公开(公告)号：US20070238174A1

公开(公告)日：2007-10-11

申请号：US11708660

申请日：2007-02-20

申请人： Brian Cousins ,  Michael Garvey ,  John Fink ,  Rachel Williams ,  Patrick Doherty

发明人： Brian Cousins ,  Michael Garvey ,  John Fink ,  Rachel Williams ,  Patrick Doherty

IPC分类号： C12N1/36 ,  C12N5/00 ,  C12N5/02 ,  C12N5/04 ,  C12N5/06

CPC分类号： C12N5/0068 ,  A61L27/50 ,  A61L2400/12 ,  A61L2400/18 ,  C12N2533/12 ,  C12N2533/14 ,  C12N2533/30

摘要： The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least a part of the substrate, topographical features having at least one nano scale dimension. These topographical features are adapted to inhibit cell or tissue growth thereon and/or therebetween.

摘要翻译： 本发明涉及新颖的底物，制造方法和用途。 本发明的基底包括基部和覆盖基部的至少一部分的表面层，其间设置有粘结层。 表面层在至少一部分基底上提供具有至少一个纳米级尺寸的形貌特征。 这些形貌特征适于抑制其上和/或其间的细胞或组织生长。