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公开(公告)号：US08669365B2
公开(公告)日：2014-03-11
申请号：US12199722
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D211/00 , C07D471/00 , C07D311/96
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US07812164B2
公开(公告)日：2010-10-12
申请号：US11965688
申请日：2007-12-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D401/00 , C07D515/02
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US08785635B2
公开(公告)日：2014-07-22
申请号：US12199689
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D211/00 , C07D401/00 , C07D491/02 , A61K31/196 , A61K45/06 , A61K31/4355 , C07D491/04 , A61K31/198 , A61K31/704 , A61K31/664 , A61K38/21 , A61K31/7076 , C07D491/107 , A61K31/58 , A61K31/17 , A61K31/4745 , A61K31/573 , A61K31/454 , A61K31/56 , C07D491/10 , C07J69/00 , C07D491/048 , A61K31/69 , A61K31/519 , A61K31/7068
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
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公开(公告)号：US20080293754A1
公开(公告)日：2008-11-27
申请号：US11965688
申请日：2007-12-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： A61K31/4355 , C07D211/06 , A61P35/00
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US20090216022A1
公开(公告)日：2009-08-27
申请号：US12199722
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D221/20 , C07D311/96
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
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公开(公告)号：US20090012109A1
公开(公告)日：2009-01-08
申请号：US12199689
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： A61K31/4355 , C07D221/20 , A61P35/00
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US09149465B2
公开(公告)日：2015-10-06
申请号：US12782650
申请日：2010-05-18
申请人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： C07D261/04 , A61K31/5377 , A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/4709 , A61K31/501 , A61K31/506 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/4709 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D261/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
摘要翻译： 本发明提供式（I）的异恶唑啉FAAH抑制剂或其药学上可接受的形式，其中G，Ra，Rb，Rc和Rd各自如本文所定义。 本发明还提供包含式（I）化合物或其药学上可接受的形式的药物组合物和药学上可接受的赋形剂。 本发明还提供了治疗FAAH介导的病症的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物或其药学上可接受的形式。
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公开(公告)号：US08765735B2
公开(公告)日：2014-07-01
申请号：US12782658
申请日：2010-05-18
申请人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A01N43/00 , A61K31/55 , A01N43/42 , A61K31/44 , A01N43/80 , A61K31/42 , C07D261/02 , C07D401/00
CPC分类号： C07D498/10 , A61K31/42 , A61K31/438 , A61K31/55 , C07D261/20 , C07D498/04
摘要： The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
摘要翻译： 本发明提供式（I）的异恶唑啉FAAH抑制剂或其药学上可接受的形式，其中G，Ra，Rb，Rc和Rd各自如本文所定义。 本发明还提供包含式（I）化合物或其药学上可接受的形式的药物组合物和药学上可接受的赋形剂。 本发明还提供了治疗FAAH介导的病症的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物或其药学上可接受的形式。
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公开(公告)号：US20110028478A1
公开(公告)日：2011-02-03
申请号：US12782650
申请日：2010-05-18
申请人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A61K31/5377 , C07D261/04 , A61K31/42 , A61P29/00 , A61P27/06 , A61P9/10 , A61P37/00 , A61P17/00 , A61P25/28 , A61P1/08 , A61P25/30 , A61P9/12 , A61P3/04 , C07D413/12 , A61K31/4439 , A61K31/506 , A61K31/501 , C07D413/10 , A61K31/4245 , A61K31/4709
CPC分类号： A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/4709 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D261/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
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公开(公告)号：US20110034437A1
公开(公告)日：2011-02-10
申请号：US12782658
申请日：2010-05-18
申请人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
发明人： Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号： A61K31/55 , C07D261/20 , A61K31/42 , A61K31/438 , C07D498/10 , A61P25/00 , A61P3/00 , A61P9/00 , A61P1/08 , A61P25/28 , A61P25/30 , A61P25/20 , A61P3/04
CPC分类号： C07D498/10 , A61K31/42 , A61K31/438 , A61K31/55 , C07D261/20 , C07D498/04
摘要： The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
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