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1.发明申请公开(公告)号：US20160193324A1
公开(公告)日：2016-07-07
申请号：US14916458
申请日：2014-09-02
申请人： Brian K. MEYER , Robert K. EVANS , Channing R. BEALS , David C. KASLOW , Merck Sharp & Dohme Corp.
IPC分类号： A61K39/25 , A61K39/145 , A61K39/165 , A61K39/102 , A61K39/05 , A61K39/08 , A61K39/02 , A61K39/13 , C12N7/00 , A61K39/20
CPC分类号： A61K39/25 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/102 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/165 , A61K39/20 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , C12N7/00 , C12N2710/16734 , C12N2760/16034 , C12N2760/18434 , C12N2770/32634 , C12N2770/36234
摘要： The present invention relates to a method of vaccinating a patient against varicella zoster virus (VZV) by delivery of an effective amount of a live attenuated VZV vaccine to the epidermis or the dermis of a patient's skin at a depth of between about 100 and about 700 microns from the surface of the skin, which is useful for preventing herpes zoster or reducing the severity or duration thereof. In embodiments of the invention, the patient is 50 years of age or older and has been previously exposed to VZV. The invention also relates to a method of preventing VZV infection in an individual who was not previously infected with VZV comprising administering an effective amount of a live attenuated VZV vaccine to the epidermis or the dermis of the individual's skin at a depth of between about 100 and about 700 microns from the surface of the skin.
摘要翻译： 本发明涉及一种通过将有效量的活减毒VZV疫苗递送至患者皮肤的表皮或真皮的约100至约700埃的深度来接种患者抗水痘带状疱疹病毒（VZV）的方法 从皮肤表面微米，其可用于预防带状疱疹或降低其严重性或持续时间。 在本发明的实施方案中，患者为50岁或以上，并且先前已经暴露于VZV。 本发明还涉及一种在先前未感染VZV的个体中预防VZV感染的方法，其包括以约100至约100的浓度施用有效量的活减毒VZV疫苗至个体皮肤的表皮或真皮， 距离皮肤表面约700微米。
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公开(公告)号：US10350289B2
公开(公告)日：2019-07-16
申请号：US14916458
申请日：2014-09-02
IPC分类号： A61K39/165 , C12N7/00 , A61K39/25 , A61K39/12 , A61K39/05 , A61K39/08 , A61K39/02 , A61K39/102 , A61K39/13 , A61K39/145 , A61K39/20 , A61K39/00
摘要： The present invention relates to a method of vaccinating a patient against varicella zoster virus (VZV) by delivery of an effective amount of a live attenuated VZV vaccine to the epidermis or the dermis of a patient's skin at a depth of between about 100 and about 700 microns from the surface of the skin, which is useful for preventing herpes zoster or reducing the severity or duration thereof. In embodiments of the invention, the patient is 50 years of age or older and has been previously exposed to VZV. The invention also relates to a method of preventing VZV infection in an individual who was not previously infected with VZV comprising administering an effective amount of a live attenuated VZV vaccine to the epidermis or the dermis of the individual's skin at a depth of between about 100 and about 700 microns from the surface of the skin.
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公开(公告)号：US08541426B2
公开(公告)日：2013-09-24
申请号：US12668604
申请日：2008-07-04
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K9/0048
摘要： Inhibitors of Janus kinase-3 (“Jak3”) are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. Jak3 inhibitors useful for treating eye disorders include the compound 3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile.
摘要翻译： Janus激酶-3（“Jak3”）的抑制剂可用于治疗干眼病和其它需要润湿眼睛的疾病。 用于治疗眼睛疾病的Jak3抑制剂包括化合物3 - {（3R，4R）-4-甲基-3- [甲基 - （7H-吡咯并[2,3-d]嘧啶-4-基） - 氨基] - 哌啶 -1-基} -3-氧代 - 丙腈。
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公开(公告)号：US20100267751A1
公开(公告)日：2010-10-21
申请号：US12668604
申请日：2008-07-04
IPC分类号： A61K31/519 , A61P27/02
CPC分类号： A61K31/519 , A61K9/0048
摘要： Inhibitors of Janus kinase-3 (“Jak3”) are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. Jak3 inhibitors useful for treating eye disorders include the compound 3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo [2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile.
摘要翻译： Janus激酶-3（“Jak3”）的抑制剂可用于治疗干眼病和其它需要润湿眼睛的疾病。 用于治疗眼睛疾病的Jak3抑制剂包括化合物3 - {（3R，4R）-4-甲基-3- [甲基 - （7H-吡咯并[2,3-d]嘧啶-4-基） - 氨基] - 哌啶 -1-基} -3-氧代 - 丙腈。
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