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glycogen synthase kinase 3 beta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glycogen synthase kinase 3 beta. Methods of using these compounds for modulation of glycogen synthase kinase 3 beta expression and for treatment of diseases associated with expression of glycogen synthase kinase 3 beta are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节糖原合酶激酶3β的表达。 组合物包含靶向编码糖原合酶激酶3β的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节糖原合酶激酶3β表达和治疗与糖原合酶激酶3β表达相关的疾病的方法。
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公开(公告)号：US07563884B2
公开(公告)日：2009-07-21
申请号：US11008747
申请日：2004-12-09
申请人： Lex M. Cowsert , Jacqueline R. Wyatt , Susan M. Freier , Brett P. Monia , Madeline M. Butler , Robert McKay
发明人： Lex M. Cowsert , Jacqueline R. Wyatt , Susan M. Freier , Brett P. Monia , Madeline M. Butler , Robert McKay
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US06316259B1
公开(公告)日：2001-11-13
申请号：US09488856
申请日：2000-01-21
IPC分类号： A61K317088
CPC分类号： C12N15/1137 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y207/01037 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of glycogen synthase kinase 3 alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glycogen synthase kinase 3 alpha. Methods of using these compounds for modulation of glycogen synthase kinase 3 alpha expression and for treatment of diseases associated with expression of glycogen synthase kinase 3 alpha are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节糖原合酶激酶3α的表达。 组合物包含靶向编码糖原合酶激酶3α的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节糖原合酶激酶3α表达和治疗与糖原合酶激酶3α表达有关的疾病的方法。
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公开(公告)号：US08017760B2
公开(公告)日：2011-09-13
申请号：US12046421
申请日：2008-03-11
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madeline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madeline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US06602857B1
公开(公告)日：2003-08-05
申请号：US09629644
申请日：2000-07-31
IPC分类号： A61K3828
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US06306655B1
公开(公告)日：2001-10-23
申请号：US09593589
申请日：2000-06-13
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C/EBP alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C/EBP alpha. Methods of using these compounds for modulation of C/EBP alpha expression and for treatment of diseases associated with expression of C/EBP alpha are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C /EBPα的表达。 组合物包含靶向编码C /EBPα的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C /EBPα表达和治疗与C /EBPα表达相关的疾病的方法。
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公开(公告)号：US06271030B1
公开(公告)日：2001-08-07
申请号：US09593711
申请日：2000-06-14
IPC分类号： C12N500
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C/EBP beta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C/EBP beta. Methods of using these compounds for modulation of C/EBP beta expression and for treatment of diseases associated with expression of C/EBP beta are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C /EBPβ的表达。 组合物包含靶向编码C /EBPβ的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C /EBPβ表达和治疗与C /EBPβ表达相关的疾病的方法。
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10.发明授权Antisense oligonucleotide modulation of tumor necrosis factor-(&agr;) (TNF-&agr;) expression 有权肿瘤坏死因子（α）（TNF-α）表达的反义寡核苷酸调控公开(公告)号：US06228642B1
公开(公告)日：2001-05-08
申请号：US09313932
申请日：1999-05-18
IPC分类号： C07H2104
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-&agr; (TNF-&agr;). Antisense oligonucleotides targeted to nucleic acids encoding TNF-&agr; are preferred. Methods of using these oligonucleotides for inhibition of TNF-&agr; expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-&agr; are provided.
摘要翻译： 提供了抑制人肿瘤坏死因子-α（TNF-α）表达的组合物和方法。 靶向编码TNF-α的核酸的反义寡核苷酸是优选的。 提供了使用这些寡核苷酸抑制TNF-α表达和治疗与TNF-α过度表达相关的疾病，特别是炎性和自身免疫性疾病的方法。
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