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    Microcoil vaso-occlusive device with multi-axis secondary configuration
    2.
    发明授权
    Microcoil vaso-occlusive device with multi-axis secondary configuration 有权

    公开(公告)号：US07033374B2

    公开(公告)日：2006-04-25

    申请号：US10043947

    申请日：2002-01-11

    申请人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    发明人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00526 ,  A61B2017/00867

    摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

    Microcoil vaso-occlusive device with multi-axis secondary configuration
    6.
    发明授权
    Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
    具有多轴二次配置的微线圈血管闭塞装置

    公开(公告)号：US07029486B2

    公开(公告)日：2006-04-18

    申请号：US10247231

    申请日：2002-09-19

    申请人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    发明人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00867

    摘要： A microcoil vaso-occlusive device has a minimum energy state secondary configuration having a plurality of curved segments, each defining a discrete axis. The secondary configuration may be a plurality of interconnected closed loops; an array of laterally-alternating open loops; a series of tangential closed loops; or a logarithmic spiral. The device, in its secondary cofiguration, has a dimension that is substantially larger than the largest dimension of the vascular site in which it is to be deployed. Thus, confinement of the device within the site causes it to assume a configuration with a higher energy state than the minimum energy state. Because the secondary configuration is larger (in at least one dimension) than the site, the device is constrained, by contact with the walls of the site, from returning to its secondary configuration, and shifting of the device due to blood flow is minimized.

    摘要翻译： 微线圈血管闭塞装置具有最小能量状态次级构型，其具有多个弯曲段，每个限定离散轴。 二次配置可以是多个互连的闭环; 横向交替的开环阵列; 一系列切向闭环; 或对数螺旋。 该装置在其二次配置中具有的尺寸基本上大于其将被部署的血管部位的最大尺寸。 因此，在站点内的设备的限制使其呈现具有比最小能量状态更高的能量状态的配置。 由于二次配置比现场更大（至少一个维度），所以通过与现场的墙壁接触来限制设备从返回到其次要配置，并且由于血液流动而使设备的移动被最小化。

    Microcoil vaso-occlusive device with multi-axis secondary configuration
    7.
    发明授权
    Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
    具有多轴二次配置的微线圈血管闭塞装置

    公开(公告)号：US08323306B2

    公开(公告)日：2012-12-04

    申请号：US11398081

    申请日：2006-04-05

    申请人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    发明人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

    IPC分类号： A61M29/00 ,  A61F2/06

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00867

    摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. Confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow.

    摘要翻译： 血管闭塞装置包括形成为最小能量状态次级构造的微线圈，其包括多个弯曲段，每个弯曲段限定离散轴线，由此该装置在其最小能量状态构造中限定多个轴线。 动脉瘤内装置的限制使其呈现具有比最小能量状态更高的能量状态的三维构型。 由于装置的最小能量状态构造比动脉瘤更大（至少一个维度），因此部署的装置受到与动脉瘤壁的接触的约束，从而返回到其最小能量状态。 该装置与动脉瘤壁的接合最小化由于血流引起的移动或翻滚。

    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
    10.
    发明授权
    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
    止血导管和治疗中风和其他小血管血栓栓塞障碍的方法

    公开(公告)号：US07691121B2

    公开(公告)日：2010-04-06

    申请号：US10730860

    申请日：2003-12-09

    申请人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    发明人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    IPC分类号： A61M29/00

    CPC分类号： A61B17/22032 ,  A61B17/135 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61M2025/0042 ,  A61M2025/0183

    摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may included a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

    摘要翻译： 用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。 本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。 在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。 此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。 凝块移除装置可以包括设计成防止血块从其中通过的可展开的线窝。 输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。 外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。 输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。