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公开(公告)号：US08669365B2
公开(公告)日：2014-03-11
申请号：US12199722
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D211/00 , C07D471/00 , C07D311/96
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US07812164B2
公开(公告)日：2010-10-12
申请号：US11965688
申请日：2007-12-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D401/00 , C07D515/02
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US20090216022A1
公开(公告)日：2009-08-27
申请号：US12199722
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D221/20 , C07D311/96
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
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公开(公告)号：US20090012109A1
公开(公告)日：2009-01-08
申请号：US12199689
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： A61K31/4355 , C07D221/20 , A61P35/00
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US08785635B2
公开(公告)日：2014-07-22
申请号：US12199689
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D211/00 , C07D401/00 , C07D491/02 , A61K31/196 , A61K45/06 , A61K31/4355 , C07D491/04 , A61K31/198 , A61K31/704 , A61K31/664 , A61K38/21 , A61K31/7076 , C07D491/107 , A61K31/58 , A61K31/17 , A61K31/4745 , A61K31/573 , A61K31/454 , A61K31/56 , C07D491/10 , C07J69/00 , C07D491/048 , A61K31/69 , A61K31/519 , A61K31/7068
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
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公开(公告)号：US20080293754A1
公开(公告)日：2008-11-27
申请号：US11965688
申请日：2007-12-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： A61K31/4355 , C07D211/06 , A61P35/00
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US08969363B2
公开(公告)日：2015-03-03
申请号：US13552460
申请日：2012-07-18
申请人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
摘要翻译： 本文描述了调节激酶活性（包括PI3激酶活性）的化合物和药物组合物，以及化合物，药物组合物和治疗与激酶活性（包括PI3激酶活性）相关的疾病和病症的方法。
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公开(公告)号：US08785470B2
公开(公告)日：2014-07-22
申请号：US13552516
申请日：2012-07-18
申请人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D401/14 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C12N9/1205 , C12Y207/01137 , Y02A50/414
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US20130029982A1
公开(公告)日：2013-01-31
申请号：US13552460
申请日：2012-07-18
申请人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： A61K31/519 , C07D513/04 , C07D495/04 , A61K31/4375 , C07D487/04 , A61P37/00 , A61K31/53 , C07D473/34 , A61K31/52 , A61K31/5377 , A61P35/00 , A61P29/00 , C07D471/04 , A61K31/5025
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US07875628B2
公开(公告)日：2011-01-25
申请号：US12171208
申请日：2008-07-10
申请人： Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajannair Janardanannair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
发明人： Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajannair Janardanannair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
IPC分类号： A61K31/4355 , C12N9/99
CPC分类号： C07D491/04
摘要： The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
摘要翻译： 本发明提供用于调节平滑依赖性途径激活的组合物和方法。 本发明提供环巴胺的类似物，其可用于抵消刺猬蛋白途径的不期望的活化的表型效应，例如由刺猬蛋白获得功能，Ptc功能丧失或平滑获得功能突变引起的表型效应。 本发明的化合物特别可用于治疗癌症。
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